CA2073063A1 - Derives nucleosidiques - Google Patents

Derives nucleosidiques

Info

Publication number
CA2073063A1
CA2073063A1 CA002073063A CA2073063A CA2073063A1 CA 2073063 A1 CA2073063 A1 CA 2073063A1 CA 002073063 A CA002073063 A CA 002073063A CA 2073063 A CA2073063 A CA 2073063A CA 2073063 A1 CA2073063 A1 CA 2073063A1
Authority
CA
Canada
Prior art keywords
mmol
added
dideoxy
group
pent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002073063A
Other languages
English (en)
Inventor
Jo Klaveness
Kjell Undheim
Frode Rise
Jostein Hatlelid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898925039A external-priority patent/GB8925039D0/en
Priority claimed from GB898925037A external-priority patent/GB8925037D0/en
Application filed by Individual filed Critical Individual
Publication of CA2073063A1 publication Critical patent/CA2073063A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002073063A 1989-11-06 1990-11-06 Derives nucleosidiques Abandoned CA2073063A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8925039.5 1989-11-06
GB8925037.7 1989-11-06
GB898925039A GB8925039D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives
GB898925037A GB8925037D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives

Publications (1)

Publication Number Publication Date
CA2073063A1 true CA2073063A1 (fr) 1991-05-07

Family

ID=26296164

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002073063A Abandoned CA2073063A1 (fr) 1989-11-06 1990-11-06 Derives nucleosidiques

Country Status (7)

Country Link
EP (1) EP0500610A1 (fr)
JP (1) JPH05501404A (fr)
AU (1) AU636678B2 (fr)
CA (1) CA2073063A1 (fr)
FI (1) FI922014A (fr)
OA (1) OA09697A (fr)
WO (1) WO1991006554A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5289904A (en) * 1992-08-28 1994-03-01 Harrison Everett W Sound dampener for disk brakes
JPH0692987A (ja) * 1992-09-17 1994-04-05 Tanabe Seiyaku Co Ltd ウリジン誘導体およびその製法
AU6686394A (en) * 1993-05-12 1994-12-12 Rhone-Poulenc Chemicals Limited Preparation of fluoro-nucleosides and intermediates for use therein
GB9309795D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Preparation of flouro-compounds
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US7115584B2 (en) 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
JP5765536B2 (ja) 2010-02-15 2015-08-19 日産化学工業株式会社 β−グリコシド化合物の製造方法
US9212174B2 (en) 2010-02-15 2015-12-15 Nissan Chemical Industries, Ltd. Certain β-dihydrofuran derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
KR960001623B1 (ko) * 1986-07-21 1996-02-03 다이낑 고오교 가부시끼가이샤 폴리테트라플루오로에틸렌함유피복조성물과그용도
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
EP0286825A3 (fr) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Utilisation du 3'-fluro-3'-deoxythymidine pour fabriquer un médicament pour le traitement des infections virales
DE3850571T2 (de) * 1987-03-24 1994-10-27 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
EP0294113A1 (fr) * 1987-05-29 1988-12-07 The Wellcome Foundation Limited Nucléosides thérapeutiques
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
ZA891076B (en) * 1988-02-16 1990-10-31 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoronucleosides
EP0355031A3 (fr) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
WO1991015498A2 (fr) * 1990-04-04 1991-10-17 Nycomed Imaging As Derives nucleosidiques

Also Published As

Publication number Publication date
OA09697A (en) 1993-08-30
FI922014A0 (fi) 1992-05-05
WO1991006554A1 (fr) 1991-05-16
AU636678B2 (en) 1993-05-06
EP0500610A1 (fr) 1992-09-02
JPH05501404A (ja) 1993-03-18
FI922014A (fi) 1992-05-05
AU6619290A (en) 1991-05-31

Similar Documents

Publication Publication Date Title
EP0342203B1 (fr) Derives d'oxyde de 2',3' didesoxyribofuranne
US5668113A (en) Method of using 1,5-anhydrohexitol nucleoside analogues to treat viral infections
US6130326A (en) Monocyclic L-Nucleosides, analogs and uses thereof
US6573247B1 (en) Anti-viral pyrimidine nucleoside analogues
AU780879B2 (en) Anti-viral pyrimidine nucleoside analogues
CA2079796A1 (fr) Derives de nucleosides
EP0296573B1 (fr) Nucléosides, leur préparation et compositions pharmaceutiques
AU636678B2 (en) Nucleoside derivatives
AU617543B2 (en) Nucleoside derivatives
AU5691094A (en) Dihydropyrimidine nucleosides with antiviral properties
AU7695991A (en) Carbo-nucleoside derivatives
AU626600B2 (en) Nucleoside derivatives
US5644043A (en) 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates
USRE33887E (en) Anti-retroviral compounds
JPH1087687A (ja) ５−置換−１−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）ウラシル
MXPA99003434A (en) Monocyclic l-nucleosides, analogs and uses thereof
MXPA99009965A (en) Anti-viral pyrimidine nucleoside analogues

Legal Events

Date Code Title Description
FZDE Dead