WO1991015498A3 - Derives nucleosidiques - Google Patents
Derives nucleosidiques Download PDFInfo
- Publication number
- WO1991015498A3 WO1991015498A3 PCT/EP1991/000639 EP9100639W WO9115498A3 WO 1991015498 A3 WO1991015498 A3 WO 1991015498A3 EP 9100639 W EP9100639 W EP 9100639W WO 9115498 A3 WO9115498 A3 WO 9115498A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleoside
- nucleoside derivatives
- compounds
- purine
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP91506841A JPH05505815A (ja) | 1990-04-04 | 1991-04-04 | ヌクレオシド誘導体 |
CA002079796A CA2079796A1 (fr) | 1990-04-04 | 1991-04-04 | Derives de nucleosides |
NO92923849A NO923849L (no) | 1990-04-04 | 1992-10-02 | Nukleosid-derivater |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9007650.6 | 1990-04-04 | ||
GB909007566A GB9007566D0 (en) | 1990-04-04 | 1990-04-04 | Nucleoside derivatives |
GB9007566.4 | 1990-04-04 | ||
GB909007650A GB9007650D0 (en) | 1990-04-04 | 1990-04-04 | Nucleoside derivatives |
GB909007651A GB9007651D0 (en) | 1990-04-04 | 1990-04-04 | Nucleoside derivatives |
GB9007651.4 | 1990-04-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991015498A2 WO1991015498A2 (fr) | 1991-10-17 |
WO1991015498A3 true WO1991015498A3 (fr) | 1992-06-11 |
Family
ID=27265029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1991/000639 WO1991015498A2 (fr) | 1990-04-04 | 1991-04-04 | Derives nucleosidiques |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0523110A1 (fr) |
JP (1) | JPH05505815A (fr) |
AU (1) | AU7558491A (fr) |
CA (1) | CA2079796A1 (fr) |
OA (1) | OA09677A (fr) |
WO (1) | WO1991015498A2 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE45288E1 (en) | 2008-04-18 | 2014-12-09 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring |
US9102681B2 (en) | 2008-04-18 | 2015-08-11 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
US9233998B2 (en) | 2008-04-18 | 2016-01-12 | Reata Pharmaceuticals, Inc. | Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use |
US9249089B2 (en) | 2008-04-18 | 2016-02-02 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0500610A1 (fr) * | 1989-11-06 | 1992-09-02 | Nycomed Imaging As | Derives de nucleosides |
UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
YU43193A (sh) * | 1992-06-22 | 1997-01-08 | Eli Lilly And Company | 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi |
JPH0692987A (ja) * | 1992-09-17 | 1994-04-05 | Tanabe Seiyaku Co Ltd | ウリジン誘導体およびその製法 |
JPH11217396A (ja) * | 1998-01-30 | 1999-08-10 | Ajinomoto Co Inc | ヌクレオシド誘導体の製造方法 |
US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
EP1567169A4 (fr) | 2002-11-04 | 2009-10-21 | Xenoport Inc | Promedicaments de gemcitabine, leurs compositions pharmaceutiques et leurs utilisations |
CN1693309A (zh) * | 2005-04-18 | 2005-11-09 | 成都正开生物科技发展有限公司 | N4-(取代的氧羰基)-2′,2′-二氟-2′-脱氧胞苷衍生物及其应用 |
US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
WO2008064132A2 (fr) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Triterpénoïdes synthétiques et bis-énones tricycliques pour une utilisation dans la stimulation de croissance osseuse et cartilagineuse |
US7714012B2 (en) | 2006-11-17 | 2010-05-11 | Trustees Of Dartmouth University | Synthesis and biological activities of new tricyclic-bis-enones (TBEs) |
MX356760B (es) | 2008-01-11 | 2018-06-12 | Dartmouth College | Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad. |
US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
CA2869460C (fr) | 2012-04-04 | 2018-05-15 | Halozyme, Inc. | Polytherapie par un agent anti-hyaluronane et un taxane ciblant une tumeur |
US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
WO2016078397A1 (fr) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | Nouveau type de dérivé de cytidine et application de celui-ci |
WO2016078160A1 (fr) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | Dérivé de cytidine et application de celui-ci |
WO2019222435A1 (fr) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Procédés de sélection de sujets pour une polythérapie anticancéreuse avec un ph20 soluble conjugué à un polymère |
GR1009958B (el) * | 2019-04-24 | 2021-03-18 | ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." | Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3651045A (en) * | 1968-10-21 | 1972-03-21 | Parke Davis & Co | 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production |
EP0042596A1 (fr) * | 1980-06-23 | 1981-12-30 | The Regents Of The University Of Minnesota | Dérivés d'adénosine, leur préparation et compositions pharmaceutiques les contenant |
EP0056265A2 (fr) * | 1981-01-09 | 1982-07-21 | Dr. Thilo & Co. GmbH | Pyrimidinenucléosides estérifiés en position 5' ayant une activité antivirale, méthode pour leur préparation et les médicaments les contenant |
EP0104857A1 (fr) * | 1982-09-28 | 1984-04-04 | Beecham Group Plc | Dérivés de la déoxyuridine, leurs méthodes de préparation et leur emploi en médecine |
US4495180A (en) * | 1982-06-21 | 1985-01-22 | Merck & Co., Inc. | Prodrugs of Ara-A an antiviral agent |
EP0151189A1 (fr) * | 1983-07-20 | 1985-08-14 | Teijin Limited | Agent antineoplastique |
EP0217580A2 (fr) * | 1985-09-17 | 1987-04-08 | The Wellcome Foundation Limited | Nucléosides thérapeutiques |
EP0219829A2 (fr) * | 1985-10-18 | 1987-04-29 | Sloan-Kettering Institute For Cancer Research | Nucléosides 2-fluoro-arabinofuranosyl purine |
EP0260852A2 (fr) * | 1986-09-08 | 1988-03-23 | The Wellcome Foundation Limited | Analogues aux nucléosides |
WO1988007532A1 (fr) * | 1987-03-24 | 1988-10-06 | Nycomed A.S. | Derives d'oxyde de 2',3' didesoxyribofuranne |
EP0329348A2 (fr) * | 1988-02-16 | 1989-08-23 | Eli Lilly And Company | Nucléosides-2',3'-didéoxy-2',2'-difluoro |
EP0340778A2 (fr) * | 1988-05-06 | 1989-11-08 | Bristol-Myers Squibb Company | Prodrogues de 2',3'-didéshydro-2',3'-didésoxynucléosides |
EP0341704A2 (fr) * | 1988-05-12 | 1989-11-15 | F. Hoffmann-La Roche Ag | Procédé pour la préparation de 2',3'-didéoxycytidines |
EP0346108A2 (fr) * | 1988-06-09 | 1989-12-13 | The Wellcome Foundation Limited | Nucléosides anti-infectieux |
EP0355031A2 (fr) * | 1988-08-17 | 1990-02-21 | MATTHES, Eckart, Dr. | Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant |
EP0362967A1 (fr) * | 1988-10-05 | 1990-04-11 | Nycomed Imaging As | Dérivés de nucléosides |
EP0366171A1 (fr) * | 1988-10-05 | 1990-05-02 | Nycomed As | Dérivés de nucléosides |
EP0417999A1 (fr) * | 1989-09-11 | 1991-03-20 | The Wellcome Foundation Limited | Composés antiviraux |
-
1991
- 1991-04-04 WO PCT/EP1991/000639 patent/WO1991015498A2/fr not_active Application Discontinuation
- 1991-04-04 JP JP91506841A patent/JPH05505815A/ja active Pending
- 1991-04-04 CA CA002079796A patent/CA2079796A1/fr not_active Abandoned
- 1991-04-04 EP EP91906957A patent/EP0523110A1/fr not_active Withdrawn
