CA2083223A1 - Local delivery of dipyridamole for the treatment of proliferative diseases - Google Patents
Local delivery of dipyridamole for the treatment of proliferative diseasesInfo
- Publication number
- CA2083223A1 CA2083223A1 CA002083223A CA2083223A CA2083223A1 CA 2083223 A1 CA2083223 A1 CA 2083223A1 CA 002083223 A CA002083223 A CA 002083223A CA 2083223 A CA2083223 A CA 2083223A CA 2083223 A1 CA2083223 A1 CA 2083223A1
- Authority
- CA
- Canada
- Prior art keywords
- dipyridamole
- local delivery
- administration
- treatment
- cell proliferation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960002768 dipyridamole Drugs 0.000 title claims abstract description 49
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 title claims abstract description 49
- 238000012384 transportation and delivery Methods 0.000 title claims abstract description 30
- 230000002062 proliferating effect Effects 0.000 title claims abstract description 17
- 201000010099 disease Diseases 0.000 title abstract description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 12
- 230000004663 cell proliferation Effects 0.000 claims abstract description 16
- 239000007943 implant Substances 0.000 claims abstract description 8
- 238000002347 injection Methods 0.000 claims abstract description 5
- 239000007924 injection Substances 0.000 claims abstract description 5
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- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 2
- -1 0.1-10 mg/ml) Substances 0.000 description 1
- JMXNBIDTNISOTA-UHFFFAOYSA-N 12e-Hydroxy-alpha-isospartein Natural products C1N2CCCCC2C2CN3CCCC(O)C3C1C2 JMXNBIDTNISOTA-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- 238000010600 3H thymidine incorporation assay Methods 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 201000000057 Coronary Stenosis Diseases 0.000 description 1
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- 102000004190 Enzymes Human genes 0.000 description 1
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- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- KJKWXYLYSOFPNP-UHFFFAOYSA-N Retamine Natural products OC1CCCN2CC3CC(CC4NCCCC34)C12 KJKWXYLYSOFPNP-UHFFFAOYSA-N 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
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- QGLZXHRNAYXIBU-WEVVVXLNSA-N aldicarb Chemical compound CNC(=O)O\N=C\C(C)(C)SC QGLZXHRNAYXIBU-WEVVVXLNSA-N 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
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- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
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- JMXNBIDTNISOTA-AICCOOGYSA-N retamine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCC[C@H](O)[C@@H]3[C@@H]1C2 JMXNBIDTNISOTA-AICCOOGYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/795,434 US5270047A (en) | 1991-11-21 | 1991-11-21 | Local delivery of dipyridamole for the treatment of proliferative diseases |
| US07/795,434 | 1991-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2083223A1 true CA2083223A1 (en) | 1993-05-22 |
Family
ID=25165502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002083223A Abandoned CA2083223A1 (en) | 1991-11-21 | 1992-11-18 | Local delivery of dipyridamole for the treatment of proliferative diseases |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5270047A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0543653A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH05201862A (cg-RX-API-DMAC10.html) |
| KR (1) | KR930009607A (cg-RX-API-DMAC10.html) |
| AU (1) | AU661067B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2083223A1 (cg-RX-API-DMAC10.html) |
| HU (1) | HU212422B (cg-RX-API-DMAC10.html) |
| MX (1) | MX9206610A (cg-RX-API-DMAC10.html) |
| NO (1) | NO924461L (cg-RX-API-DMAC10.html) |
| RU (1) | RU2084224C1 (cg-RX-API-DMAC10.html) |
| TW (1) | TW252917B (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA928832B (cg-RX-API-DMAC10.html) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5770609A (en) * | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6395494B1 (en) | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| JPH08506112A (ja) * | 1993-01-28 | 1996-07-02 | ネオルックス コーポレイション | 血管平滑筋細胞の治療用インヒビター |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| WO1994026303A1 (en) * | 1993-05-13 | 1994-11-24 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
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-
1991
- 1991-11-21 US US07/795,434 patent/US5270047A/en not_active Expired - Fee Related
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1992
- 1992-11-16 ZA ZA928832A patent/ZA928832B/xx unknown
- 1992-11-16 RU RU9292004406A patent/RU2084224C1/ru active
- 1992-11-17 MX MX9206610A patent/MX9206610A/es not_active Application Discontinuation
- 1992-11-18 KR KR1019920021672A patent/KR930009607A/ko not_active Withdrawn
- 1992-11-18 TW TW081109231A patent/TW252917B/zh active
- 1992-11-18 JP JP4308615A patent/JPH05201862A/ja not_active Withdrawn
- 1992-11-18 AU AU28454/92A patent/AU661067B2/en not_active Ceased
- 1992-11-18 CA CA002083223A patent/CA2083223A1/en not_active Abandoned
- 1992-11-19 EP EP92310577A patent/EP0543653A1/en not_active Withdrawn
- 1992-11-19 NO NO92924461A patent/NO924461L/no unknown
- 1992-11-19 HU HU9203626A patent/HU212422B/hu not_active IP Right Cessation
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1993
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| AU661067B2 (en) | 1995-07-13 |
| RU2084224C1 (ru) | 1997-07-20 |
| EP0543653A1 (en) | 1993-05-26 |
| AU2845492A (en) | 1993-05-27 |
| NO924461D0 (no) | 1992-11-19 |
| KR930009607A (ko) | 1993-06-21 |
| HU212422B (en) | 1996-06-28 |
| JPH05201862A (ja) | 1993-08-10 |
| US5270047A (en) | 1993-12-14 |
| US5314688A (en) | 1994-05-24 |
| NO924461L (no) | 1993-05-24 |
| ZA928832B (en) | 1994-05-16 |
| MX9206610A (es) | 1993-05-01 |
| TW252917B (cg-RX-API-DMAC10.html) | 1995-08-01 |
| HUT70034A (en) | 1995-09-28 |
| HU9203626D0 (en) | 1993-01-28 |
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