EP0648128A4 - ADN CODANT L'ENZYME DE CONVERSION DU PRECURSEUR DE L'INTERLEUKINE 1-g(b). - Google Patents

ADN CODANT L'ENZYME DE CONVERSION DU PRECURSEUR DE L'INTERLEUKINE 1-g(b).

Info

Publication number
EP0648128A4
EP0648128A4 EP93916529A EP93916529A EP0648128A4 EP 0648128 A4 EP0648128 A4 EP 0648128A4 EP 93916529 A EP93916529 A EP 93916529A EP 93916529 A EP93916529 A EP 93916529A EP 0648128 A4 EP0648128 A4 EP 0648128A4
Authority
EP
European Patent Office
Prior art keywords
dna encoding
converting enzyme
encoding precursor
precursor interleukin
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93916529A
Other languages
German (de)
English (en)
Other versions
EP0648128A1 (fr
Inventor
Andrew D Howard
Susan M Molineaux
Michael J Tocci
Jimmy R Calaycay
Douglas K Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0648128A1 publication Critical patent/EP0648128A1/fr
Publication of EP0648128A4 publication Critical patent/EP0648128A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP93916529A 1992-06-24 1993-06-14 ADN CODANT L'ENZYME DE CONVERSION DU PRECURSEUR DE L'INTERLEUKINE 1-g(b). Withdrawn EP0648128A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90639292A 1992-06-24 1992-06-24
PCT/US1993/005687 WO1994000154A1 (fr) 1992-06-24 1993-06-14 ADN CODANT L'ENZYME DE CONVERSION DU PRECURSEUR DE L'INTERLEUKINE 1$g(b)
US906392 2001-07-16

Publications (2)

Publication Number Publication Date
EP0648128A1 EP0648128A1 (fr) 1995-04-19
EP0648128A4 true EP0648128A4 (fr) 1995-07-26

Family

ID=25422367

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93916529A Withdrawn EP0648128A4 (fr) 1992-06-24 1993-06-14 ADN CODANT L'ENZYME DE CONVERSION DU PRECURSEUR DE L'INTERLEUKINE 1-g(b).

Country Status (5)

Country Link
EP (1) EP0648128A4 (fr)
JP (1) JPH08500242A (fr)
AU (1) AU4634993A (fr)
CA (1) CA2136981A1 (fr)
WO (1) WO1994000154A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
AU733479B2 (en) * 1994-06-17 2001-05-17 Vertex Pharmaceuticals Incorporated Crystal structure and mutants of interleukin-1beta converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5756466A (en) 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5856116A (en) * 1994-06-17 1999-01-05 Vertex Pharmaceuticals, Incorporated Crystal structure and mutants of interleukin-1 beta converting enzyme
CA2202549C (fr) * 1994-10-14 2003-08-05 Tara Seshadri Animal transgenique comprenant un gene de l'enzyme de conversion d'interleukine-1.beta. a fonction perturbee
WO1996026280A1 (fr) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOUVELLE CYSTEINE PROTEASE APPARENTEE A L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
US5869315A (en) 1995-12-18 1999-02-09 Basf Aktiengesellschaft Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en) 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1
US6180402B1 (en) * 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
GB2324529A (en) * 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
ATE296812T1 (de) 1998-03-09 2005-06-15 Vertex Pharma 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
NZ528282A (en) 1998-03-19 2005-05-27 Vertex Pharma Interleukin-1 beta converting enzyme inhibitors
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2383392A1 (fr) * 2001-04-27 2002-10-27 Matsushita Electric Industrial Co., Ltd. Biodispositif et appareil de mesure quantitative et methode connexe
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
EP1778221A2 (fr) 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Traitement de maladies autoinflammatopires a l'aide d'inhibiteurs de l'ice
IL278384B2 (en) * 2018-05-22 2024-02-01 Immunitybio Inc Optimization of NK-92 cell growth using poloxamer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533350A1 (fr) * 1991-08-16 1993-03-24 Merck & Co. Inc. ADN codant l'enzyme de conversion du précurseur de l'interleukine 1B

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533350A1 (fr) * 1991-08-16 1993-03-24 Merck & Co. Inc. ADN codant l'enzyme de conversion du précurseur de l'interleukine 1B

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D CERRETTI ET AL: "Molecular cloning of the interleukin 1beta converting enzyme", SCIENCE, vol. 256, 3 April 1992 (1992-04-03), pages 97 - 100, XP002930919, DOI: doi:10.1126/science.1373520 *
N. THORNBERRY: "A novel heterodimeric cysteine protease is requiered for interleukin-1beta processing in monocytes", NATURE, vol. 356, 30 April 1992 (1992-04-30), LONDON GB, pages 768 - 774 *
See also references of WO9400154A1 *

Also Published As

Publication number Publication date
WO1994000154A1 (fr) 1994-01-06
EP0648128A1 (fr) 1995-04-19
AU4634993A (en) 1994-01-24
CA2136981A1 (fr) 1994-01-06
JPH08500242A (ja) 1996-01-16

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Legal Events

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