CA2093659A1 - Sequence de l'adn encodant l'.alpha.-lactalbumine bovine et methode d'utilisation - Google Patents

Sequence de l'adn encodant l'.alpha.-lactalbumine bovine et methode d'utilisation

Info

Publication number
CA2093659A1
CA2093659A1 CA2093659A CA2093659A CA2093659A1 CA 2093659 A1 CA2093659 A1 CA 2093659A1 CA 2093659 A CA2093659 A CA 2093659A CA 2093659 A CA2093659 A CA 2093659A CA 2093659 A1 CA2093659 A1 CA 2093659A1
Authority
CA
Canada
Prior art keywords
alpha
lactalbumin
dna sequence
methods
sequence encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2093659A
Other languages
English (en)
Other versions
CA2093659C (fr
Inventor
Gregory T. Bleck
Robert D. Bremel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Milk Marketing Board Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2093659A1 publication Critical patent/CA2093659A1/fr
Application granted granted Critical
Publication of CA2093659C publication Critical patent/CA2093659C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention concerne l'utilisation d'une protéine de lactalbumine-alpha à spécificité mammaire pour produire des protéines de recombinaison dans le lait des mammifères. Cette invention concerne également le mammifère modifié par génie génétique qui produit le produit de recombinaison désiré dans son lait, ainsi que les produits fabriqués par le mammifère modifié par génie génétique, y compris la composition modifiée du lait et la semence qui renferme la séquence d'ADN de la protéine de lactalbumine-alpha désirée.
CA002093659A 1991-08-13 1992-08-06 Sequence de l'adn encodant l'.alpha.-lactalbumine bovine et methode d'utilisation Expired - Lifetime CA2093659C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74476591A 1991-08-13 1991-08-13
US744,765 1991-08-13
PCT/US1992/006549 WO1993004165A1 (fr) 1991-08-13 1992-08-06 SEQUENCE D'ADN CODANT LA LACTALBUMINE-α BOVINE ET PROCEDES D'UTILISATION

Publications (2)

Publication Number Publication Date
CA2093659A1 true CA2093659A1 (fr) 1993-02-14
CA2093659C CA2093659C (fr) 2001-01-16

Family

ID=24993913

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093659A Expired - Lifetime CA2093659C (fr) 1991-08-13 1992-08-06 Sequence de l'adn encodant l'.alpha.-lactalbumine bovine et methode d'utilisation

Country Status (11)

Country Link
US (2) US5530177A (fr)
EP (1) EP0555435B1 (fr)
JP (1) JP3698369B2 (fr)
AT (1) ATE185596T1 (fr)
AU (1) AU663101B2 (fr)
CA (1) CA2093659C (fr)
DE (1) DE69230135T2 (fr)
DK (1) DK0555435T3 (fr)
IL (1) IL102783A0 (fr)
NZ (1) NZ243930A (fr)
WO (1) WO1993004165A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5374523A (en) * 1992-08-10 1994-12-20 Monsanto Company Allelic variants of bovine somatotropin gene:genetic marker for superior milk production in bovine
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
AU1454495A (en) * 1993-12-29 1995-07-17 Gene Pharming Europe Bv Recombinant production of modified proteins lacking certain amino acids
GB9425326D0 (en) * 1994-12-15 1995-02-15 Ppl Therapeutics Scotland Ltd Gene constructs
US5780009A (en) * 1995-01-20 1998-07-14 Nexia Biotechnologies, Inc. Direct gene transfer into the ruminant mammary gland
US5907080A (en) * 1995-11-30 1999-05-25 Nexia Biotechnologies, Inc. Method for development of transgenic dwarf goats
US6353151B1 (en) 1996-09-26 2002-03-05 University Technology Corporation Transgenic model for heart failure
US5968809A (en) * 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6308170B1 (en) * 1997-07-25 2001-10-23 Affymetrix Inc. Gene expression and evaluation system
AU9162398A (en) * 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Process for producing insulin precursor proteins
GB9718908D0 (en) 1997-09-05 1997-11-12 Rowett Research Services Limit Proteins
US6593463B1 (en) * 1997-10-20 2003-07-15 Genzyme Transgenics Corporation Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems
US20030224415A1 (en) * 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
EP2151493B1 (fr) * 2000-07-03 2012-06-13 Catalent Pharma Solutions, LLC Cellules-hôte avec multiples vecteurs intégratifs
US20040235173A1 (en) * 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
US6852510B2 (en) 2000-07-03 2005-02-08 Gala Design Inc Host cells containing multiple integrating vectors
CA2413156C (fr) * 2000-07-03 2009-08-18 Gala Design, Inc. Vecteurs d'expression
US6677500B2 (en) 2000-08-15 2004-01-13 Board Of Trustees Of The University Of Illinois Ungulates expressing exogenous IGF-I in their milk
CA2471504C (fr) 2002-01-07 2014-05-20 Euroscreen S.A. Ligand du recepteur gpr43 couple a une proteine g et utilisations de ce ligand
US7384738B2 (en) * 2002-03-28 2008-06-10 Bremel Robert D Retrovirus-based genomic screening
US20040038304A1 (en) * 2002-03-28 2004-02-26 Gala Design, Inc. Antibody libraries
GB0314856D0 (en) 2003-06-25 2003-07-30 Unitargeting Res As Protein expression system
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
EP1720888A4 (fr) 2004-02-20 2009-09-16 Burnham Inst Glucose antimicrobien et procedes de fabrication
JP2006168685A (ja) * 2004-12-20 2006-06-29 Yamaha Marine Co Ltd 船外機

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001648A1 (fr) * 1986-08-28 1988-03-10 Immunex Corporation Expression de proteines heterologues par des mammiferes transgeniques en lactation
ES2090299T3 (es) * 1989-12-01 1996-10-16 Pharming Bv Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos.

Also Published As

Publication number Publication date
JPH06502550A (ja) 1994-03-24
DE69230135D1 (de) 1999-11-18
IL102783A0 (en) 1993-01-31
AU663101B2 (en) 1995-09-28
WO1993004165A1 (fr) 1993-03-04
CA2093659C (fr) 2001-01-16
DK0555435T3 (da) 2000-04-25
DE69230135T2 (de) 2000-06-21
NZ243930A (en) 1995-02-24
AU2411992A (en) 1993-03-16
EP0555435A4 (fr) 1995-05-24
ATE185596T1 (de) 1999-10-15
EP0555435B1 (fr) 1999-10-13
JP3698369B2 (ja) 2005-09-21
US5850000A (en) 1998-12-15
EP0555435A1 (fr) 1993-08-18
US5530177A (en) 1996-06-25

Similar Documents

Publication Publication Date Title
CA2093659A1 (fr) Sequence de l'adn encodant l'.alpha.-lactalbumine bovine et methode d'utilisation
BG104149A (en) Interleukin-18-binding proteins, methods for their preparation and administration
EP0347431A4 (en) Expression of proteins in milk
AU6733487A (en) Mammalian interleukin-4
GB2197324B (en) Process for the production of a polypeptide
IL94183A (en) cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
AU9052891A (en) Proteins with changed epitopes and methods for the production thereof
HK1014030A1 (en) Cd2-binding domain of lymphocyte function associated antigen 3
MY105080A (en) Heat-labile toxin b subunit fusion proteins.
HUT62031A (en) Process for producing recombinant aprotinin derivatives and pharmaceutical compositions comprising same
NZ335633A (en) Production of recombinant H. pylori polypeptides for treatment and diagnosis of H. pylori related diseases
EP0146903A3 (fr) Production d'un vecteur qui encode un interféron hybride
IE890719L (en) Modified proteins
EP0490383A3 (en) Peptides of the hiv-gag protein, their preparation and use
AU637589B2 (en) Ancrod proteins, their production and use
ATE487735T1 (de) Säugetier milchwachstumsfaktor
EP0723016A3 (fr) Facteur d'activation des leukocytes
DK0540560T3 (da) Ancrod-lignende proteiner, fremstilling og anvendelse deraf
ATE201046T1 (de) Polypeptide und dafür kodierende dns, die mit humanen malariaparasiten assoziiert sind
EP0832972A3 (fr) Expression de peptides utilisés comme exhausteurs de gout

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry