CA2077213A1 - Bicyclic carboxylic acid derivatives - Google Patents

Bicyclic carboxylic acid derivatives

Info

Publication number
CA2077213A1
CA2077213A1 CA002077213A CA2077213A CA2077213A1 CA 2077213 A1 CA2077213 A1 CA 2077213A1 CA 002077213 A CA002077213 A CA 002077213A CA 2077213 A CA2077213 A CA 2077213A CA 2077213 A1 CA2077213 A1 CA 2077213A1
Authority
CA
Canada
Prior art keywords
oxy
compound
propyl
formula
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002077213A
Other languages
English (en)
French (fr)
Inventor
Ferdinand Kwo-Chen Lee
Keith Alan Yagaloff
Noal Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2077213A1 publication Critical patent/CA2077213A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
CA002077213A 1991-09-10 1992-08-31 Bicyclic carboxylic acid derivatives Abandoned CA2077213A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75710091A 1991-09-10 1991-09-10
US757,100 1991-09-10
US898,852 1992-06-15
US07/898,852 US5273999A (en) 1991-09-10 1992-06-15 Carboxylic acid leukotriene B4 antagonists

Publications (1)

Publication Number Publication Date
CA2077213A1 true CA2077213A1 (en) 1993-03-11

Family

ID=27116327

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002077213A Abandoned CA2077213A1 (en) 1991-09-10 1992-08-31 Bicyclic carboxylic acid derivatives

Country Status (15)

Country Link
US (2) US5273999A (OSRAM)
EP (1) EP0531823A1 (OSRAM)
JP (1) JPH05201915A (OSRAM)
KR (1) KR930005998A (OSRAM)
CN (1) CN1071423A (OSRAM)
AU (1) AU655057B2 (OSRAM)
CA (1) CA2077213A1 (OSRAM)
CZ (1) CZ265492A3 (OSRAM)
FI (1) FI924048A7 (OSRAM)
HU (1) HUT66238A (OSRAM)
IL (1) IL103058A0 (OSRAM)
NO (1) NO923508L (OSRAM)
NZ (1) NZ244218A (OSRAM)
RU (1) RU2067973C1 (OSRAM)
TW (1) TW218013B (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
US5753702A (en) * 1996-05-22 1998-05-19 University Of Vermont Arachidonic acid metabolite, 16-hete
US6004808A (en) * 1996-06-21 1999-12-21 Aurora Biosciences Corporation Promiscuous G-protein compositions and their use
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
WO1999059964A1 (en) 1998-05-15 1999-11-25 University Of Vermont Novel analogs of 16-hydroxyeicosatetraenoic acid
BR9915090A (pt) * 1998-11-05 2001-10-30 Toyama Chemical Co Ltd Composto ou um sal do mesmo, peptìdeo ou um saldo mesmo, derivado de benzeno ou um sal domesmo, método para inibir ap-1, agente paraprevenir e tratar uma doença na qual participeuma sobre-expressão de ap-1 e uma doençaautoimune, e, inibidor de ap-1
US6019992A (en) * 1998-12-04 2000-02-01 Chesebrough-Pond's Usa Co. Cosmetic skin care compositions containing 4-chromanone
FR2791344B1 (fr) * 1999-03-25 2002-02-15 Adir Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RU2183126C2 (ru) * 2000-06-26 2002-06-10 Государственное унитарное предприятие "Иммунопрепарат" Средство, нормализующее функциональную активность спинного мозга, и способ его получения
RU2224528C2 (ru) * 2001-07-24 2004-02-27 Брянский государственный университет им. акад. И.Г. Петровского Способ получения биологически активных пептидов каудальной нейросекреторной системы (кнсс) позвоночных
JP4554926B2 (ja) 2001-11-16 2010-09-29 富山化学工業株式会社 新規なベンゾフェノン誘導体またはその塩
DE60322075D1 (de) * 2002-07-30 2008-08-21 Merck & Co Inc Ppar alpha selektive verbindungen zur behandlung von dyslipidämie und anderen lipidstörungen
DE60332738D1 (de) * 2002-07-30 2010-07-08 Merck Sharp & Dohme Ppar alpha selektive verbindungen zur behandlung von dyslipidämie und anderen lipidstörungen
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
CN102741662B (zh) * 2010-01-13 2016-09-14 Qsc公司 光控电动控制设备
CN105431405B (zh) * 2013-03-14 2018-06-01 澳门大学 分离自益智仁的新抗神经变性天然化合物及其全合成
CN105418576B (zh) * 2015-11-16 2018-03-13 北京新沿线医药科技发展有限公司 一种伪麻黄碱类衍生物及其抗过敏应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776944A (en) * 1971-09-16 1973-12-04 Warner Lambert Co Tetraloneoxy acetic acids and esters thereof
EP0079637B1 (en) * 1981-11-12 1987-01-28 FISONS plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4992576A (en) * 1987-01-12 1991-02-12 Eli Lilly And Company Intermediates for leukotriene antagonists
FR2615515B1 (fr) * 1987-05-22 1989-06-30 Adir Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US5124350A (en) * 1990-06-28 1992-06-23 G. D. Searle & Co. Leukotriene b4 antagonists

Also Published As

Publication number Publication date
US5434186A (en) 1995-07-18
FI924048L (fi) 1993-03-11
US5273999A (en) 1993-12-28
HU9202817D0 (en) 1992-11-30
FI924048A0 (fi) 1992-09-10
AU2219192A (en) 1993-03-11
JPH05201915A (ja) 1993-08-10
IL103058A0 (en) 1993-02-21
RU2067973C1 (ru) 1996-10-20
EP0531823A1 (en) 1993-03-17
TW218013B (OSRAM) 1993-12-21
NO923508L (no) 1993-03-11
AU655057B2 (en) 1994-12-01
CZ265492A3 (en) 1993-03-17
NZ244218A (en) 1995-07-26
FI924048A7 (fi) 1993-03-11
CN1071423A (zh) 1993-04-28
NO923508D0 (no) 1992-09-09
KR930005998A (ko) 1993-04-20
HUT66238A (en) 1994-10-28

Similar Documents

Publication Publication Date Title
CA2077213A1 (en) Bicyclic carboxylic acid derivatives
US4517200A (en) Method for treating allergic reactions with forskolin
US5401746A (en) Substituted pyridines heptenoic acid derivatives, useful for treating arterioscleros, lipopotaemia and the like
EP1354878B1 (en) Tetrahydroquinoline derivatives having selective activity for retinoid x receptors
JP2954954B2 (ja) 置換された２―ピリドン及びピリド―２―チオン、それらの製造方法、及び医薬におけるそれらの使用
US4752613A (en) Sulphonamidothienylcarboxylic acid compounds
CA2046734A1 (en) Substituted pyrrolo-pyridines pharmaceuticals
US5502216A (en) Lignan analogues, methods of preparation thereof and anti-hyperlipemic agents
US4151357A (en) Polyprenyl piperazines
US4895946A (en) Process for the preparation of fused pyridine compounds
US4377702A (en) Acetic acid derivatives
HU202502B (en) Process for producing new 3,5-dihydroxi-carboxylic acids and their derivatives as well as pharmaceutical preparatives containing these compounds
US4829081A (en) Analogs of mevalonolactone and derivatives thereof
US4205170A (en) Propionic acid derivatives
US4927851A (en) Analogs of mevalonolactone and derivatives thereof
US4576949A (en) Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein
US5075311A (en) Hmg-coa reductase inhibiting substituted pryido (2,3-d) pyrimidines
EP0339358B1 (en) Pyrazolopyridine type mevalonolactones
US4757078A (en) Cyclic aryl hydroxamic acids, derivatives thereof and method of use as anti-allergy agents
US4199519A (en) Higher polyalkenyl fatty acids and esters
US5019573A (en) Substituted dibenzofurans and methods of using same
GB2209336A (en) Germinally substituted cyclic ether carboxylic acids
US5138090A (en) Substituted biphenyls
US4782082A (en) Method for treating allergic reactions with Forskolin
US4322543A (en) 4,5-Unsaturated prostanoic acid derivatives

Legal Events

Date Code Title Description
FZDE Discontinued