CA2126678A1 - Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs - Google Patents

Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs

Info

Publication number
CA2126678A1
CA2126678A1 CA002126678A CA2126678A CA2126678A1 CA 2126678 A1 CA2126678 A1 CA 2126678A1 CA 002126678 A CA002126678 A CA 002126678A CA 2126678 A CA2126678 A CA 2126678A CA 2126678 A1 CA2126678 A1 CA 2126678A1
Authority
CA
Canada
Prior art keywords
spiperone
alkyl
bromide
group
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002126678A
Other languages
English (en)
Inventor
Richard J. Sharpe
Kenneth A. Arndt
Stephen J. Galli
Peter C. Meltzer
Raj K. Razdan
Howard P. Sard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/815,283 external-priority patent/US5290783A/en
Priority claimed from US07/831,429 external-priority patent/US5244902A/en
Priority claimed from US07/893,534 external-priority patent/US5574041A/en
Priority claimed from US07/893,536 external-priority patent/US5703088A/en
Application filed by Individual filed Critical Individual
Publication of CA2126678A1 publication Critical patent/CA2126678A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002126678A 1991-12-27 1992-12-23 Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs Abandoned CA2126678A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US07/815,283 US5290783A (en) 1990-03-16 1991-12-27 Use of spiperone derivatives as immunosuppressant agents
US07/815,283 1991-12-27
US07/831,429 1992-02-05
US07/831,429 US5244902A (en) 1989-08-21 1992-02-05 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US07/893,534 US5574041A (en) 1990-03-16 1992-06-04 Use of spiperone derivatives as immunosuppressant agents
US07/893,536 1992-06-04
US07/893,534 1992-06-04
US07/893,536 US5703088A (en) 1989-08-21 1992-06-04 Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses

Publications (1)

Publication Number Publication Date
CA2126678A1 true CA2126678A1 (fr) 1993-07-08

Family

ID=27505847

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002126678A Abandoned CA2126678A1 (fr) 1991-12-27 1992-12-23 Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs

Country Status (5)

Country Link
EP (1) EP0661972A1 (fr)
JP (1) JPH08500326A (fr)
AU (1) AU3421493A (fr)
CA (1) CA2126678A1 (fr)
WO (1) WO1993012789A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
AU1335397A (en) * 1995-12-21 1997-07-17 Eli Lilly And Company Method for treating dermatitis
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
AU3809999A (en) * 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
CA2496547A1 (fr) * 2002-08-29 2004-03-11 University Of Southampton Traitement de maladies hepatiques
CN100402529C (zh) 2002-09-09 2008-07-16 詹森药业有限公司 用于治疗orl-1受体介导疾病的羟基烷基取代的1,3,8-三氮杂螺[4,5]癸-4-酮衍生物
WO2008067167A1 (fr) 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Sels de 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phényl)-8-(8-méthyl-naphtalén-1-ylméthyl)-1,3,8-triaza-spiro[4,5]décan-4-one
WO2008124209A1 (fr) 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. Dérivés de 1,3,8-trisubstitué-1,3,8-triaza-spiro[4.5]décan-4-one utilisés comme ligands du récepteur orl-i dans le traitement de l'anxiété et de la dépression
JP2020519639A (ja) * 2017-05-12 2020-07-02 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トリアザスピロ［４．５］デカノンによる胃不全麻痺の処置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
ATE135216T1 (de) * 1989-08-21 1996-03-15 Beth Israel Hospital Verwendung von spiperone-derivate zur immunosuppression
EP0520032B1 (fr) * 1990-03-16 1998-09-16 Beth Israel Hospital Association Utilisation de spiperone comme agent immunosuppresseur et anti-inflammatoire

Also Published As

Publication number Publication date
WO1993012789A1 (fr) 1993-07-08
AU3421493A (en) 1993-07-28
EP0661972A1 (fr) 1995-07-12
EP0661972A4 (fr) 1994-10-27
JPH08500326A (ja) 1996-01-16

Similar Documents

Publication Publication Date Title
US5693645A (en) Use of spiperone or spiperone derivatives as immunosuppressant agents
US5290783A (en) Use of spiperone derivatives as immunosuppressant agents
US5703088A (en) Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5631017A (en) Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5244902A (en) Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
CA2126678A1 (fr) Utilisation de spiperone ou de ses derives comme agents immunosuppresseurs
US5637314A (en) Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US20010006972A1 (en) Nk-1 receptor antagonists for the treatment of symptoms of irritable bowel syndrome
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US5484788A (en) Buspirone as a systemic immunosuppressant
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KR20110021946A (ko) 니코틴 수용체 부분 효능제와 아세틸콜린에스테라제 억제제의 조합물, 이를 함유하는 제약 조성물, 및 인지 장애를 치료하는 데에 있어서의 그의 용도
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Legal Events

Date Code Title Description
FZDE Dead