CA2094122A1 - Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique - Google Patents

Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique

Info

Publication number
CA2094122A1
CA2094122A1 CA002094122A CA2094122A CA2094122A1 CA 2094122 A1 CA2094122 A1 CA 2094122A1 CA 002094122 A CA002094122 A CA 002094122A CA 2094122 A CA2094122 A CA 2094122A CA 2094122 A1 CA2094122 A1 CA 2094122A1
Authority
CA
Canada
Prior art keywords
acid derivatives
compression method
direct compression
cephalosporanic acid
preparing pills
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002094122A
Other languages
English (en)
Other versions
CA2094122C (fr
Inventor
Jean-Louis Laly
Roberto Lombardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2094122A1 publication Critical patent/CA2094122A1/fr
Application granted granted Critical
Publication of CA2094122C publication Critical patent/CA2094122C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2094122 9208463 PCTABS00130 La présente invention concerne un nouveau procédé de préparation de comprimés dérivés de l'acide acylamino-7 céphalosporanique obtenus par compression directe d'un mélange contenant ledit acide en quantité pondérale comprise entre 20 et 90 % par rapport à la masse globale du comprimé. L'invention concerne aussi les comprimés obtenus par le présent procédé.
CA002094122A 1990-11-15 1991-11-08 Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique Expired - Lifetime CA2094122C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9014210A FR2669221B1 (fr) 1990-11-15 1990-11-15 Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique.
FR9014210 1990-11-15
PCT/FR1991/000872 WO1992008463A1 (fr) 1990-11-15 1991-11-08 Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique

Publications (2)

Publication Number Publication Date
CA2094122A1 true CA2094122A1 (fr) 1992-05-16
CA2094122C CA2094122C (fr) 2004-07-20

Family

ID=9402216

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002094122A Expired - Lifetime CA2094122C (fr) 1990-11-15 1991-11-08 Procede de preparation par compression directe de comprimes de derives de l'acide cephalosporanique

Country Status (11)

Country Link
US (1) US5514383A (fr)
EP (1) EP0557389B1 (fr)
JP (1) JP3253074B2 (fr)
KR (1) KR100226386B1 (fr)
AT (1) ATE111734T1 (fr)
CA (1) CA2094122C (fr)
DE (1) DE69104220T2 (fr)
DK (1) DK0557389T3 (fr)
ES (1) ES2060417T3 (fr)
FR (1) FR2669221B1 (fr)
WO (1) WO1992008463A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399356A (en) * 1994-03-24 1995-03-21 The Procter & Gamble Company Process for making solid dose forms containing bismuth
ES2079327B1 (es) * 1994-12-13 1996-08-01 Lilly Sa Formulaciones farmaceuticas de cefaclor.
PT800384E (pt) * 1994-12-14 2001-06-29 Enbalt Trading Ltd Metodo para a preparacao de um comprimido farmaceutico
DK0890359T3 (da) * 1996-02-29 2002-07-01 Fujisawa Pharmaceutical Co Beta-Lactam-antibiotikumholdige tabletter og fremgangsmåde til fremstilling deraf
TWI225402B (en) 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
US5735891A (en) * 1996-12-02 1998-04-07 Sulzer Intermedics Inc. Self-clamping anchoring sleeve
AU1232500A (en) * 1998-10-30 2000-05-22 Fuisz International Ltd. Improved amoxycillin and clavulanate composition
KR20030078105A (ko) * 2002-03-28 2003-10-08 (주)다산메디켐 제약 및 식품산업의 정제 제조시 반드시 거쳐야 하는공정인 타정(정제의 제조) 공정에서 타정을 위한 분체혼합물의 유동성을 개선하고 타정 공정시 발생되는타정장애 중 특히 타정물이 타정기 또는 타정펀치에 붙든현상인 점착성 발생을 없앤 제약산업에서 사용될 수 있는고형제제를 위한 직타용 부형제의 새로운 조성물에관한것이다.
US7803402B2 (en) * 2002-07-06 2010-09-28 Sanjeev Khandelwal Pharmaceutical preparations
WO2005107703A1 (fr) * 2004-05-10 2005-11-17 Lupin Ltd. Formulation pharmaceutique de cefixime pour biodisponibilite amelioree
CN110041346B (zh) * 2019-04-17 2022-06-07 广东立国制药有限公司 一种低成本的头孢克肟的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR208171A1 (es) * 1972-09-29 1976-12-09 Ciba Geigy Ag Procedimiento para la obtencion de nuevos derivados del acido cef-3-em-4-carboxilico
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
JPH01149728A (ja) * 1987-12-04 1989-06-12 Fujisawa Pharmaceut Co Ltd 抗潰瘍剤
JPH01242589A (ja) * 1988-03-22 1989-09-27 Fujisawa Pharmaceut Co Ltd セフエム化合物
IL94946A0 (en) * 1989-07-13 1991-06-10 Eisai Co Ltd 3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0557389A1 (fr) 1993-09-01
DE69104220D1 (de) 1994-10-27
FR2669221A1 (fr) 1992-05-22
ATE111734T1 (de) 1994-10-15
EP0557389B1 (fr) 1994-09-21
CA2094122C (fr) 2004-07-20
KR930702004A (ko) 1993-09-08
US5514383A (en) 1996-05-07
DK0557389T3 (da) 1994-10-17
FR2669221B1 (fr) 1993-01-15
ES2060417T3 (es) 1994-11-16
KR100226386B1 (ko) 1999-10-15
WO1992008463A1 (fr) 1992-05-29
JPH06502420A (ja) 1994-03-17
DE69104220T2 (de) 1995-01-26
JP3253074B2 (ja) 2002-02-04

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