CA2120521A1 - Method for pipetting blood sample - Google Patents
Method for pipetting blood sampleInfo
- Publication number
- CA2120521A1 CA2120521A1 CA002120521A CA2120521A CA2120521A1 CA 2120521 A1 CA2120521 A1 CA 2120521A1 CA 002120521 A CA002120521 A CA 002120521A CA 2120521 A CA2120521 A CA 2120521A CA 2120521 A1 CA2120521 A1 CA 2120521A1
- Authority
- CA
- Canada
- Prior art keywords
- blood
- nozzle tip
- blood plasma
- component
- nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 175
- 239000008280 blood Substances 0.000 title claims abstract description 175
- 238000000034 method Methods 0.000 title claims description 16
- 210000002381 plasma Anatomy 0.000 claims abstract description 32
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 24
- 238000012360 testing method Methods 0.000 claims abstract description 22
- 210000000601 blood cell Anatomy 0.000 claims abstract description 14
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 239000000306 component Substances 0.000 abstract description 31
- 239000012503 blood component Substances 0.000 abstract description 2
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 description 9
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 7
- 150000002500 ions Chemical class 0.000 description 5
- 241001527902 Aratus Species 0.000 description 3
- BHMLFPOTZYRDKA-IRXDYDNUSA-N (2s)-2-[(s)-(2-iodophenoxy)-phenylmethyl]morpholine Chemical compound IC1=CC=CC=C1O[C@@H](C=1C=CC=CC=1)[C@H]1OCCNC1 BHMLFPOTZYRDKA-IRXDYDNUSA-N 0.000 description 2
- 241000518994 Conta Species 0.000 description 2
- 101150073597 DLST gene Proteins 0.000 description 2
- 101100295675 Dictyostelium discoideum odhB gene Proteins 0.000 description 2
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- FYEHYMARPSSOBO-UHFFFAOYSA-N Aurin Chemical group C1=CC(O)=CC=C1C(C=1C=CC(O)=CC=1)=C1C=CC(=O)C=C1 FYEHYMARPSSOBO-UHFFFAOYSA-N 0.000 description 1
- 101100290380 Caenorhabditis elegans cel-1 gene Proteins 0.000 description 1
- 101100453921 Caenorhabditis elegans kin-29 gene Proteins 0.000 description 1
- 241000237074 Centris Species 0.000 description 1
- 241000272470 Circus Species 0.000 description 1
- 101100506443 Danio rerio helt gene Proteins 0.000 description 1
- 241001481828 Glyptocephalus cynoglossus Species 0.000 description 1
- 241001527806 Iti Species 0.000 description 1
- 101150071986 LRAT gene Proteins 0.000 description 1
- 101100268654 Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8) abl6 gene Proteins 0.000 description 1
- 101100270435 Mus musculus Arhgef12 gene Proteins 0.000 description 1
- 101100506445 Mus musculus Helt gene Proteins 0.000 description 1
- 241000795633 Olea <sea slug> Species 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 241000429017 Pectis Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 241001237728 Precis Species 0.000 description 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
- 241000364027 Sinoe Species 0.000 description 1
- 241000193803 Therea Species 0.000 description 1
- 241000534944 Thia Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 101150078644 kinB gene Proteins 0.000 description 1
- PXUQTDZNOHRWLI-OXUVVOBNSA-O malvidin 3-O-beta-D-glucoside Chemical compound COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 PXUQTDZNOHRWLI-OXUVVOBNSA-O 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/103—General features of the devices using disposable tips
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP257642/91 | 1991-10-04 | ||
| JP3257642A JP2725917B2 (ja) | 1991-10-04 | 1991-10-04 | 血液試料の分注方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2120521A1 true CA2120521A1 (en) | 1993-04-15 |
Family
ID=17309080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002120521A Abandoned CA2120521A1 (en) | 1991-10-04 | 1992-10-02 | Method for pipetting blood sample |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5452619A (enrdf_load_stackoverflow) |
| EP (1) | EP0606480A4 (enrdf_load_stackoverflow) |
| JP (1) | JP2725917B2 (enrdf_load_stackoverflow) |
| AU (1) | AU2688792A (enrdf_load_stackoverflow) |
| CA (1) | CA2120521A1 (enrdf_load_stackoverflow) |
| TW (1) | TW221671B (enrdf_load_stackoverflow) |
