CA2110387A1 - Molecule d'adhesion intercellulaire 3 et ses ligands de fixation - Google Patents

Molecule d'adhesion intercellulaire 3 et ses ligands de fixation

Info

Publication number
CA2110387A1
CA2110387A1 CA002110387A CA2110387A CA2110387A1 CA 2110387 A1 CA2110387 A1 CA 2110387A1 CA 002110387 A CA002110387 A CA 002110387A CA 2110387 A CA2110387 A CA 2110387A CA 2110387 A1 CA2110387 A1 CA 2110387A1
Authority
CA
Canada
Prior art keywords
icam
antibody
binding
fragment
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002110387A
Other languages
English (en)
Inventor
Antonin R. Defougerolles
Timothy A. Springer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Disease Institute Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2110387A1 publication Critical patent/CA2110387A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002110387A 1991-06-11 1992-06-11 Molecule d'adhesion intercellulaire 3 et ses ligands de fixation Abandoned CA2110387A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71287991A 1991-06-11 1991-06-11
US07/712,879 1991-06-11

Publications (1)

Publication Number Publication Date
CA2110387A1 true CA2110387A1 (fr) 1992-12-23

Family

ID=24863928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002110387A Abandoned CA2110387A1 (fr) 1991-06-11 1992-06-11 Molecule d'adhesion intercellulaire 3 et ses ligands de fixation

Country Status (21)

Country Link
EP (1) EP0590051A4 (fr)
JP (1) JP3288042B2 (fr)
KR (2) KR100333120B1 (fr)
CN (1) CN1188528C (fr)
BG (1) BG61682B1 (fr)
BR (1) BR9206142A (fr)
CA (1) CA2110387A1 (fr)
CZ (1) CZ283478B6 (fr)
FI (1) FI935500A (fr)
HU (1) HU217176B (fr)
IE (1) IE921893A1 (fr)
IL (1) IL102176A (fr)
MX (1) MX9202804A (fr)
NO (1) NO317658B1 (fr)
NZ (1) NZ243114A (fr)
RO (1) RO115415B1 (fr)
RU (1) RU2130782C1 (fr)
SK (1) SK279937B6 (fr)
UA (1) UA27763C2 (fr)
WO (1) WO1992022323A1 (fr)
ZA (1) ZA924276B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629162A (en) * 1991-06-11 1997-05-13 The Center For Blood Research Method of identifying agents which modulate ICAM-3 binding to LFA-1
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US5880268A (en) * 1992-01-27 1999-03-09 Icos Corporation Modulators of the interaction between ICAM-R and αd /CD18
EP0578819A4 (fr) * 1992-01-27 1994-10-12 Icos Corp Proteine apparentee a icam.
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
WO1999018441A1 (fr) * 1992-01-27 1999-04-15 Icos Corporation Icam-4 et ses utilisations diagnostiques
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
WO1994017100A1 (fr) * 1993-01-22 1994-08-04 Icos Corporation Proteine apparentee aux molecules d'adhesion intercellulaire
ATE211167T1 (de) * 1993-11-02 2002-01-15 Innogenetics Nv Monoklonale antikörper gegen schaumzellen und ihre pharmazeutische und diagnostische anwendung
US5681699A (en) * 1994-02-11 1997-10-28 Cedars-Sinai Medical Center Methods of diagnosing ulcerative colitis and Crohn's disease
US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
ATE237140T1 (de) * 1997-10-02 2003-04-15 Icos Corp Icam-4 und dessen diagnostische verwendungen
US6630503B1 (en) 1999-08-13 2003-10-07 Biogen, Inc. Cell adhesion inhibitors
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US7691591B2 (en) * 2002-09-20 2010-04-06 Stichting Katholieke Universiteit Methods of identifying and isolating cells expressing DC-sign
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
WO2010062960A2 (fr) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center Méthodes de détermination d'une réceptivité à une thérapie par anti-tnfα lors d’une maladie intestinale inflammatoire
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
GB201016864D0 (en) 2010-10-06 2010-11-17 Univ Aston Therapeutic methods
KR20230109779A (ko) 2013-03-27 2023-07-20 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전
US10316083B2 (en) 2013-07-19 2019-06-11 Cedars-Sinai Medical Center Signature of TL1A (TNFSF15) signaling pathway
KR102464372B1 (ko) 2016-03-17 2022-11-04 세다르스-신나이 메디칼 센터 Rnaset2를 통한 염증성 장 질환의 진단 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232833A (en) * 1989-03-09 1993-05-26 Blood Res Center Intercellular adhesion molecule-2 (icam-2) and functional derivatives thereof

Also Published As

Publication number Publication date
HUT66617A (en) 1994-12-28
NO934491D0 (no) 1993-12-09
BR9206142A (pt) 1994-12-27
UA27763C2 (uk) 2000-10-16
EP0590051A4 (fr) 1994-10-12
FI935500A0 (fi) 1993-12-08
CN1188528C (zh) 2005-02-09
WO1992022323A1 (fr) 1992-12-23
NZ243114A (en) 1995-03-28
IE921893A1 (en) 1992-12-16
ZA924276B (en) 1993-03-31
HU9303529D0 (en) 1994-04-28
HU217176B (hu) 1999-12-28
RO115415B1 (ro) 2000-02-28
AU670243B2 (en) 1996-07-11
CN1069522A (zh) 1993-03-03
RU2130782C1 (ru) 1999-05-27
CZ283478B6 (cs) 1998-04-15
FI935500A (fi) 1994-02-09
AU2237692A (en) 1993-01-12
NO317658B1 (no) 2004-11-29
KR100291844B1 (ko) 2001-09-17
NO934491L (no) 1994-02-11
BG98287A (bg) 1994-08-30
KR100333120B1 (ko) 2002-04-18
CZ270293A3 (en) 1994-08-17
JPH06509706A (ja) 1994-11-02
EP0590051A1 (fr) 1994-04-06
IL102176A (en) 2001-09-13
BG61682B1 (bg) 1998-03-31
IL102176A0 (en) 1993-01-14
JP3288042B2 (ja) 2002-06-04
SK139593A3 (en) 1994-10-05
MX9202804A (es) 1992-12-01
SK279937B6 (sk) 1999-06-11

Similar Documents

Publication Publication Date Title
CA2110387A1 (fr) Molecule d'adhesion intercellulaire 3 et ses ligands de fixation
US5475091A (en) R6-5-D6, an antibody which binds intercellular adhesion molecule-1
JP2763030B2 (ja) 細胞間粘着分子およびその結合性リガンド
AU679506B2 (en) Intercellular adhesion molecules, and their binding ligands
US5891841A (en) Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
EP0387668A1 (fr) Molécule d'adhésion intercellulaire-2 et ses ligands de liaisons
CA2081479A1 (fr) Anticorps chimeriques humanises anti-icam-1, leurs modes de preparation et leur usage
EP0606518B1 (fr) Molécules d'adhésion intercellulaire et leurs ligands de liaison
US5831036A (en) Soluble fragments of human intercellular adhesion molecule-1
US5489533A (en) Isolated nucleic acid molecules encoding ICAM-2
JP3778922B2 (ja) 細胞間粘着分子およびその結合性リガンド
US5565550A (en) Antibodies to ICAM-2, and fragments thereof
US20090035321A1 (en) Intercellular adhesion molecules and their binding ligands
AU670243C (en) Intercellular adhesion molecule-3 and its binding ligands
US6511664B1 (en) Intercellular adhesion molecule—2 and its binding ligands
CA2056143A1 (fr) Le site de liaison mac-1 de l'icam-1

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued