WO1991015498A2 - Derives nucleosidiques - Google Patents

Derives nucleosidiques Download PDF

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Publication number
WO1991015498A2
WO1991015498A2 PCT/EP1991/000639 EP9100639W WO9115498A2 WO 1991015498 A2 WO1991015498 A2 WO 1991015498A2 EP 9100639 W EP9100639 W EP 9100639W WO 9115498 A2 WO9115498 A2 WO 9115498A2
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WO
WIPO (PCT)
Prior art keywords
group
formula
groups
compounds
fluoro
Prior art date
Application number
PCT/EP1991/000639
Other languages
English (en)
Other versions
WO1991015498A3 (fr
Inventor
Jo Klaveness
Kjell Undheim
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1991015498(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909007566A external-priority patent/GB9007566D0/en
Priority claimed from GB909007650A external-priority patent/GB9007650D0/en
Priority claimed from GB909007651A external-priority patent/GB9007651D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Priority to JP91506841A priority Critical patent/JPH05505815A/ja
Priority to CA002079796A priority patent/CA2079796A1/fr
Publication of WO1991015498A2 publication Critical patent/WO1991015498A2/fr
Publication of WO1991015498A3 publication Critical patent/WO1991015498A3/fr
Priority to NO92923849A priority patent/NO923849L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Composés nucléosidiques répondant à la formule (I): Y1O-G-X dans laquelle Y1 est un atome d'hydrogène ou un groupe acyle ou acyloxyméthyle; G est le résidu de la moitié glycone du nucléoside; et X est une base de purine ou de pyrimidine ou un dérivé ester, amide ou acyloxyalkyle de cette base. Les composés présentent une activité antivirale.
PCT/EP1991/000639 1990-04-04 1991-04-04 Derives nucleosidiques WO1991015498A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP91506841A JPH05505815A (ja) 1990-04-04 1991-04-04 ヌクレオシド誘導体
CA002079796A CA2079796A1 (fr) 1990-04-04 1991-04-04 Derives de nucleosides
NO92923849A NO923849L (no) 1990-04-04 1992-10-02 Nukleosid-derivater

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9007650.6 1990-04-04
GB909007566A GB9007566D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB9007566.4 1990-04-04
GB909007650A GB9007650D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB909007651A GB9007651D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB9007651.4 1990-04-04

Publications (2)

Publication Number Publication Date
WO1991015498A2 true WO1991015498A2 (fr) 1991-10-17
WO1991015498A3 WO1991015498A3 (fr) 1992-06-11

Family

ID=27265029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000639 WO1991015498A2 (fr) 1990-04-04 1991-04-04 Derives nucleosidiques

Country Status (6)

Country Link
EP (1) EP0523110A1 (fr)
JP (1) JPH05505815A (fr)
AU (1) AU7558491A (fr)
CA (1) CA2079796A1 (fr)
OA (1) OA09677A (fr)
WO (1) WO1991015498A2 (fr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0588317A1 (fr) * 1992-09-17 1994-03-23 Tanabe Seiyaku Co., Ltd. Dérivé d'uridine et son procédé de préparation
JPH06157570A (ja) * 1992-06-22 1994-06-03 Eli Lilly & Co 立体選択的グリコシル化法
US5430026A (en) * 1992-06-22 1995-07-04 Eli Lilly And Company 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic derivatives,pharmaceutical compositions, and synthetic precursors
EP1567169A2 (fr) * 2002-11-04 2005-08-31 Xenoport, Inc. Promedicaments de gemcitabine, leurs compositions pharmaceutiques et leurs utilisations
WO2006111058A1 (fr) * 2005-04-18 2006-10-26 Chengdu Zhengkai Biotech Co. Ltd. N4-(oxycarbonyle substitue)-2',2'-difluoro-2'-desoxycytidines et leurs utilisations
US7678830B2 (en) 2002-01-15 2010-03-16 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US7795305B2 (en) 2000-11-28 2010-09-14 Board Of Regents, The University Of Texas System CDDO-compounds and combination therapies thereof
US7863327B2 (en) 1998-06-19 2011-01-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7915402B2 (en) 2008-04-18 2011-03-29 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US7943778B2 (en) 2008-04-18 2011-05-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US8129429B2 (en) 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8258329B2 (en) 2008-04-18 2012-09-04 Reata Pharmaceuticals, Inc. Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2013151774A1 (fr) 2012-04-04 2013-10-10 Halozyme, Inc. Polythérapie par un agent anti-hyaluronane et un taxane ciblant une tumeur
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US9205113B2 (en) 2012-05-08 2015-12-08 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
WO2016078160A1 (fr) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Dérivé de cytidine et application de celui-ci
WO2016078397A1 (fr) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Nouveau type de dérivé de cytidine et application de celui-ci
WO2019222435A1 (fr) 2018-05-16 2019-11-21 Halozyme, Inc. Procédés de sélection de sujets pour une polythérapie anticancéreuse avec un ph20 soluble conjugué à un polymère
WO2020216646A1 (fr) * 2019-04-24 2020-10-29 Aenorasis Commercial Company of Pharmaceutical and Medical Products and Machines Societe Anonyme Dérivés de cytidine et procédés de formation de dérivés de cytidine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0500610A1 (fr) * 1989-11-06 1992-09-02 Nycomed Imaging As Derives de nucleosides
JPH11217396A (ja) * 1998-01-30 1999-08-10 Ajinomoto Co Inc ヌクレオシド誘導体の製造方法

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
EP0042596A1 (fr) * 1980-06-23 1981-12-30 The Regents Of The University Of Minnesota Dérivés d'adénosine, leur préparation et compositions pharmaceutiques les contenant
EP0056265A2 (fr) * 1981-01-09 1982-07-21 Dr. Thilo & Co. GmbH Pyrimidinenucléosides estérifiés en position 5' ayant une activité antivirale, méthode pour leur préparation et les médicaments les contenant
EP0104857A1 (fr) * 1982-09-28 1984-04-04 Beecham Group Plc Dérivés de la déoxyuridine, leurs méthodes de préparation et leur emploi en médecine
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
EP0151189A1 (fr) * 1983-07-20 1985-08-14 Teijin Limited Agent antineoplastique
EP0217580A2 (fr) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Nucléosides thérapeutiques
EP0219829A2 (fr) * 1985-10-18 1987-04-29 Sloan-Kettering Institute For Cancer Research Nucléosides 2-fluoro-arabinofuranosyl purine
EP0260852A2 (fr) * 1986-09-08 1988-03-23 The Wellcome Foundation Limited Analogues aux nucléosides
WO1988007532A1 (fr) * 1987-03-24 1988-10-06 Nycomed A.S. Derives d'oxyde de 2',3' didesoxyribofuranne
EP0329348A2 (fr) * 1988-02-16 1989-08-23 Eli Lilly And Company Nucléosides-2',3'-didéoxy-2',2'-difluoro
EP0340778A2 (fr) * 1988-05-06 1989-11-08 Bristol-Myers Squibb Company Prodrogues de 2',3'-didéshydro-2',3'-didésoxynucléosides
EP0341704A2 (fr) * 1988-05-12 1989-11-15 F. Hoffmann-La Roche Ag Procédé pour la préparation de 2',3'-didéoxycytidines
EP0346108A2 (fr) * 1988-06-09 1989-12-13 The Wellcome Foundation Limited Nucléosides anti-infectieux
EP0355031A2 (fr) * 1988-08-17 1990-02-21 MATTHES, Eckart, Dr. Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant
EP0362967A1 (fr) * 1988-10-05 1990-04-11 Nycomed Imaging As Dérivés de nucléosides
EP0366171A1 (fr) * 1988-10-05 1990-05-02 Nycomed As Dérivés de nucléosides
EP0417999A1 (fr) * 1989-09-11 1991-03-20 The Wellcome Foundation Limited Composés antiviraux

