CA2096006A1 - Intraretinal delivery and withdrawal instruments - Google Patents
Intraretinal delivery and withdrawal instrumentsInfo
- Publication number
- CA2096006A1 CA2096006A1 CA002096006A CA2096006A CA2096006A1 CA 2096006 A1 CA2096006 A1 CA 2096006A1 CA 002096006 A CA002096006 A CA 002096006A CA 2096006 A CA2096006 A CA 2096006A CA 2096006 A1 CA2096006 A1 CA 2096006A1
- Authority
- CA
- Canada
- Prior art keywords
- tip
- eye
- instrument
- intraocular
- distal end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims abstract description 42
- 230000035515 penetration Effects 0.000 claims abstract description 21
- 238000003780 insertion Methods 0.000 claims abstract description 17
- 230000037431 insertion Effects 0.000 claims abstract description 17
- 210000004027 cell Anatomy 0.000 claims description 37
- 210000001525 retina Anatomy 0.000 claims description 27
- 230000002207 retinal effect Effects 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 13
- 239000004033 plastic Substances 0.000 claims description 12
- 229920003023 plastic Polymers 0.000 claims description 12
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 230000013011 mating Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims 3
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 abstract description 5
- 210000001508 eye Anatomy 0.000 description 57
- 238000002347 injection Methods 0.000 description 22
- 239000007924 injection Substances 0.000 description 22
- 238000002054 transplantation Methods 0.000 description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 8
- 241000700159 Rattus Species 0.000 description 6
- 210000003786 sclera Anatomy 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000003161 choroid Anatomy 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 208000032984 Intraoperative Complications Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000035965 Postoperative Complications Diseases 0.000 description 2
- 208000002367 Retinal Perforations Diseases 0.000 description 2
- 206010038848 Retinal detachment Diseases 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 229910000771 Vitallium Inorganic materials 0.000 description 2
- 238000001949 anaesthesia Methods 0.000 description 2
- 238000010420 art technique Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000009540 indirect ophthalmoscopy Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 210000003733 optic disk Anatomy 0.000 description 2
- 238000000399 optical microscopy Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000004264 retinal detachment Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 229910052715 tantalum Inorganic materials 0.000 description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000000602 vitallium Substances 0.000 description 2
- SNYUHPPZINRDSG-UHFFFAOYSA-N 1-(oxiran-2-ylmethyl)-4-[1-(oxiran-2-ylmethyl)piperidin-4-yl]piperidine Chemical compound C1CC(C2CCN(CC3OC3)CC2)CCN1CC1CO1 SNYUHPPZINRDSG-UHFFFAOYSA-N 0.000 description 1
- 235000006696 Catha edulis Nutrition 0.000 description 1
- 240000007681 Catha edulis Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000006069 Corneal Opacity Diseases 0.000 description 1
- 208000001351 Epiretinal Membrane Diseases 0.000 description 1
- 208000001951 Fetal Death Diseases 0.000 description 1
- 206010055690 Foetal death Diseases 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 206010057765 Procedural complication Diseases 0.000 description 1
- KCLANYCVBBTKTO-UHFFFAOYSA-N Proparacaine Chemical compound CCCOC1=CC=C(C(=O)OCCN(CC)CC)C=C1N KCLANYCVBBTKTO-UHFFFAOYSA-N 0.000 description 1
- 208000037111 Retinal Hemorrhage Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010042618 Surgical procedure repeated Diseases 0.000 description 1
- BGDKAVGWHJFAGW-UHFFFAOYSA-N Tropicamide Chemical group C=1C=CC=CC=1C(CO)C(=O)N(CC)CC1=CC=NC=C1 BGDKAVGWHJFAGW-UHFFFAOYSA-N 0.000 description 1
- 206010064996 Ulcerative keratitis Diseases 0.000 description 1
- 206010046851 Uveitis Diseases 0.000 description 1