- 1991-04-04 AU AU75584/91A patent/AU7558491A/en not_active Abandoned
-
1992
- 1992-10-02 OA OA60286A patent/OA09677A/en unknown
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3651045A (en) * | 1968-10-21 | 1972-03-21 | Parke Davis & Co | 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production |
EP0042596A1 (fr) * | 1980-06-23 | 1981-12-30 | The Regents Of The University Of Minnesota | Dérivés d'adénosine, leur préparation et compositions pharmaceutiques les contenant |
EP0056265A2 (fr) * | 1981-01-09 | 1982-07-21 | Dr. Thilo & Co. GmbH | Pyrimidinenucléosides estérifiés en position 5' ayant une activité antivirale, méthode pour leur préparation et les médicaments les contenant |
US4495180A (en) * | 1982-06-21 | 1985-01-22 | Merck & Co., Inc. | Prodrugs of Ara-A an antiviral agent |
EP0104857A1 (fr) * | 1982-09-28 | 1984-04-04 | Beecham Group Plc | Dérivés de la déoxyuridine, leurs méthodes de préparation et leur emploi en médecine |
EP0151189A1 (fr) * | 1983-07-20 | 1985-08-14 | Teijin Limited | Agent antineoplastique |
EP0217580A2 (fr) * | 1985-09-17 | 1987-04-08 | The Wellcome Foundation Limited | Nucléosides thérapeutiques |
EP0219829A2 (fr) * | 1985-10-18 | 1987-04-29 | Sloan-Kettering Institute For Cancer Research | Nucléosides 2-fluoro-arabinofuranosyl purine |
EP0260852A2 (fr) * | 1986-09-08 | 1988-03-23 | The Wellcome Foundation Limited | Analogues aux nucléosides |
WO1988007532A1 (fr) * | 1987-03-24 | 1988-10-06 | Nycomed A.S. | Derives d'oxyde de 2',3' didesoxyribofuranne |
EP0329348A2 (fr) * | 1988-02-16 | 1989-08-23 | Eli Lilly And Company | Nucléosides-2',3'-didéoxy-2',2'-difluoro |
EP0340778A2 (fr) * | 1988-05-06 | 1989-11-08 | Bristol-Myers Squibb Company | Prodrogues de 2',3'-didéshydro-2',3'-didésoxynucléosides |
EP0341704A2 (fr) * | 1988-05-12 | 1989-11-15 | F. Hoffmann-La Roche Ag | Procédé pour la préparation de 2',3'-didéoxycytidines |
EP0346108A2 (fr) * | 1988-06-09 | 1989-12-13 | The Wellcome Foundation Limited | Nucléosides anti-infectieux |
EP0355031A2 (fr) * | 1988-08-17 | 1990-02-21 | MATTHES, Eckart, Dr. | Nucléosides pyrimidiniques substitués, leur procédé de préparation et médicaments les contenant |
EP0362967A1 (fr) * | 1988-10-05 | 1990-04-11 | Nycomed Imaging As | Dérivés de nucléosides |
EP0366171A1 (fr) * | 1988-10-05 | 1990-05-02 | Nycomed As | Dérivés de nucléosides |
EP0417999A1 (fr) * | 1989-09-11 | 1991-03-20 | The Wellcome Foundation Limited | Composés antiviraux |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE45288E1 (en) | 2008-04-18 | 2014-12-09 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring |
USRE45325E1 (en) | 2008-04-18 | 2015-01-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring |
US9102681B2 (en) | 2008-04-18 | 2015-08-11 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
US9233998B2 (en) | 2008-04-18 | 2016-01-12 | Reata Pharmaceuticals, Inc. | Natural product analogs including an anti-inflammatory cyanoenone pharmacore and methods of use |
US9249089B2 (en) | 2008-04-18 | 2016-02-02 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives |
Also Published As
Publication number | Publication date |
---|---|
WO1991015498A2 (fr) | 1991-10-17 |
AU7558491A (en) | 1991-10-30 |
OA09677A (en) | 1993-05-15 |
CA2079796A1 (fr) | 1991-10-05 |
JPH05505815A (ja) | 1993-08-26 |
EP0523110A1 (fr) | 1993-01-20 |
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