CA2126678A1 - Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs - Google Patents

Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs

Info

Publication number
CA2126678A1
CA2126678A1 CA002126678A CA2126678A CA2126678A1 CA 2126678 A1 CA2126678 A1 CA 2126678A1 CA 002126678 A CA002126678 A CA 002126678A CA 2126678 A CA2126678 A CA 2126678A CA 2126678 A1 CA2126678 A1 CA 2126678A1
Authority
CA
Canada
Prior art keywords
spiperone
alkyl
bromide
group
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002126678A
Other languages
English (en)
Inventor
Richard J. Sharpe
Kenneth A. Arndt
Stephen J. Galli
Peter C. Meltzer
Raj K. Razdan
Howard P. Sard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/815,283 external-priority patent/US5290783A/en
Priority claimed from US07/831,429 external-priority patent/US5244902A/en
Priority claimed from US07/893,536 external-priority patent/US5703088A/en
Priority claimed from US07/893,534 external-priority patent/US5574041A/en
Application filed by Individual filed Critical Individual
Publication of CA2126678A1 publication Critical patent/CA2126678A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002126678A 1991-12-27 1992-12-23 Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs Abandoned CA2126678A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US07/815,283 US5290783A (en) 1990-03-16 1991-12-27 Use of spiperone derivatives as immunosuppressant agents
US07/831,429 US5244902A (en) 1989-08-21 1992-02-05 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US07/893,536 US5703088A (en) 1989-08-21 1992-06-04 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US07/893,536 1992-06-04
US07/815,283 1992-06-04
US07/893,534 1992-06-04
US07/831,429 1992-06-04
US07/893,534 US5574041A (en) 1990-03-16 1992-06-04 Use of spiperone derivatives as immunosuppressant agents

Publications (1)

Publication Number Publication Date
CA2126678A1 true CA2126678A1 (fr) 1993-07-08

Family

ID=27505847

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002126678A Abandoned CA2126678A1 (fr) 1991-12-27 1992-12-23 Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs

Country Status (5)

Country Link
EP (1) EP0661972A1 (fr)
JP (1) JPH08500326A (fr)
AU (1) AU3421493A (fr)
CA (1) CA2126678A1 (fr)
WO (1) WO1993012789A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
JP2000502346A (ja) * 1995-12-21 2000-02-29 イーライ・リリー・アンド・カンパニー 皮膚炎の処置方法
AU3809999A (en) * 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
JP2006510586A (ja) * 2002-08-29 2006-03-30 ユニバーシティー オブ サザンプトン 肝疾患治療のための薬剤の調製におけるアポトーシス誘導物質の使用方法
PL377047A1 (pl) 2002-09-09 2006-01-23 Janssen Pharmaceutica, N.V. Hydroksyalkilopodstawione pochodne 1,3,8-triazaspiro [4,5]-dekan-4-onu przydatne w leczeniu zaburzeń, w których pośredniczy receptor ORL-1
CN103202840B (zh) 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101679430B (zh) 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
CN110785169A (zh) * 2017-05-12 2020-02-11 千年制药公司 用三氮杂螺[4.5]癸酮治疗胃轻瘫

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
WO1991002527A1 (fr) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Procede et composition de traitement d'hypersensibilite cutanee, oculaire et des muqueuses, d'etats inflammatoires et hyperproliferatifs en utilisant des preparations topiques d'antagonistes de serotonine
EP0520032B1 (fr) * 1990-03-16 1998-09-16 Beth Israel Hospital Association Utilisation de spiperone comme agent immunosuppresseur et anti-inflammatoire

Also Published As

Publication number Publication date
EP0661972A4 (fr) 1994-10-27
EP0661972A1 (fr) 1995-07-12
AU3421493A (en) 1993-07-28
WO1993012789A1 (fr) 1993-07-08
JPH08500326A (ja) 1996-01-16

Similar Documents

Publication Publication Date Title
US5693645A (en) Use of spiperone or spiperone derivatives as immunosuppressant agents
US5290783A (en) Use of spiperone derivatives as immunosuppressant agents
US5703088A (en) Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5631017A (en) Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5244902A (en) Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
CA2126678A1 (fr) Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs
US5637314A (en) Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US20010006972A1 (en) Nk-1 receptor antagonists for the treatment of symptoms of irritable bowel syndrome
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US5484788A (en) Buspirone as a systemic immunosuppressant
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US5574041A (en) Use of spiperone derivatives as immunosuppressant agents
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Legal Events

Date Code Title Description
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