- 241001255741 Vanna Species 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 206010063942 Vitreous loss Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000002718 aborted fetus Anatomy 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 229940087458 alcaine Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- HOQPTLCRWVZIQZ-UHFFFAOYSA-H bis[[2-(5-hydroxy-4,7-dioxo-1,3,2$l^{2}-dioxaplumbepan-5-yl)acetyl]oxy]lead Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HOQPTLCRWVZIQZ-UHFFFAOYSA-H 0.000 description 1
- ZFXVRMSLJDYJCH-UHFFFAOYSA-N calcium magnesium Chemical compound [Mg].[Ca] ZFXVRMSLJDYJCH-UHFFFAOYSA-N 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 231100000269 corneal opacity Toxicity 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- OGGXGZAMXPVRFZ-UHFFFAOYSA-M dimethylarsinate Chemical compound C[As](C)([O-])=O OGGXGZAMXPVRFZ-UHFFFAOYSA-M 0.000 description 1
- 238000009539 direct ophthalmoscopy Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 231100000479 fetal death Toxicity 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 229940048282 ketamine 100 mg/ml Drugs 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- FKHVEXUWEQFKCJ-UHFFFAOYSA-L magnesium;sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione;2,2,2-trichloroethane-1,1-diol;sulfate Chemical compound [Na+].[Mg+2].[O-]S([O-])(=O)=O.OC(O)C(Cl)(Cl)Cl.CCCC(C)C1(CC)C(=O)NC(=O)NC1=O FKHVEXUWEQFKCJ-UHFFFAOYSA-L 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940087766 mydriacyl Drugs 0.000 description 1
- 229940105623 neo-synephrine Drugs 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 210000000608 photoreceptor cell Anatomy 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000011205 postoperative examination Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 229940069575 rompun Drugs 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/613,165 US5273530A (en) | 1990-11-14 | 1990-11-14 | Intraretinal delivery and withdrawal instruments |
| US613,165 | 1990-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2096006A1 true CA2096006A1 (en) | 1992-05-15 |
Family
ID=24456138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002096006A Abandoned CA2096006A1 (en) | 1990-11-14 | 1991-11-13 | Intraretinal delivery and withdrawal instruments |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5273530A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0557445A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH06505647A (cg-RX-API-DMAC7.html) |
| AU (1) | AU9062891A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2096006A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1992008406A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817075A (en) * | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
| SG49267A1 (en) * | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
| US6045791A (en) * | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
| CA2158443C (en) * | 1993-03-16 | 2003-11-25 | Stephen E. Hughes | Method for preparation and transplantation of volute grafts and surgical instrument therefor |
| US5868728A (en) * | 1995-02-28 | 1999-02-09 | Photogenesis, Inc. | Medical linear actuator for surgical delivery, manipulation, and extraction |
| US5827216A (en) * | 1995-06-07 | 1998-10-27 | Cormedics Corp. | Method and apparatus for accessing the pericardial space |
| US5997528A (en) * | 1996-08-29 | 1999-12-07 | Bausch & Lomb Surgical, Inc. | Surgical system providing automatic reconfiguration |
| US6086576A (en) * | 1996-08-29 | 2000-07-11 | Bausch & Lomb Surgical, Inc. | Automatically switching the termination of a communications bus |
| US6251113B1 (en) | 1996-08-29 | 2001-06-26 | Bausch & Lomb Surgical, Inc. | Ophthalmic microsurgical system employing surgical module employing flash EEPROM and reprogrammable modules |
| US5910139A (en) * | 1996-08-29 | 1999-06-08 | Storz Instrument Co. | Numeric keypad simulated on touchscreen |
| US6117126A (en) * | 1996-08-29 | 2000-09-12 | Bausch & Lomb Surgical, Inc. | Surgical module with independent microprocessor-based communication |
| JP3022389B2 (ja) * | 1997-03-14 | 2000-03-21 | 株式会社イナミ | メンブレンイレーザー |
| US6055458A (en) * | 1997-08-28 | 2000-04-25 | Bausch & Lomb Surgical, Inc. | Modes/surgical functions |
| US6051011A (en) * | 1997-08-28 | 2000-04-18 | Bausch & Lomb Surgical, Inc. | Surgical handpiece |
| US6024719A (en) * | 1998-07-06 | 2000-02-15 | Morris; Robert E | Method and apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) seperation (FILMS) |
| AU765034B2 (en) * | 1998-07-06 | 2003-09-04 | Robert E Morris | Method and apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) separation (films) |
| US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
| US6378526B1 (en) * | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| KR100312659B1 (ko) * | 1998-09-18 | 2002-02-19 | 하권익 | 망막하주사기 |
| CA2358296A1 (en) * | 1999-01-05 | 2000-07-13 | Anthony P. Adamis | Targeted transscleral controlled release drug delivery to the retina and choroid |
| US6389317B1 (en) * | 2000-03-31 | 2002-05-14 | Optobionics Corporation | Multi-phasic microphotodetector retinal implant with variable voltage and current capability |
| US20040039401A1 (en) * | 2000-03-31 | 2004-02-26 | Chow Alan Y. | Implant instrument |
| US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
| US20030171722A1 (en) * | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
| US7122042B2 (en) * | 2001-03-15 | 2006-10-17 | Lorusso Frank J | Apparatuses and methods for transcleral cautery and subretinal drainage |
| WO2002080811A2 (en) | 2001-04-07 | 2002-10-17 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| US7037943B2 (en) | 2001-04-10 | 2006-05-02 | Optobionics Corporation | Retinal treatment method |
| US7795218B2 (en) | 2001-04-12 | 2010-09-14 | Bioaxone Therapeutique Inc. | ADP-ribosyl transferase fusion variant proteins |
| JP2004536631A (ja) | 2001-05-03 | 2004-12-09 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 移植可能な薬物送達デバイスおよびその使用 |
| US7485113B2 (en) * | 2001-06-22 | 2009-02-03 | Johns Hopkins University | Method for drug delivery through the vitreous humor |
| US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
| KR100431454B1 (ko) * | 2001-10-15 | 2004-05-14 | 사회복지법인삼성생명공익재단(삼성서울병원) | 망막하 주사기 |
| US9301875B2 (en) | 2002-04-08 | 2016-04-05 | Glaukos Corporation | Ocular disorder treatment implants with multiple opening |
| AU2003217531A1 (en) * | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| FR2839454A1 (fr) * | 2002-05-07 | 2003-11-14 | Primebiotech | Dispositif pour la micro-injection de liquide en milieu confine |
| WO2004026347A2 (en) * | 2002-09-17 | 2004-04-01 | Iscience Surgical Corporation | Apparatus and method for surgical bypass of aqueous humor |
| WO2004028477A2 (en) * | 2002-09-29 | 2004-04-08 | Surmodics, Inc. | Methods for treatment and/or prevention of retinal disease |
| US20060167435A1 (en) * | 2003-02-18 | 2006-07-27 | Adamis Anthony P | Transscleral drug delivery device and related methods |
| US20040199130A1 (en) * | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
| KR20060130648A (ko) * | 2004-01-12 | 2006-12-19 | 아이싸이언스 인터벤셔날 코포레이션 | 점성 물질용 인젝터 |
| US20100173866A1 (en) * | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
| EP2468327A1 (en) * | 2004-04-29 | 2012-06-27 | iScience Interventional Corporation | Apparatus and method for surgical enhancement of aqueous humor drainage |
| WO2006014484A2 (en) * | 2004-07-02 | 2006-02-09 | Surmodics, Inc. | Methods and devices for the treatment of ocular conditions |
| WO2006110487A1 (en) | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Sustained release implants for subretinal delivery |
| US20070005016A1 (en) * | 2005-06-20 | 2007-01-04 | Williams David F | Ocular injection device and method |
| US8591457B2 (en) * | 2005-08-10 | 2013-11-26 | Alza Corporation | Method for making a needle-free jet injection drug delivery device |
| JP4358821B2 (ja) * | 2005-12-15 | 2009-11-04 | オリンパス株式会社 | 被検体内導入装置 |
| US7544371B2 (en) * | 2005-12-20 | 2009-06-09 | Bausch + Lomb Incorporated | Drug delivery systems |
| US20070148244A1 (en) * | 2005-12-22 | 2007-06-28 | Kunzler Jay F | Drug delivery systems |
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