CA2084774A1 - Methode de recombinaison homologue dans les cellules animales et vegetales - Google Patents

Methode de recombinaison homologue dans les cellules animales et vegetales

Info

Publication number
CA2084774A1
CA2084774A1 CA 2084774 CA2084774A CA2084774A1 CA 2084774 A1 CA2084774 A1 CA 2084774A1 CA 2084774 CA2084774 CA 2084774 CA 2084774 A CA2084774 A CA 2084774A CA 2084774 A1 CA2084774 A1 CA 2084774A1
Authority
CA
Canada
Prior art keywords
cell
gene sequence
animal
gene
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2084774
Other languages
English (en)
Inventor
Allan Bradley
Ann C. Davis
Paul Hasty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2084774A1 publication Critical patent/CA2084774A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
CA 2084774 1990-06-12 1991-06-07 Methode de recombinaison homologue dans les cellules animales et vegetales Abandoned CA2084774A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US53639790A 1990-06-12 1990-06-12
US536,397 1990-06-12
US53745890A 1990-06-14 1990-06-14
US537,458 1990-06-14
US59769490A 1990-10-17 1990-10-17
US597,694 1990-10-17

Publications (1)

Publication Number Publication Date
CA2084774A1 true CA2084774A1 (fr) 1991-12-13

Family

ID=27415212

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2084774 Abandoned CA2084774A1 (fr) 1990-06-12 1991-06-07 Methode de recombinaison homologue dans les cellules animales et vegetales

Country Status (5)

Country Link
EP (1) EP0535144A4 (fr)
JP (1) JPH05507853A (fr)
AU (1) AU654284B2 (fr)
CA (1) CA2084774A1 (fr)
WO (1) WO1991019796A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048729A (en) 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
DE69133557D1 (de) * 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
AU4115693A (en) 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
EP0656747A4 (fr) * 1992-08-21 1997-05-07 Univ California Composition et procede de modification de sequences d'adn par recombinaison homologue.
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5859310A (en) 1993-06-14 1999-01-12 Basf Aktiengesellschaft Mice transgenic for a tetracycline-controlled transcriptional activator
US5814618A (en) * 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5654168A (en) * 1994-07-01 1997-08-05 Basf Aktiengesellschaft Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units
US5912411A (en) 1993-06-14 1999-06-15 University Of Heidelberg Mice transgenic for a tetracycline-inducible transcriptional activator
US5789156A (en) * 1993-06-14 1998-08-04 Basf Ag Tetracycline-regulated transcriptional inhibitors
US5650298A (en) * 1993-06-14 1997-07-22 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5888981A (en) * 1993-06-14 1999-03-30 Basf Aktiengesellschaft Methods for regulating gene expression
US5589362A (en) * 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
US6004941A (en) * 1993-06-14 1999-12-21 Basf Aktiengesellschaft Methods for regulating gene expression
US5866755A (en) * 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
EP0716690A1 (fr) * 1993-08-30 1996-06-19 Northwestern University Cellules souches pluripotentes d'embryons de rats et leur procede d'obtention et d'utilisation
US5849991A (en) 1994-01-27 1998-12-15 Bresatch Limited Mice homozygous for an inactivated α 1,3-galactosyl transferase gene
SE9402642D0 (sv) * 1994-08-05 1994-08-05 Maria Anvret Gene Therapy
CA2202549C (fr) * 1994-10-14 2003-08-05 Tara Seshadri Animal transgenique comprenant un gene de l'enzyme de conversion d'interleukine-1.beta. a fonction perturbee
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
GB9711015D0 (en) * 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
US6194633B1 (en) 1998-01-26 2001-02-27 University Of Iowa Research Foundation Non-human animal having a functionally disrupted SLP-76 gene
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
GB9921937D0 (en) * 1999-09-17 1999-11-17 Univ Leeds Targeted gens removal
US6465714B2 (en) * 1999-11-05 2002-10-15 Arexis Ab Congenic animal models of non-insulin dependent diabetes mellitus
ATE378403T1 (de) 2000-11-30 2007-11-15 Medarex Inc Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
JP2005508608A (ja) 2001-03-22 2005-04-07 アボット ゲーエムベーハー ウント カンパニー カーゲー 問題遺伝子に対して特異的な抗体を発現するトランスジェニック動物及びその使用
CA2508763C (fr) 2001-05-11 2012-01-24 Kirin Beer Kabushiki Kaisha Souris produisant des anticorps humains et procede de production d'anticorps humains
KR101987351B1 (ko) 2008-09-30 2019-06-10 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 인간 이외의 포유동물
MX2012003816A (es) 2009-10-01 2012-07-04 Toto Ltd Construccion de adn y procedimiento para la generacion de celulas cho recombinantes usando la misma.
EP2553100B1 (fr) 2010-03-31 2017-07-05 Ablexis, LLC Génie génétique sur des animaux non humains pour la production d'anticorps chimériques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000616A1 (fr) * 1988-07-07 1990-01-25 Michael Neumaier Recombinomes
WO1990014092A1 (fr) * 1989-05-18 1990-11-29 Cell Genesys, Inc. Utilisation d'oligonucleotides mono-brins pour la modification axee sur le site de genes mammiferes in vivo

Also Published As

Publication number Publication date
AU654284B2 (en) 1994-11-03
EP0535144A1 (fr) 1993-04-07
AU8182391A (en) 1992-01-07
EP0535144A4 (en) 1993-08-11
JPH05507853A (ja) 1993-11-11
WO1991019796A1 (fr) 1991-12-26

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Legal Events

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FZDE Dead