CA2242382C - Compositions et procedes de mediation de la progression du cycle cellulaire - Google Patents

Compositions et procedes de mediation de la progression du cycle cellulaire Download PDF

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Publication number
CA2242382C
CA2242382C CA002242382A CA2242382A CA2242382C CA 2242382 C CA2242382 C CA 2242382C CA 002242382 A CA002242382 A CA 002242382A CA 2242382 A CA2242382 A CA 2242382A CA 2242382 C CA2242382 C CA 2242382C
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CA
Canada
Prior art keywords
gene
cyclin inhibitor
cells
sequence
cyclin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002242382A
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English (en)
Other versions
CA2242382A1 (fr
Inventor
James M. Roberts
Steven R. Coats
Matthew L. Fero
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Fred Hutchinson Cancer Center
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Fred Hutchinson Cancer Research Center
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Publication date
Priority claimed from US08/588,595 external-priority patent/US5958769A/en
Application filed by Fred Hutchinson Cancer Research Center filed Critical Fred Hutchinson Cancer Research Center
Priority claimed from PCT/US1997/000831 external-priority patent/WO1997026327A1/fr
Publication of CA2242382A1 publication Critical patent/CA2242382A1/fr
Application granted granted Critical
Publication of CA2242382C publication Critical patent/CA2242382C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Organismes non humains hypercellulaires présentant l'expression inactivée de manière fonctionnelle d'un gène inhibiteur de la cycline, notamment p27. Le rythme de développement des organismes non humains est accru de façon à obtenir plus rapidement une taille désirée comparé aux organismes non variants. Les inhibiteurs de la cycline p27 dépendant de la protéine inhibitrice kinase ou des séquences codant la protéine modulent la progression du cycle cellulaire des vertébrés et augmente la proportion des cellules en voie de division par rapport aux cellules stables dans une population de cellules traitées. Lorsque la population des cellules en voie de division augmente, la population cellulaire, c.-à-d. les cellules (souches) progénitrices hématopoïtiques, est utilisée avec plus d'efficacité dans des applications de thérapie génique. L'invention se rapporte également à des animaux et des plantes transgéniques et à des allèles "knockout".
CA002242382A 1996-01-18 1997-01-17 Compositions et procedes de mediation de la progression du cycle cellulaire Expired - Fee Related CA2242382C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/588,595 US5958769A (en) 1996-01-18 1996-01-18 Compositions and methods for mediating cell cycle progression
US08/588,595 1996-01-18
US65656296A 1996-05-31 1996-05-31
US08/656,562 1996-05-31
PCT/US1997/000831 WO1997026327A1 (fr) 1996-01-18 1997-01-17 Compositions et procedes de mediation de la progression du cycle cellulaire

Publications (2)

Publication Number Publication Date
CA2242382A1 CA2242382A1 (fr) 1997-07-24
CA2242382C true CA2242382C (fr) 2007-04-10

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ID=38007242

Family Applications (1)

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CA002242382A Expired - Fee Related CA2242382C (fr) 1996-01-18 1997-01-17 Compositions et procedes de mediation de la progression du cycle cellulaire

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CA (1) CA2242382C (fr)

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Publication number Publication date
CA2242382A1 (fr) 1997-07-24

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