CA2109099C - Methode et dispositif de fabrication d'un dispositif d'administration transdermique de medicaments - Google Patents
Methode et dispositif de fabrication d'un dispositif d'administration transdermique de medicaments Download PDFInfo
- Publication number
- CA2109099C CA2109099C CA002109099A CA2109099A CA2109099C CA 2109099 C CA2109099 C CA 2109099C CA 002109099 A CA002109099 A CA 002109099A CA 2109099 A CA2109099 A CA 2109099A CA 2109099 C CA2109099 C CA 2109099C
- Authority
- CA
- Canada
- Prior art keywords
- roller
- cutting
- pressure
- web
- anvil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 48
- 229940079593 drug Drugs 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 40
- 238000005520 cutting process Methods 0.000 claims abstract description 271
- 239000010410 layer Substances 0.000 claims abstract description 53
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 32
- 238000013271 transdermal drug delivery Methods 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims description 18
- 239000012858 resilient material Substances 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims 4
- 239000012790 adhesive layer Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000035515 penetration Effects 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 description 16
- 230000001070 adhesive effect Effects 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 11
- 230000002093 peripheral effect Effects 0.000 description 11
- 229920001971 elastomer Polymers 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 230000009471 action Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 238000004513 sizing Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 2
- 229920001821 foam rubber Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- -1 release liner Substances 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26D—CUTTING; DETAILS COMMON TO MACHINES FOR PERFORATING, PUNCHING, CUTTING-OUT, STAMPING-OUT OR SEVERING
- B26D9/00—Cutting apparatus combined with punching or perforating apparatus or with dissimilar cutting apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/38—Cutting-out; Stamping-out
- B26F1/384—Cutting-out; Stamping-out using rotating drums
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/38—Cutting-out; Stamping-out
- B26F1/44—Cutters therefor; Dies therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/38—Cutting-out; Stamping-out
- B26F1/44—Cutters therefor; Dies therefor
- B26F2001/4472—Cutting edge section features
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
- B26F1/38—Cutting-out; Stamping-out
- B26F1/44—Cutters therefor; Dies therefor
- B26F2001/4481—Cutters therefor; Dies therefor having special lateral or edge outlines or special surface shapes, e.g. apertures
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Forests & Forestry (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69135491A | 1991-04-25 | 1991-04-25 | |
| US691,354 | 1991-04-25 | ||
| PCT/US1992/003326 WO1992019451A1 (fr) | 1991-04-25 | 1992-04-24 | Procede et appareil permettant de former un systeme transdermique d'apport de medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2109099A1 CA2109099A1 (fr) | 1992-10-26 |
| CA2109099C true CA2109099C (fr) | 2002-02-19 |
Family
ID=24776217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002109099A Expired - Lifetime CA2109099C (fr) | 1991-04-25 | 1992-04-24 | Methode et dispositif de fabrication d'un dispositif d'administration transdermique de medicaments |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0592481A1 (fr) |
| AU (1) | AU2004092A (fr) |
| CA (1) | CA2109099C (fr) |
| SG (1) | SG43349A1 (fr) |