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
EP0042596A1 (fr) * 1980-06-23 1981-12-30 The Regents Of The University Of Minnesota Dérivés d'adénosine, leur préparation et compositions pharmaceutiques les contenant
EP0056265A2 (fr) * 1981-01-09 1982-07-21 Dr. Thilo & Co. GmbH Pyrimidinenucléosides estérifiés en position 5' ayant une activité antivirale, méthode pour leur préparation et les médicaments les contenant
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
EP0104857A1 (fr) * 1982-09-28 1984-04-04 Beecham Group Plc Dérivés de la déoxyuridine, leurs méthodes de préparation et leur emploi en médecine
EP0151189A1 (fr) * 1983-07-20 1985-08-14 Teijin Limited Agent antineoplastique
EP0217580A2 (fr) * 1985-09-17 1987-04-08 The Wellcome Foundation Limited Nucléosides thérapeutiques
EP0219829A2 (fr) * 1985-10-18 1987-04-29 Sloan-Kettering Institute For Cancer Research Nucléosides 2-fluoro-arabinofuranosyl purine
EP0260852A2 (fr) * 1986-09-08 1988-03-23 The Wellcome Foundation Limited Analogues aux nucléosides
WO1988007532A1 (fr) * 1987-03-24 1988-10-06 Nycomed A.S. Derives d'oxyde de 2',3' didesoxyribofuranne
EP0329348A2 (fr) * 1988-02-16 1989-08-23 Eli Lilly And Company Nucléosides-2',3'-didéoxy-2',2'-difluoro
EP0340778A2 (fr) * 1988-05-06 1989-11-08 Bristol-Myers Squibb Company Prodrogues de 2',3'-didéshydro-2',3'-didésoxynucléosides
EP0341704A2 (fr) * 1988-05-12 1989-11-15 F. Hoffmann-La Roche Ag Procédé pour la préparation de 2',3'-didéoxycytidines
EP0346108A2 (fr) * 1988-06-09 1989-12-13 The Wellcome Foundation Limited Nucléosides anti-infectieux
EP0355031A2 (fr) * 1988-08-17 1990-02-21 MATTHES, Eckart, Dr. Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant
EP0362967A1 (fr) * 1988-10-05 1990-04-11 Nycomed Imaging As Dérivés de nucléosides
EP0366171A1 (fr) * 1988-10-05 1990-05-02 Nycomed As Dérivés de nucléosides
EP0417999A1 (fr) * 1989-09-11 1991-03-20 The Wellcome Foundation Limited Composés antiviraux

