GB2265905B - Oligosaccharides having growth factor binding affinity - Google Patents

Oligosaccharides having growth factor binding affinity

Info

Publication number
GB2265905B
GB2265905B GB9305979A GB9305979A GB2265905B GB 2265905 B GB2265905 B GB 2265905B GB 9305979 A GB9305979 A GB 9305979A GB 9305979 A GB9305979 A GB 9305979A GB 2265905 B GB2265905 B GB 2265905B
Authority
GB
United Kingdom
Prior art keywords
oligosaccharides
growth factor
binding affinity
factor binding
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9305979A
Other versions
GB9305979D0 (en
GB2265905A (en
Inventor
John Thomas Gallagher
Jeremy Ewan Turnbull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Cancer Research Campaign Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd filed Critical Cancer Research Campaign Technology Ltd
Publication of GB9305979D0 publication Critical patent/GB9305979D0/en
Publication of GB2265905A publication Critical patent/GB2265905A/en
Application granted granted Critical
Publication of GB2265905B publication Critical patent/GB2265905B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
GB9305979A 1992-03-23 1993-03-23 Oligosaccharides having growth factor binding affinity Expired - Fee Related GB2265905B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929206291A GB9206291D0 (en) 1992-03-23 1992-03-23 Oligosaccharides having growth factor binding affinity

Publications (3)

Publication Number Publication Date
GB9305979D0 GB9305979D0 (en) 1993-05-12
GB2265905A GB2265905A (en) 1993-10-13
GB2265905B true GB2265905B (en) 1995-01-25

Family

ID=10712652

Family Applications (2)

Application Number Title Priority Date Filing Date
GB929206291A Pending GB9206291D0 (en) 1992-03-23 1992-03-23 Oligosaccharides having growth factor binding affinity
GB9305979A Expired - Fee Related GB2265905B (en) 1992-03-23 1993-03-23 Oligosaccharides having growth factor binding affinity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB929206291A Pending GB9206291D0 (en) 1992-03-23 1992-03-23 Oligosaccharides having growth factor binding affinity

Country Status (6)

Country Link
EP (1) EP0632818A1 (en)
JP (1) JPH07505179A (en)
AU (1) AU3763293A (en)
CA (1) CA2132750A1 (en)
GB (2) GB9206291D0 (en)
WO (1) WO1993019096A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
JPH09512822A (en) * 1994-05-06 1997-12-22 グリコメド・インコーポレイテッド O-desulfated heparin derivatives, their production and use
DE69531945T2 (en) 1994-07-01 2004-08-19 Seikagaku Corp. METHOD FOR PRODUCING DESULFATED POLYSACCHARIDE AND DESULFATED HEPARINE
US5766923A (en) * 1994-07-22 1998-06-16 President & Fellows Of Harvard College Isolated nucleic acid encoding ligands for FGFR
US6399386B1 (en) 1994-07-22 2002-06-04 President And Fellows Of Harvard College Method of isolating receptor and ligand DNA
WO1996023003A1 (en) * 1995-01-27 1996-08-01 Amrad Operations Pty. Ltd. A therapeutic molecule
US5733893A (en) * 1995-03-15 1998-03-31 Washington University Method of identifying molecules that regulate FGF activity
GB9507366D0 (en) * 1995-04-08 1995-05-31 Zeneca Ltd Assay
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
EP0935965A4 (en) * 1996-04-23 2002-01-23 Toray Industries Antipylori agent
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US6861254B1 (en) 1997-10-24 2005-03-01 Massachusetts Institute Of Technology Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor
GB9722604D0 (en) * 1997-10-28 1997-12-24 Cancer Res Campaign Tech Heparin-binding growth factor derivatives
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
EP1190364A2 (en) 1999-04-23 2002-03-27 Massachusetts Institute Of Technology System and method for polymer notation
JP2003525946A (en) * 2000-03-08 2003-09-02 マサチューセッツ インスティテュート オブ テクノロジー Heparinase III and uses thereof
ES2324701T3 (en) 2000-09-12 2009-08-13 Massachusetts Institute Of Technology METHODS AND PRODUCTS RELATED TO MOLECULAR WEIGHT HEPARINE.
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
DE10258770B4 (en) * 2001-12-18 2005-02-10 F. Hoffmann-La Roche Ag Test for inhibitors of heparanase, useful for treatment of e.g. cancer and inflammatory disease, using immobilized, labeled heparanase substrate
CH696701A5 (en) 2001-12-18 2007-10-15 Hoffmann La Roche A method for testing an agent for its ability to inhibit heparanase activity.
WO2005079817A1 (en) * 2004-02-18 2005-09-01 The Texas A & M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the fgf receptor
JPWO2012029863A1 (en) * 2010-09-02 2013-10-31 住友ベークライト株式会社 Sulfated polysaccharides binding to growth factors and their use
SG11201509430WA (en) 2013-05-16 2015-12-30 Agency Science Tech & Res Heparan sulphates
SG11201704086WA (en) 2014-11-19 2017-06-29 Agency Science Tech & Res Cosmetic use of heparan sulphate
JP6709217B2 (en) 2014-11-19 2020-06-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Heparan sulfate for use in skin repair and/or regeneration
US10723813B2 (en) 2015-01-09 2020-07-28 Agency For Science, Technology And Research PDGF-B /PDGF-BB binding variants of heparan sulfates
CN111741980B (en) 2017-12-11 2023-02-17 新加坡科技研究局 Heparin and heparan sulfate oligosaccharides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2035349A (en) * 1978-11-06 1980-06-18 Choay Sa Mucopolysaccharide composition having a regulatory action on coagulation medicament containtaining it and process for preparing it
EP0014184A2 (en) * 1979-01-08 1980-08-06 Kabi AB Heparin fragments having a selective anticoagulation activity and process for their preparation
EP0116801A1 (en) * 1982-12-28 1984-08-29 SCLAVO S.p.A. Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them
EP0244298A2 (en) * 1986-04-17 1987-11-04 Sanofi Oligosaccharides of heparin having an affinity for cell growth factors
US4933326A (en) * 1983-03-08 1990-06-12 Opocrin S.P.A. Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
EP0509517A2 (en) * 1991-04-16 1992-10-21 Seikagaku Kogyo Kabushiki Kaisha Oligosaccharide having affinity for fibroblast growth factor and process for producing same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT93847A (en) * 1989-04-24 1990-11-20 Harvard College PROCESS FOR THE PREPARATION OF OLIGOSACARIDES OF LOW MOLECULAR WEIGHT DERIVED FROM HEPARIN OR DESPOLYMENED HEPARAN SULFATE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2035349A (en) * 1978-11-06 1980-06-18 Choay Sa Mucopolysaccharide composition having a regulatory action on coagulation medicament containtaining it and process for preparing it
EP0014184A2 (en) * 1979-01-08 1980-08-06 Kabi AB Heparin fragments having a selective anticoagulation activity and process for their preparation
EP0116801A1 (en) * 1982-12-28 1984-08-29 SCLAVO S.p.A. Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions containing them
US4933326A (en) * 1983-03-08 1990-06-12 Opocrin S.P.A. Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
EP0244298A2 (en) * 1986-04-17 1987-11-04 Sanofi Oligosaccharides of heparin having an affinity for cell growth factors
EP0509517A2 (en) * 1991-04-16 1992-10-21 Seikagaku Kogyo Kabushiki Kaisha Oligosaccharide having affinity for fibroblast growth factor and process for producing same

Also Published As

Publication number Publication date
GB9305979D0 (en) 1993-05-12
CA2132750A1 (en) 1993-09-30
GB9206291D0 (en) 1992-05-06
JPH07505179A (en) 1995-06-08
GB2265905A (en) 1993-10-13
WO1993019096A1 (en) 1993-09-30
AU3763293A (en) 1993-10-21
EP0632818A1 (en) 1995-01-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19970323