| WO (1) | WO1992019451A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9402109U1 (de) * | 1994-02-09 | 1994-03-31 | Maartens Kleinmetaal B.V., Haarlem | Rotationsschneidwerkzeug |
| US5826475A (en) * | 1996-01-26 | 1998-10-27 | Kimberly-Clark Worldwide, Inc. | Knife shaft assembly |
| AU1688397A (en) * | 1996-01-26 | 1997-08-20 | Kimberly-Clark Worldwide, Inc. | A knife shaft assembly |
| US6055897A (en) * | 1996-06-21 | 2000-05-02 | Kimberly-Clark Worldwide, Inc. | Die cutting insert for a rotary die cutter and the die itself |
| US6250189B1 (en) * | 1996-06-21 | 2001-06-26 | Kimberly-Clark Worldwide, Inc. | Rotary die cutter |
| DE19650329A1 (de) * | 1996-12-04 | 1998-06-10 | Hexal Ag | Flächiges selbsthaftendes Wirkstoffpflaster |
| KR19980050583A (ko) * | 1996-12-21 | 1998-09-15 | 김준웅 | 약물 경피투여제의 제조장치 |
| GB2333736B (en) * | 1998-01-30 | 2000-06-14 | Really Useful Games Company Li | Methods of manufacture of puzzle pieces |
| DE19834104A1 (de) * | 1998-07-29 | 2000-02-03 | Aichele Werkzeuge Gmbh & Co Kg | Schneidvorrichtung |
| DE10044705C1 (de) | 2000-09-09 | 2002-02-21 | Aichele Werkzeuge Gmbh | Rotationsschneidvorrichtung |
| SE0950362A1 (sv) * | 2009-05-20 | 2010-11-21 | Moelnlycke Health Care Ab | Metod för att tillverka ett filmförband |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| CA2916183C (fr) | 2013-07-03 | 2022-03-29 | Lts Lohmann Therapie-Systeme Ag | Systeme therapeutique transdermique dote d'un composant electronique |
| WO2015177204A1 (fr) | 2014-05-20 | 2015-11-26 | Lts Lohmann Therapie-Systeme Ag | Système d'administration transdermique contenant de la rotigotine |
| CA2948221C (fr) | 2014-05-20 | 2022-11-22 | Lts Lohmann Therapie-Systeme Ag | Systeme d'administration transdermique comprenant un mediateur d'interface |
| EP3145503A1 (fr) | 2014-05-20 | 2017-03-29 | LTS Lohmann Therapie-Systeme AG | Méthode de régulation de libération d'agent actif dans un système d'administration transdermique |
| CN111214755B (zh) * | 2019-10-31 | 2024-05-28 | 广州新济生物医药研究院有限公司 | 芯片处理机构、设备及其操作方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1963393A (en) * | 1932-06-13 | 1934-06-19 | Woodall Industries Inc | Laminated panel |
| US3006793A (en) * | 1960-08-19 | 1961-10-31 | Avery Adhesive Products Inc | Adhesive products |
| US3552244A (en) * | 1969-04-17 | 1971-01-05 | Kilby P Smith Jr | Rotary die stripping |
| US3749626A (en) * | 1971-06-28 | 1973-07-31 | H Buck | Rotary die apparatus and process for manufacturing labels or the like |
| US3786732A (en) * | 1972-02-16 | 1974-01-22 | Westvaco Corp | Cutting and scoring die |
| DE2853006C2 (de) * | 1978-12-07 | 1993-12-16 | Uniroyal Englebert Gmbh | Fahrzeugluftreifen |
| US5032207A (en) * | 1988-03-04 | 1991-07-16 | Noven Pharmaceuticals, Inc. | One-step method for forming a pressure-sensitive adhesive transdermal drug device |
| WO1991017027A1 (fr) * | 1990-05-10 | 1991-11-14 | Buck Byron L | Systeme de decoupage a matrices rotatives pour matiere en feuille |
-
1992
- 1992-04-24 AU AU20040/92A patent/AU2004092A/en not_active Abandoned
- 1992-04-24 WO PCT/US1992/003326 patent/WO1992019451A1/fr not_active Application Discontinuation
- 1992-04-24 CA CA002109099A patent/CA2109099C/fr not_active Expired - Lifetime
- 1992-04-24 EP EP92912870A patent/EP0592481A1/fr not_active Withdrawn
- 1992-04-24 SG SG1996009225A patent/SG43349A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004092A (en) | 1992-12-21 |
| WO1992019451A1 (fr) | 1992-11-12 |
| CA2109099A1 (fr) | 1992-10-26 |
| EP0592481A4 (fr) | 1994-02-24 |
| EP0592481A1 (fr) | 1994-04-20 |
| SG43349A1 (en) | 1997-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20120424 |