| WO (1) | WO1993007494A1 (enrdf_load_stackoverflow) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5526546A (en) * | 1993-04-23 | 1996-06-18 | Revlon Consumer Products Corporation | Surface treated applicators having bristles coated with an etched layer ions produced by an ion-producing gas plasma |
| JP3328048B2 (ja) * | 1994-02-25 | 2002-09-24 | 富士写真フイルム株式会社 | 液体の混合方法 |
| US5915282A (en) * | 1995-12-14 | 1999-06-22 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| US5965828A (en) * | 1995-12-14 | 1999-10-12 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| US5723795A (en) * | 1995-12-14 | 1998-03-03 | Abbott Laboratories | Fluid handler and method of handling a fluid |
| AU772487B2 (en) * | 1996-11-01 | 2004-04-29 | University Of Pittsburgh | A method and apparatus for holding cells |
| US6121049A (en) * | 1997-12-05 | 2000-09-19 | Bayer Corporation | Method of verifying aspirated volume in automatic diagnostic system |
| US6060320A (en) * | 1997-12-05 | 2000-05-09 | Bayer Corporation | Method of verifying aspirated volume in automatic diagnostic system |
| ATE370410T1 (de) * | 2000-03-27 | 2007-09-15 | Arkray Inc | Verfahren zum rühren einer flüssigkeit |
| US6709872B1 (en) * | 2000-05-02 | 2004-03-23 | Irm Llc | Method and apparatus for dispensing low nanoliter volumes of liquid while minimizing waste |
| US6393898B1 (en) | 2000-05-25 | 2002-05-28 | Symyx Technologies, Inc. | High throughput viscometer and method of using same |
| US6664067B1 (en) * | 2000-05-26 | 2003-12-16 | Symyx Technologies, Inc. | Instrument for high throughput measurement of material physical properties and method of using same |
| US7470546B2 (en) * | 2000-05-31 | 2008-12-30 | Infineon Technologies Ag | Method and arrangement for taking up a first medium, which is present in a first phase, into a capillary device |
| JP4509473B2 (ja) * | 2000-06-30 | 2010-07-21 | 株式会社日立製作所 | 液体分注方法および装置 |
| US6484556B1 (en) * | 2000-11-13 | 2002-11-26 | Ortho Clinical Diagnostics, Inc. | Thin film detection during fluid aspiration |
| US6857309B2 (en) | 2001-08-24 | 2005-02-22 | Symyx Technologies, Inc. | High throughput mechanical rapid serial property testing of materials libraries |
| US6736017B2 (en) | 2001-08-24 | 2004-05-18 | Symyx Technologies, Inc. | High throughput mechanical rapid serial property testing of materials libraries |
| US6860148B2 (en) | 2001-08-24 | 2005-03-01 | Symyx Technologies, Inc. | High throughput fabric handle screening |
| US6837115B2 (en) * | 2001-08-24 | 2005-01-04 | Symyx Technologies, Inc. | High throughput mechanical rapid serial property testing of materials libraries |
| US6690179B2 (en) * | 2001-08-24 | 2004-02-10 | Symyx Technologies, Inc. | High throughput mechanical property testing of materials libraries using capacitance |
| US6769292B2 (en) * | 2001-08-24 | 2004-08-03 | Symyx Technologies, Inc | High throughput rheological testing of materials |
| US6772642B2 (en) | 2001-08-24 | 2004-08-10 | Damian A. Hajduk | High throughput mechanical property and bulge testing of materials libraries |
| US6650102B2 (en) * | 2001-08-24 | 2003-11-18 | Symyx Technologies, Inc. | High throughput mechanical property testing of materials libraries using a piezoelectric |
| US20030055587A1 (en) * | 2001-09-17 | 2003-03-20 | Symyx Technologies, Inc. | Rapid throughput surface topographical analysis |
| US7013709B2 (en) * | 2002-01-31 | 2006-03-21 | Symyx Technologies, Inc. | High throughput preparation and analysis of plastically shaped material samples |
| US20030203500A1 (en) * | 2002-04-26 | 2003-10-30 | Symyx Technologies, Inc. | High throughput testing of fluid samples using an electric field |
| US7112443B2 (en) * | 2002-10-18 | 2006-09-26 | Symyx Technologies, Inc. | High throughput permeability testing of materials libraries |
| US7396512B2 (en) | 2003-11-04 | 2008-07-08 | Drummond Scientific Company | Automatic precision non-contact open-loop fluid dispensing |
| US7537735B2 (en) * | 2004-05-21 | 2009-05-26 | Biomerieux, Inc. | Aspirator systems having an aspirator tip optical level detector and methods for using the same |
| US7258480B2 (en) * | 2005-01-10 | 2007-08-21 | Dade Behring Inc. | Apparatus for mixing liquid samples using a two dimensional stirring pattern |
| US7998751B2 (en) * | 2005-04-26 | 2011-08-16 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for aspirating and dispensing small liquid samples in an automated clinical analyzer |
| US8192698B2 (en) * | 2006-01-27 | 2012-06-05 | Parker-Hannifin Corporation | Sampling probe, gripper and interface for laboratory sample management systems |
| DE102006017360A1 (de) * | 2006-04-11 | 2007-10-18 | Diasys Diagnostic Systems Gmbh | Verfahren zum Dosieren und Mischen |
| JP4876027B2 (ja) * | 2007-05-30 | 2012-02-15 | 株式会社日立ハイテクノロジーズ | 分注装置 |
| US8726745B2 (en) * | 2007-11-26 | 2014-05-20 | Perkinelmer Health Sciences, Inc. | Fluid handling device with ultrasound sensor and methods and systems using same |
| US8309036B2 (en) * | 2009-05-15 | 2012-11-13 | Gen-Probe Incorporated | Method for separating viscous materials suspended from a pipette |
| US8307697B2 (en) * | 2010-04-14 | 2012-11-13 | Ortho-Clinical Diagnostics, Inc. | Method for estimating viscosity |
| CA2766735C (en) * | 2011-02-07 | 2020-06-02 | Ortho-Clinical Diagnostics, Inc. | Determining conditions in centrifuged blood using measured pressure |
| JP2013007579A (ja) | 2011-06-22 | 2013-01-10 | Seiko Epson Corp | 分注方法 |
| WO2013008502A1 (ja) * | 2011-07-08 | 2013-01-17 | 株式会社日立ハイテクノロジーズ | 固相抽出装置および粘度測定装置 |
| FI20116059A7 (fi) * | 2011-10-28 | 2013-04-29 | Thermo Fisher Scientific Oy | Reagenssipullo, järjestelmä, menetelmä ja laite suljinkorkkien ja vastaavien käsittelemiseksi |
| CN103245774A (zh) * | 2012-02-07 | 2013-08-14 | 奥索临床诊断有限公司 | 使用测定压力确定离心血液中的状况 |
| WO2014017275A1 (ja) * | 2012-07-25 | 2014-01-30 | 株式会社 日立ハイテクノロジーズ | 自動分析装置 |
| WO2016073832A1 (en) * | 2014-11-07 | 2016-05-12 | Theranos, Inc. | Improved methods, devices, and systems for mixing fluids |
| WO2017006969A1 (ja) * | 2015-07-07 | 2017-01-12 | コニカミノルタ株式会社 | 検出装置および検出方法 |
| ES2879813T3 (es) | 2015-09-04 | 2021-11-23 | Qualigen Inc | Sistemas y procedimientos para la verificación de muestras |
| JP6617374B2 (ja) * | 2015-10-30 | 2019-12-11 | コニカミノルタ株式会社 | 送液方法、送液装置及び分析装置 |
| WO2017130359A1 (ja) * | 2016-01-28 | 2017-08-03 | コニカミノルタ株式会社 | 送液方法、ならびにこれを行う検出システムおよび検出装置 |
| WO2019060716A1 (en) * | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
| JP7075213B2 (ja) * | 2017-12-28 | 2022-05-25 | シスメックス株式会社 | 検体測定方法および検体測定装置 |
| WO2019163270A1 (ja) * | 2018-02-20 | 2019-08-29 | ヤマハ発動機株式会社 | 生体対象物のピックアップ装置 |
| JP6814171B2 (ja) * | 2018-03-19 | 2021-01-13 | 株式会社日立ハイテク | 自動分析装置 |
| JP7632654B2 (ja) * | 2021-08-18 | 2025-02-19 | 株式会社島津製作所 | 前処理装置及びその制御方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5519895Y2 (enrdf_load_stackoverflow) * | 1975-12-27 | 1980-05-12 | ||
| JPS5515953A (en) * | 1978-07-19 | 1980-02-04 | Nippon Jiryoku Senko Kk | Simulataneously forming method for activated zinc white and white carbon |
| JPS5694238A (en) * | 1979-12-28 | 1981-07-30 | Hitachi Koki Co Ltd | Extruding device of separated sample |
| JPS57111451A (en) * | 1980-12-29 | 1982-07-10 | Olympus Optical Co Ltd | Dispensing method for particle sample |
| US4671103A (en) * | 1985-04-08 | 1987-06-09 | Exxon Chemical Patents Inc. | Method for determining crude oil fouling by high performance liquid chromatography |
| JP2576956B2 (ja) * | 1987-06-25 | 1997-01-29 | 株式会社 神戸製鋼所 | 産業用ロボツトの回転角検出装置 |
| JP2515920Y2 (ja) * | 1989-04-27 | 1996-11-06 | 株式会社ニッテク | 分注装置 |
| JP2875071B2 (ja) * | 1991-08-09 | 1999-03-24 | オリンパス光学工業株式会社 | 輸血検査用分注装置 |
-
1991
- 1991-10-04 JP JP3257642A patent/JP2725917B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-02 AU AU26887/92A patent/AU2688792A/en not_active Abandoned
- 1992-10-02 WO PCT/JP1992/001281 patent/WO1993007494A1/ja not_active Application Discontinuation
- 1992-10-02 US US08/211,382 patent/US5452619A/en not_active Expired - Fee Related
- 1992-10-02 EP EP92921041A patent/EP0606480A4/en not_active Withdrawn
- 1992-10-02 CA CA002120521A patent/CA2120521A1/en not_active Abandoned
- 1992-10-12 TW TW081108079A patent/TW221671B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| TW221671B (enrdf_load_stackoverflow) | 1994-03-11 |
| EP0606480A1 (en) | 1994-07-20 |
| US5452619A (en) | 1995-09-26 |
| JPH0599932A (ja) | 1993-04-23 |
| JP2725917B2 (ja) | 1998-03-11 |
| WO1993007494A1 (en) | 1993-04-15 |
| AU2688792A (en) | 1993-05-03 |
| EP0606480A4 (en) | 1996-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |