RO115415B1 - Moleculă-3 de adeziune intercelulară (icam-3), moleculă adn recombinant care o codifică, anticorpi ai acesteia, metodă de producere a celulei hibridoma, metode de modulare a funcţiilor biologice, de suprimare, identificare, diagnoză şi compoziţii farmaceutice - Google Patents
Moleculă-3 de adeziune intercelulară (icam-3), moleculă adn recombinant care o codifică, anticorpi ai acesteia, metodă de producere a celulei hibridoma, metode de modulare a funcţiilor biologice, de suprimare, identificare, diagnoză şi compoziţii farmaceuticeInfo
- Publication number
- RO115415B1 RO115415B1 RO93-01672A RO9301672A RO115415B1 RO 115415 B1 RO115415 B1 RO 115415B1 RO 9301672 A RO9301672 A RO 9301672A RO 115415 B1 RO115415 B1 RO 115415B1
- Authority
- RO
- Romania
- Prior art keywords
- icam
- molecule
- intercellular adhesion
- binding
- fragment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71287991A | 1991-06-11 | 1991-06-11 | |
PCT/US1992/004896 WO1992022323A1 (fr) | 1991-06-11 | 1992-06-11 | Molecules d'adhesion intracellulaire icam-3 et leurs ligands de fixation |
Publications (1)
Publication Number | Publication Date |
---|---|
RO115415B1 true RO115415B1 (ro) | 2000-02-28 |
Family
ID=24863928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO93-01672A RO115415B1 (ro) | 1991-06-11 | 1992-06-11 | Moleculă-3 de adeziune intercelulară (icam-3), moleculă adn recombinant care o codifică, anticorpi ai acesteia, metodă de producere a celulei hibridoma, metode de modulare a funcţiilor biologice, de suprimare, identificare, diagnoză şi compoziţii farmaceutice |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0590051A4 (fr) |
JP (1) | JP3288042B2 (fr) |
KR (2) | KR100291844B1 (fr) |
CN (1) | CN1188528C (fr) |
BG (1) | BG61682B1 (fr) |
BR (1) | BR9206142A (fr) |
CA (1) | CA2110387A1 (fr) |
CZ (1) | CZ283478B6 (fr) |
FI (1) | FI935500A (fr) |
HU (1) | HU217176B (fr) |
IE (1) | IE921893A1 (fr) |
IL (1) | IL102176A (fr) |
MX (1) | MX9202804A (fr) |
NO (1) | NO317658B1 (fr) |
NZ (1) | NZ243114A (fr) |
RO (1) | RO115415B1 (fr) |
RU (1) | RU2130782C1 (fr) |
SK (1) | SK279937B6 (fr) |
UA (1) | UA27763C2 (fr) |
WO (1) | WO1992022323A1 (fr) |
ZA (1) | ZA924276B (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629162A (en) * | 1991-06-11 | 1997-05-13 | The Center For Blood Research | Method of identifying agents which modulate ICAM-3 binding to LFA-1 |
US5702917A (en) * | 1992-01-27 | 1997-12-30 | Icos Corporation | Polynucleotides encoding human ICAM-4 |
US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
WO1999018441A1 (fr) * | 1992-01-27 | 1999-04-15 | Icos Corporation | Icam-4 et ses utilisations diagnostiques |
US5811517A (en) * | 1992-01-27 | 1998-09-22 | Icos Corporation | ICAM-related protein variants |
US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
WO1993014776A1 (fr) * | 1992-01-27 | 1993-08-05 | Icos Corporation | Proteine apparentee a icam |
US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
WO1994017100A1 (fr) * | 1993-01-22 | 1994-08-04 | Icos Corporation | Proteine apparentee aux molecules d'adhesion intercellulaire |
AU7940594A (en) * | 1993-11-02 | 1995-05-23 | Innogenetics N.V. | Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use |
US5681699A (en) * | 1994-02-11 | 1997-10-28 | Cedars-Sinai Medical Center | Methods of diagnosing ulcerative colitis and Crohn's disease |
US6884590B1 (en) | 1994-02-11 | 2005-04-26 | Cedars-Sinai Medical Center | Methods of screening for ulcerative colitis and crohn's disease |
US5914112A (en) * | 1996-01-23 | 1999-06-22 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
BR9806294A (pt) * | 1997-10-02 | 2001-09-25 | Icos Corp | Processo de seleção para neuropatologia em um indivìduo |
MXPA02001449A (es) | 1999-08-13 | 2002-07-02 | Biogen Inc | Inhibidores de adhesion de celdas. |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
AU2003278541A1 (en) * | 2002-09-20 | 2004-04-08 | Stichting Katholieke Universiteit | Method of treating rheumatoid arthritis by interfering with expression of dc-sign by macrophages and diagnosis thereof |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
EP2041299A4 (fr) | 2006-07-14 | 2010-01-13 | Aviva Biosciences Corp | Procedes et compositions servant a detecter des cellules rares dans un echantillon biologique |
US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
US9580752B2 (en) | 2008-12-24 | 2017-02-28 | Cedars-Sinai Medical Center | Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy |
GB201016864D0 (en) | 2010-10-06 | 2010-11-17 | Univ Aston | Therapeutic methods |
US10633449B2 (en) | 2013-03-27 | 2020-04-28 | Cedars-Sinai Medical Center | Treatment and reversal of fibrosis and inflammation by inhibition of the TL1A-DR3 signaling pathway |
EP4105236A1 (fr) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anticorps contre tl1a (tnfsf15) pour le traitement des maladies inflammatoires de l'intestin |
JP7082945B2 (ja) | 2016-03-17 | 2022-06-09 | シーダーズ―シナイ メディカル センター | Rnaset2により炎症性腸疾患を診断する方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ245651A (en) * | 1989-03-09 | 1997-06-24 | Blood Res Center | Ligand molecules (e.g. antibodies and fragments) capable of binding to intercellular adhesion molecule-2 (icam-2) and their use |
-
1992
- 1992-06-11 KR KR1019930703828A patent/KR100291844B1/ko not_active IP Right Cessation
- 1992-06-11 CZ CS932702A patent/CZ283478B6/cs not_active IP Right Cessation
- 1992-06-11 RO RO93-01672A patent/RO115415B1/ro unknown
- 1992-06-11 NZ NZ243114A patent/NZ243114A/xx unknown
- 1992-06-11 CN CNB921051263A patent/CN1188528C/zh not_active Expired - Fee Related
- 1992-06-11 RU RU93058655A patent/RU2130782C1/ru not_active IP Right Cessation
- 1992-06-11 BR BR9206142A patent/BR9206142A/pt not_active Application Discontinuation
- 1992-06-11 ZA ZA924276A patent/ZA924276B/xx unknown
- 1992-06-11 JP JP50099993A patent/JP3288042B2/ja not_active Expired - Fee Related
- 1992-06-11 SK SK1395-93A patent/SK279937B6/sk unknown
- 1992-06-11 CA CA002110387A patent/CA2110387A1/fr not_active Abandoned
- 1992-06-11 UA UA93003881A patent/UA27763C2/uk unknown
- 1992-06-11 MX MX9202804A patent/MX9202804A/es not_active Application Discontinuation
- 1992-06-11 IL IL10217692A patent/IL102176A/en not_active IP Right Cessation
- 1992-06-11 WO PCT/US1992/004896 patent/WO1992022323A1/fr not_active Application Discontinuation
- 1992-06-11 EP EP19920914138 patent/EP0590051A4/fr not_active Ceased
- 1992-06-11 KR KR1020007000978A patent/KR100333120B1/ko not_active IP Right Cessation
- 1992-07-01 IE IE189392A patent/IE921893A1/en not_active Application Discontinuation
-
1993
- 1993-12-08 FI FI935500A patent/FI935500A/fi unknown
- 1993-12-09 NO NO934491A patent/NO317658B1/no not_active IP Right Cessation
- 1993-12-10 HU HU9303529A patent/HU217176B/hu not_active IP Right Cessation
- 1993-12-10 BG BG98287A patent/BG61682B1/bg unknown
Also Published As
Publication number | Publication date |
---|---|
CA2110387A1 (fr) | 1992-12-23 |
MX9202804A (es) | 1992-12-01 |
KR100291844B1 (ko) | 2001-09-17 |
EP0590051A4 (fr) | 1994-10-12 |
WO1992022323A1 (fr) | 1992-12-23 |
HU217176B (hu) | 1999-12-28 |
HUT66617A (en) | 1994-12-28 |
IL102176A (en) | 2001-09-13 |
HU9303529D0 (en) | 1994-04-28 |
UA27763C2 (uk) | 2000-10-16 |
FI935500A0 (fi) | 1993-12-08 |
CZ283478B6 (cs) | 1998-04-15 |
SK279937B6 (sk) | 1999-06-11 |
BG98287A (bg) | 1994-08-30 |
NO934491D0 (no) | 1993-12-09 |
ZA924276B (en) | 1993-03-31 |
AU670243B2 (en) | 1996-07-11 |
CN1069522A (zh) | 1993-03-03 |
NO934491L (no) | 1994-02-11 |
SK139593A3 (en) | 1994-10-05 |
BG61682B1 (bg) | 1998-03-31 |
NZ243114A (en) | 1995-03-28 |
NO317658B1 (no) | 2004-11-29 |
FI935500A (fi) | 1994-02-09 |
EP0590051A1 (fr) | 1994-04-06 |
IL102176A0 (en) | 1993-01-14 |
BR9206142A (pt) | 1994-12-27 |
KR100333120B1 (ko) | 2002-04-18 |
CN1188528C (zh) | 2005-02-09 |
RU2130782C1 (ru) | 1999-05-27 |
AU2237692A (en) | 1993-01-12 |
JPH06509706A (ja) | 1994-11-02 |
JP3288042B2 (ja) | 2002-06-04 |
CZ270293A3 (en) | 1994-08-17 |
IE921893A1 (en) | 1992-12-16 |
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