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06157570A (ja) * 1992-06-22 1994-06-03 Eli Lilly & Co 立体選択的グリコシル化法
US5430026A (en) * 1992-06-22 1995-07-04 Eli Lilly And Company 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic derivatives,pharmaceutical compositions, and synthetic precursors
EP0588317A1 (fr) * 1992-09-17 1994-03-23 Tanabe Seiyaku Co., Ltd. Dérivé d'uridine et son procédé de préparation
US7863327B2 (en) 1998-06-19 2011-01-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US8034955B2 (en) 1998-06-19 2011-10-11 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US8586775B2 (en) 1998-06-19 2013-11-19 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7795305B2 (en) 2000-11-28 2010-09-14 Board Of Regents, The University Of Texas System CDDO-compounds and combination therapies thereof
US7678830B2 (en) 2002-01-15 2010-03-16 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US8067465B2 (en) 2002-01-15 2011-11-29 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
EP1567169A2 (fr) * 2002-11-04 2005-08-31 Xenoport, Inc. Promedicaments de gemcitabine, leurs compositions pharmaceutiques et leurs utilisations
US7803785B2 (en) 2002-11-04 2010-09-28 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
EP1567169A4 (fr) * 2002-11-04 2009-10-21 Xenoport Inc Promedicaments de gemcitabine, leurs compositions pharmaceutiques et leurs utilisations
US7608602B2 (en) 2002-11-04 2009-10-27 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
WO2006111058A1 (fr) * 2005-04-18 2006-10-26 Chengdu Zhengkai Biotech Co. Ltd. N4-(oxycarbonyle substitue)-2',2'-difluoro-2'-desoxycytidines et leurs utilisations
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8067394B2 (en) 2006-11-17 2011-11-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8129429B2 (en) 2008-01-11 2012-03-06 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8455544B2 (en) 2008-01-11 2013-06-04 Reata Pharmaecuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
US8440820B2 (en) 2008-04-18 2013-05-14 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US7943778B2 (en) 2008-04-18 2011-05-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US8338618B2 (en) 2008-04-18 2012-12-25 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8394967B2 (en) 2008-04-18 2013-03-12 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
US8124656B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US8440854B2 (en) 2008-04-18 2013-05-14 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino acid and other modifications at C-17
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US10093614B2 (en) 2008-04-18 2018-10-09 Reata Pharmaceuticals, Inc. Antioxidant Inflamation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9796668B2 (en) 2008-04-18 2017-10-24 Reata Pharmaceuticals, Inc. Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use
US7915402B2 (en) 2008-04-18 2011-03-29 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
US11919838B2 (en) 2008-04-18 2024-03-05 Reata Pharmaceuticals Holdings, LLC Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US11091430B2 (en) 2008-04-18 2021-08-17 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
US10556858B2 (en) 2008-04-18 2020-02-11 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US9670147B2 (en) 2008-04-18 2017-06-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
US8258329B2 (en) 2008-04-18 2012-09-04 Reata Pharmaceuticals, Inc. Dehydroandrosterone analogs including an anti-inflammatory pharmacore and methods of use
US10137104B2 (en) 2012-04-04 2018-11-27 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
WO2013151774A1 (fr) 2012-04-04 2013-10-10 Halozyme, Inc. Polythérapie par un agent anti-hyaluronane et un taxane ciblant une tumeur
US9539287B2 (en) 2012-05-08 2017-01-10 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9205113B2 (en) 2012-05-08 2015-12-08 Trustees Of Dartmouth College Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
EP3210992A4 (fr) * 2014-11-17 2017-11-08 Changzhou Fangyuan Pharmaceutical Co., Ltd. Nouveau type de dérivé de cytidine et application de celui-ci
CN106146583A (zh) * 2014-11-17 2016-11-23 常州方圆制药有限公司 新型胞苷衍生物及其应用
US10174067B2 (en) 2014-11-17 2019-01-08 Changzhou Fangyuan Pharmaceutical Co., Ltd Type of cytidine derivative and application thereof
AU2015349390B2 (en) * 2014-11-17 2019-03-07 Changzhou Fangyuan Pharmaceutical Co., Ltd New type of cytidine derivative and application thereof
RU2684402C2 (ru) * 2014-11-17 2019-04-09 Чанчжоу Фанюань Фармасьютикал Ко., Лтд Новый тип производного цитидина и его применение
WO2016078397A1 (fr) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Nouveau type de dérivé de cytidine et application de celui-ci
WO2016078160A1 (fr) * 2014-11-17 2016-05-26 常州方圆制药有限公司 Dérivé de cytidine et application de celui-ci
WO2019222435A1 (fr) 2018-05-16 2019-11-21 Halozyme, Inc. Procédés de sélection de sujets pour une polythérapie anticancéreuse avec un ph20 soluble conjugué à un polymère
WO2020216646A1 (fr) * 2019-04-24 2020-10-29 Aenorasis Commercial Company of Pharmaceutical and Medical Products and Machines Societe Anonyme Dérivés de cytidine et procédés de formation de dérivés de cytidine
GR20190100181A (el) * 2019-04-24 2020-11-16 ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης

Also Published As

Publication number Publication date
WO1991015498A3 (fr) 1992-06-11
AU7558491A (en) 1991-10-30
OA09677A (en) 1993-05-15
CA2079796A1 (fr) 1991-10-05
JPH05505815A (ja) 1993-08-26
EP0523110A1 (fr) 1993-01-20

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