CA2087190A1 - Parathyroid hormone analogues modified at positions - Google Patents

Parathyroid hormone analogues modified at positions

Info

Publication number
CA2087190A1
CA2087190A1 CA002087190A CA2087190A CA2087190A1 CA 2087190 A1 CA2087190 A1 CA 2087190A1 CA 002087190 A CA002087190 A CA 002087190A CA 2087190 A CA2087190 A CA 2087190A CA 2087190 A1 CA2087190 A1 CA 2087190A1
Authority
CA
Canada
Prior art keywords
amino acid
pharmaceutical composition
serine
bpth
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002087190A
Other languages
English (en)
French (fr)
Inventor
Fred E. Cohen
Robert A. Nissenson
Gordon J. Strewler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California, San Diego
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2087190A1 publication Critical patent/CA2087190A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002087190A 1990-07-13 1991-07-15 Parathyroid hormone analogues modified at positions Abandoned CA2087190A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55376090A 1990-07-13 1990-07-13
US553,760 1990-07-13

Publications (1)

Publication Number Publication Date
CA2087190A1 true CA2087190A1 (en) 1992-01-14

Family

ID=24210645

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002087190A Abandoned CA2087190A1 (en) 1990-07-13 1991-07-15 Parathyroid hormone analogues modified at positions

Country Status (5)

Country Link
EP (1) EP0539491A1 (enExample)
JP (1) JPH05509098A (enExample)
AU (1) AU667662B2 (enExample)
CA (1) CA2087190A1 (enExample)
WO (1) WO1992000753A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US6235288B1 (en) 1992-08-26 2001-05-22 The Scripps Research Institute Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus
EP0751961A1 (en) * 1994-03-22 1997-01-08 Research Corporation Technologies, Inc. Eating suppressant peptides
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US6342477B1 (en) 1996-02-01 2002-01-29 Chugai Seiyaku Kabushiki Kaisha Remedies for thrombocytopenia
CN1095681C (zh) * 1996-06-20 2002-12-11 久光制药株式会社 一种用于离子电渗疗法的装置结构
TW505654B (en) * 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
CZ106299A3 (cs) 1996-09-26 1999-08-11 Chugai Seiyaku Kabushiki Kaisha Protilátky proti proteinu příbuznému s lidským parathyroidálním hormonem
CN1817906B (zh) * 1996-09-26 2011-08-10 中外制药株式会社 抗人副甲状腺激素相关蛋白的抗体
WO1998051329A1 (en) 1997-05-15 1998-11-19 Chugai Seiyaku Kabushiki Kaisha Cachexia remedy
CA2332128A1 (en) * 1998-06-26 2000-01-06 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for hypercalcemic crisis
WO2001002011A1 (fr) * 1999-07-02 2001-01-11 Chugai Seiyaku Kabushiki Kaisha REMEDES CONTRE LES MALADIES CAUSEES PAR PTH OU PTHrP
TWI255718B (en) * 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
WO2001002012A1 (fr) * 1999-07-06 2001-01-11 Chugai Seiyaku Kabushiki Kaisha Remedes contre l'hypercalcemie chimio-resistante
WO2001054725A1 (en) * 2000-01-25 2001-08-02 Chugai Seiyaku Kabushiki Kaisha Remedies and preventives for dental diseases
CA2401357A1 (en) * 2000-02-28 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Tissue degradation inhibitor agent
WO2001082968A1 (fr) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation cellulaire
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
US4508828A (en) * 1983-03-21 1985-04-02 Immuno Nuclear Corporation Bioassay of parathyroid hormone
US4771124A (en) * 1987-05-26 1988-09-13 Merck & Co., Inc. Parathyroid hormone antagonists with simplified synthetic methodology
US4968669A (en) * 1988-05-09 1990-11-06 Merck & Co., Inc. Parathyroid hormone antagonists

Also Published As

Publication number Publication date
WO1992000753A1 (en) 1992-01-23
JPH05509098A (ja) 1993-12-16
AU667662B2 (en) 1996-04-04
EP0539491A1 (en) 1993-05-05
EP0539491A4 (enExample) 1994-03-23
AU8299091A (en) 1992-02-04

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Legal Events

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