CA2132750A1 - Oligosaccharides presentant une grand affinite de liaison avec des facteurs de croissance - Google Patents

Oligosaccharides presentant une grand affinite de liaison avec des facteurs de croissance

Info

Publication number
CA2132750A1
CA2132750A1 CA 2132750 CA2132750A CA2132750A1 CA 2132750 A1 CA2132750 A1 CA 2132750A1 CA 2132750 CA2132750 CA 2132750 CA 2132750 A CA2132750 A CA 2132750A CA 2132750 A1 CA2132750 A1 CA 2132750A1
Authority
CA
Canada
Prior art keywords
oligosaccharide
fgf
sulphated
idoa
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2132750
Other languages
English (en)
Inventor
Jeremy E. Turnbull
John T. Gallagher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2132750A1 publication Critical patent/CA2132750A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
CA 2132750 1992-03-23 1993-03-23 Oligosaccharides presentant une grand affinite de liaison avec des facteurs de croissance Abandoned CA2132750A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9206291.8 1992-03-23
GB929206291A GB9206291D0 (en) 1992-03-23 1992-03-23 Oligosaccharides having growth factor binding affinity

Publications (1)

Publication Number Publication Date
CA2132750A1 true CA2132750A1 (fr) 1993-09-30

Family

ID=10712652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2132750 Abandoned CA2132750A1 (fr) 1992-03-23 1993-03-23 Oligosaccharides presentant une grand affinite de liaison avec des facteurs de croissance

Country Status (6)

Country Link
EP (1) EP0632818A1 (fr)
JP (1) JPH07505179A (fr)
AU (1) AU3763293A (fr)
CA (1) CA2132750A1 (fr)
GB (2) GB9206291D0 (fr)
WO (1) WO1993019096A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
JPH09512822A (ja) * 1994-05-06 1997-12-22 グリコメド・インコーポレイテッド Ｏ−脱硫酸化ヘパリン誘導体とその製造法および使用
DE69535565T2 (de) * 1994-07-01 2008-05-08 Seikagaku Corp. Verwendung von desulfatiertem Heparin
US6399386B1 (en) 1994-07-22 2002-06-04 President And Fellows Of Harvard College Method of isolating receptor and ligand DNA
US5766923A (en) * 1994-07-22 1998-06-16 President & Fellows Of Harvard College Isolated nucleic acid encoding ligands for FGFR
WO1996023003A1 (fr) * 1995-01-27 1996-08-01 Amrad Operations Pty. Ltd. Molecule therapeutique
US5733893A (en) * 1995-03-15 1998-03-31 Washington University Method of identifying molecules that regulate FGF activity
GB9507366D0 (en) * 1995-04-08 1995-05-31 Zeneca Ltd Assay
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
EP0935965A4 (fr) * 1996-04-23 2002-01-23 Toray Industries Agent anti-pylori
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US6861254B1 (en) 1997-10-24 2005-03-01 Massachusetts Institute Of Technology Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor
GB9722604D0 (en) * 1997-10-28 1997-12-24 Cancer Res Campaign Tech Heparin-binding growth factor derivatives
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
CA2643162C (fr) 1999-04-23 2018-01-02 Massachusetts Institute Of Technology Systeme et procede d'identification et de sequencage de polymeres, et d'analyse de leur composition par comparaison des proprietes
WO2001066772A2 (fr) 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii et ses utilisations
WO2002023190A2 (fr) 2000-09-12 2002-03-21 Massachusetts Institute Of Technology Procedes et produits apparentes a l'heparine de faible poids moleculaire
JP2004523479A (ja) 2000-10-18 2004-08-05 マサチューセッツ　インスティテュート　オブ　テクノロジー 多糖の肺送達に関する方法および産物
CH696701A5 (de) 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
DE10258770B4 (de) * 2001-12-18 2005-02-10 F. Hoffmann-La Roche Ag Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen
WO2005079817A1 (fr) * 2004-02-18 2005-09-01 The Texas A & M University System Heparine/heparane sulfate purifie a affinite destine a la regulation de l'activite biologique du recepteur fgf
EP2612919A1 (fr) * 2010-09-02 2013-07-10 Sumitomo Bakelite Company Limited Polysaccharide sulfaté capable de liaison au facteur de croissance et utilisation dudit polysaccharide
WO2014185858A1 (fr) 2013-05-16 2014-11-20 Agency For Science, Technology And Research Sulfates d'héparane
JP6709217B2 (ja) 2014-11-19 2020-06-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 皮膚の修復および／または再生において使用するためのヘパラン硫酸
WO2016080915A1 (fr) 2014-11-19 2016-05-26 Agency For Science, Technology And Research Utilisation cosmétique de sulfate d'héparane
WO2016111651A1 (fr) * 2015-01-09 2016-07-14 Agency For Science, Technology And Research Pdgf-b/pdgf-bb se liant à des variants de sulphates d'héparane
EP3724238A4 (fr) 2017-12-11 2021-12-22 Agency for Science, Technology and Research Oligosaccharides d'héparine et de sulfate d'héparane

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
CA1136620A (fr) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Fragments d'heparine ayant une activite anticoagulante selective
FR2538404B1 (fr) * 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2597484B1 (fr) * 1986-04-17 1988-12-23 Sanofi Sa Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques.
PT93847A (pt) * 1989-04-24 1990-11-20 Harvard College Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem
NO921495L (no) * 1991-04-16 1992-10-19 Seikagaku Kogyo Co Ltd Oligosakkarid og fremgangsmaate for dets fremstilling

Also Published As

Publication number Publication date
EP0632818A1 (fr) 1995-01-11
GB9305979D0 (en) 1993-05-12
WO1993019096A1 (fr) 1993-09-30
GB2265905B (en) 1995-01-25
GB9206291D0 (en) 1992-05-06
GB2265905A (en) 1993-10-13
AU3763293A (en) 1993-10-21
JPH07505179A (ja) 1995-06-08

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CA2132750A1 (fr) Oligosaccharides presentant une grand affinite de liaison avec des facteurs de croissance
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Legal Events

Date Code Title Description
FZDE Dead