CA2092319A1 - Prolonging expression of polynucleotides introduced into a cell - Google Patents
Prolonging expression of polynucleotides introduced into a cellInfo
- Publication number
- CA2092319A1 CA2092319A1 CA002092319A CA2092319A CA2092319A1 CA 2092319 A1 CA2092319 A1 CA 2092319A1 CA 002092319 A CA002092319 A CA 002092319A CA 2092319 A CA2092319 A CA 2092319A CA 2092319 A1 CA2092319 A1 CA 2092319A1
- Authority
- CA
- Canada
- Prior art keywords
- polynucleotide
- cell
- dna
- hepatocytes
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US588,013 | 1984-03-09 | ||
US58801390A | 1990-09-25 | 1990-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2092319A1 true CA2092319A1 (en) | 1992-03-26 |
Family
ID=24352098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002092319A Abandoned CA2092319A1 (en) | 1990-09-25 | 1991-09-23 | Prolonging expression of polynucleotides introduced into a cell |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0556197A4 (ja) |
JP (1) | JPH06503714A (ja) |
AU (1) | AU8628291A (ja) |
CA (1) | CA2092319A1 (ja) |
WO (1) | WO1992005250A1 (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2082507A1 (en) * | 1990-05-11 | 1991-11-12 | George Y. Wu | Targeted protection from cytotoxins |
ATE199647T1 (de) * | 1991-05-14 | 2001-03-15 | Univ Connecticut | Gerichtete abgabe von genen, die immunogene proteine kodieren |
GB9119762D0 (en) * | 1991-09-16 | 1991-10-30 | Filler Aaron G | Particulate agents for nmt |
PT651805E (pt) * | 1992-07-17 | 2007-02-28 | Dana Farber Cancer Inst Inc | Método de ligação intracelular de moléculas-alvo |
IL106760A (en) * | 1992-08-25 | 1999-12-31 | Miles Inc | Nuclear Acid Protein Hybrid Structure for Transferring Nucleic Acid from External Source to Cell and Target Nucleus |
US5656609A (en) * | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
JPH08508645A (ja) * | 1993-04-05 | 1996-09-17 | ユニバーシティ オブ コネティカット | アンチセンスポリリボヌクレオチドをコードする遺伝子の標的を定めた送達 |
FR2706486B1 (fr) * | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
US5851829A (en) * | 1993-07-16 | 1998-12-22 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
JPH0889278A (ja) * | 1994-09-29 | 1996-04-09 | Ajinomoto Co Inc | 遺伝子導入用修飾蛋白質及びその製法 |
WO1996021036A2 (en) * | 1994-12-30 | 1996-07-11 | Chiron Viagene, Inc. | Nucleic acid condensing agents with reduced immunogenicity |
US5744326A (en) * | 1996-03-11 | 1998-04-28 | The Immune Response Corporation | Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites |
DE69838584T2 (de) | 1997-08-04 | 2008-06-26 | Cell Genesys, Inc., Foster City | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
GB9907366D0 (en) * | 1999-03-30 | 1999-05-26 | Medical Res Council | Method for expressing proteins |
-
1991
- 1991-09-23 WO PCT/US1991/006885 patent/WO1992005250A1/en not_active Application Discontinuation
- 1991-09-23 AU AU86282/91A patent/AU8628291A/en not_active Abandoned
- 1991-09-23 EP EP19910917379 patent/EP0556197A4/en not_active Withdrawn
- 1991-09-23 JP JP3516079A patent/JPH06503714A/ja active Pending
- 1991-09-23 CA CA002092319A patent/CA2092319A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0556197A1 (en) | 1993-08-25 |
JPH06503714A (ja) | 1994-04-28 |
EP0556197A4 (en) | 1994-05-18 |
AU8628291A (en) | 1992-04-15 |
WO1992005250A1 (en) | 1992-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Wu et al. | Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo | |
AU728146B2 (en) | Targeted delivery of genes encoding interferon | |
CA2103371C (en) | Targeted delivery of genes encoding secretory proteins | |
CA2092319A1 (en) | Prolonging expression of polynucleotides introduced into a cell | |
Trubetskoy et al. | Use of N-terminal modified poly (L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells | |
US5656609A (en) | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine | |
Huckett et al. | Evidence for targeted gene transfer by receptor-mediated endocytosis: Stable expression following insulin-directed entry of neo into HepG2 cells | |
EP0532525B1 (de) | Neue protein-polykation-konjugate | |
US6191257B1 (en) | Natural or recombinant DNA binding proteins as carriers for gene transfer or gene therapy | |
WO1992019749A1 (en) | Targeted delivery of genes encoding cell surface receptors | |
WO1997030731A2 (en) | Method of preparing polynucleotide-carrier complexes for delivery to cells | |
AU4673901A (en) | Peptide conjugates for drug delivery | |
EP0577648B1 (de) | Neue protein-polykation-konjugate | |
US5744326A (en) | Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites | |
AU686614B2 (en) | Targeted delivery of genes encoding antisense polyribonucleotides | |
Déas et al. | In vivo-targeted gene delivery using antibody-based nonviral vector | |
US6479464B1 (en) | Compositions and methods for highly efficient transfection | |
AU735667B2 (en) | Targeted delivery of genes encoding secretory proteins | |
WO1998035984A2 (en) | Compositions and methods for highly efficient transfection | |
WO1994028151A1 (en) | Gene therapy for haemophilia | |
US20040009900A1 (en) | Targeted delivery of genes encoding secretory proteins | |
WO1999015687A1 (en) | Multicomponent polynucleotide complex for high efficiency cell transfection |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |