CA2086679A1 - Receptor directed-toxin conjugates - Google Patents

Receptor directed-toxin conjugates

Info

Publication number
CA2086679A1
CA2086679A1 CA002086679A CA2086679A CA2086679A1 CA 2086679 A1 CA2086679 A1 CA 2086679A1 CA 002086679 A CA002086679 A CA 002086679A CA 2086679 A CA2086679 A CA 2086679A CA 2086679 A1 CA2086679 A1 CA 2086679A1
Authority
CA
Canada
Prior art keywords
toxin
receptor
molecule according
targeted
targeted toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002086679A
Other languages
English (en)
French (fr)
Inventor
Hermanus A. M. Verheul
Ebo S. Bos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2086679A1 publication Critical patent/CA2086679A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002086679A 1990-07-05 1991-06-21 Receptor directed-toxin conjugates Abandoned CA2086679A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90201790.4 1990-07-05
EP90201790 1990-07-05

Publications (1)

Publication Number Publication Date
CA2086679A1 true CA2086679A1 (en) 1992-01-06

Family

ID=8205057

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002086679A Abandoned CA2086679A1 (en) 1990-07-05 1991-06-21 Receptor directed-toxin conjugates

Country Status (7)

Country Link
EP (1) EP0537229A1 (xx)
JP (1) JPH05508634A (xx)
AU (1) AU657910B2 (xx)
CA (1) CA2086679A1 (xx)
IE (1) IE912167A1 (xx)
WO (1) WO1992000762A1 (xx)
ZA (1) ZA914933B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1643692A (en) * 1991-03-07 1992-10-06 Seragen, Inc. Use of cell surface receptor targeted molecules for the treatment of viral diseases
EP0615451B1 (en) * 1992-05-26 2005-12-07 Immunex Corporation Novel cytokine that binds cd30
US5536642A (en) * 1993-09-09 1996-07-16 Barbera-Guillem; Emilio Diagnostic and prognostic methods for solid non-lymphoid tumors and their metastases
EP0831917A2 (en) * 1995-06-07 1998-04-01 Innogenetics N.V. Immunotoxins specific for cd80 and cd86 expressing cells
AU729515B2 (en) 1996-10-17 2001-02-01 Immunomedics Inc. Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
AU2226799A (en) * 1998-01-15 1999-08-02 Center For Molecular Medicine And Immunology Antibody/receptor targeting moiety for enhanced delivery of armed ligand
US6703488B1 (en) 1998-01-15 2004-03-09 Center For Molecular Medicine And Immunology Antibody/receptor targeting moiety for enhanced delivery of armed ligand
CN105899515B (zh) 2013-08-14 2020-01-14 威廉马歇莱思大学 uncialamycin的衍生物、合成方法及其作为抗肿瘤剂的用途
WO2023137443A1 (en) * 2022-01-14 2023-07-20 Regeneron Pharmaceuticals, Inc. Verrucarin a derivatives and antibody drug conjugates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6408586A (en) * 1985-10-03 1987-04-24 Biotechnology Research Partners Limited Novel lipoprotein-based drug-delivery systems
IN165717B (xx) * 1986-08-07 1989-12-23 Battelle Memorial Institute
ZA888978B (en) * 1987-12-04 1990-07-25 Du Pont Immobilized interleukin 2 and interleukin 2 containing a carboxylterminal extension
EP0414816B1 (en) * 1988-05-19 1994-07-27 The Beth Israel Hospital Association Induction of tolerance to a foreign antigen
WO1990000565A1 (en) * 1988-07-05 1990-01-25 Amgen Inc. Interleukin ii analogs
US5149782A (en) * 1988-08-19 1992-09-22 Tanox Biosystems, Inc. Molecular conjugates containing cell membrane-blending agents

Also Published As

Publication number Publication date
JPH05508634A (ja) 1993-12-02
AU8060691A (en) 1992-02-04
ZA914933B (en) 1992-04-29
AU657910B2 (en) 1995-03-30
IE912167A1 (en) 1992-01-15
EP0537229A1 (en) 1993-04-21
WO1992000762A1 (en) 1992-01-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead