CA2072123C - Inhibitors of purine nucleoside phosphorylase - Google Patents
Inhibitors of purine nucleoside phosphorylaseInfo
- Publication number
- CA2072123C CA2072123C CA002072123A CA2072123A CA2072123C CA 2072123 C CA2072123 C CA 2072123C CA 002072123 A CA002072123 A CA 002072123A CA 2072123 A CA2072123 A CA 2072123A CA 2072123 C CA2072123 C CA 2072123C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- cyclo
- amino
- pyrrolo
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US429,097 | 1982-09-30 | ||
US07/429,098 US4985434A (en) | 1989-10-31 | 1989-10-31 | 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same |
US07/429,099 US5008265A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US429,100 | 1989-10-31 | ||
US429,098 | 1989-10-31 | ||
US429,099 | 1989-10-31 | ||
US07/429,100 US4985433A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US07/429,097 US5008270A (en) | 1989-10-31 | 1989-10-31 | 2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
US44279889A | 1989-11-29 | 1989-11-29 | |
US442,798 | 1989-11-29 | ||
PCT/US1990/005756 WO1991006548A1 (en) | 1989-10-31 | 1990-10-12 | Inhibitors of purine nucleoside phosphorylase |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2072123A1 CA2072123A1 (en) | 1991-05-01 |
CA2072123C true CA2072123C (en) | 2001-06-12 |
Family
ID=27541578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002072123A Expired - Fee Related CA2072123C (en) | 1989-10-31 | 1990-10-12 | Inhibitors of purine nucleoside phosphorylase |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0500653A4 (fi) |
JP (1) | JP2866478B2 (fi) |
AU (1) | AU654264B2 (fi) |
CA (1) | CA2072123C (fi) |
FI (1) | FI103972B1 (fi) |
HU (1) | HUT61765A (fi) |
LV (1) | LV10100B (fi) |
NO (1) | NO301423B1 (fi) |
WO (1) | WO1991006548A1 (fi) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726311A (en) * | 1989-11-29 | 1998-03-10 | Biocryst Pharmaceuticals, Inc. | 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same |
US5236926A (en) * | 1992-02-03 | 1993-08-17 | Warner-Lambert Company | 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions |
CA2133346A1 (en) * | 1992-04-21 | 1993-10-28 | Shri Niwas | 7-disubstituted-methyl-4-oxo-3h,5h-pyrrolo[3,2-d]pyrimidine and pharmaceutical uses and compositions containing the same |
PL319485A1 (en) * | 1994-10-05 | 1997-08-04 | Chiroscience Ltd | Purinic and guanic compounds as pnp inhibitors |
GB9520363D0 (en) * | 1995-10-05 | 1995-12-06 | Chiroscience Ltd | Compounds |
GB9520364D0 (en) * | 1995-10-05 | 1995-12-06 | Chiroscience Ltd | Compouundds |
CA2288317A1 (en) * | 1997-05-29 | 1998-12-03 | Benjamin Biro Mugrage | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydro-pyrrolo¬3,2-d|pyrimidin-4-ones |
US6174888B1 (en) | 1998-05-28 | 2001-01-16 | Novartis Ag | 2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones |
JP4496586B2 (ja) * | 2000-01-24 | 2010-07-07 | 日産化学工業株式会社 | キノリルアクリロニトリルの製造法及びその中間体 |
CN100379750C (zh) * | 2002-08-21 | 2008-04-09 | 阿尔伯爱因斯坦医科叶希瓦大学 | 核苷磷酸化酶和核苷酶抑制剂 |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
CA2710039C (en) | 2007-12-26 | 2018-07-03 | Critical Outcome Technologies, Inc. | Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer |
EP3023426A1 (en) | 2008-07-17 | 2016-05-25 | Critical Outcome Technologies, Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
EP2552915B1 (en) | 2010-04-01 | 2017-07-19 | Critical Outcome Technologies Inc. | Compounds for the treatment of hiv |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5988484A (ja) * | 1982-11-09 | 1984-05-22 | Takeda Chem Ind Ltd | 新規7−デアザプリン誘導体 |
IE60433B1 (en) * | 1986-08-26 | 1994-07-13 | Warner Lambert Co | Novel 9-deazaguanines |
CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
US4921858A (en) * | 1986-10-24 | 1990-05-01 | Warner-Lambert Company | 7-deazaguanines as immunomodulators |
DE3726044A1 (de) * | 1987-02-11 | 1988-08-25 | Bayer Ag | Akarizide mittel auf basis von azomethinderivaten und azomethine des 2,3-diaminomaleinsaeurenitrils |
US4927830A (en) * | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
ES2106732T3 (es) * | 1989-02-27 | 1997-11-16 | Biocryst Pharm Inc | Desazaguaninas substituidas en 9 y no substituidas en 8. |
US4985434A (en) * | 1989-10-31 | 1991-01-15 | Biocryst, Inc. | 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same |
US4985433A (en) * | 1989-10-31 | 1991-01-15 | Biocryst, Inc. | 2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same |
-
1990
- 1990-10-12 WO PCT/US1990/005756 patent/WO1991006548A1/en not_active Application Discontinuation
- 1990-10-12 JP JP2515550A patent/JP2866478B2/ja not_active Expired - Lifetime
- 1990-10-12 CA CA002072123A patent/CA2072123C/en not_active Expired - Fee Related
- 1990-10-12 HU HU9201450A patent/HUT61765A/hu unknown
- 1990-10-12 EP EP90916628A patent/EP0500653A4/en not_active Withdrawn
- 1990-10-12 AU AU67125/90A patent/AU654264B2/en not_active Ceased
-
1992
- 1992-04-28 FI FI921900A patent/FI103972B1/fi active
- 1992-04-29 NO NO921679A patent/NO301423B1/no not_active IP Right Cessation
-
1993
- 1993-05-14 LV LVP-93-342A patent/LV10100B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0500653A1 (en) | 1992-09-02 |
LV10100A (lv) | 1994-05-10 |
WO1991006548A1 (en) | 1991-05-16 |
CA2072123A1 (en) | 1991-05-01 |
NO921679L (no) | 1992-06-17 |
JP2866478B2 (ja) | 1999-03-08 |
FI103972B (fi) | 1999-10-29 |
HU9201450D0 (en) | 1992-09-28 |
FI921900A (fi) | 1992-04-28 |
HUT61765A (en) | 1993-03-01 |
AU6712590A (en) | 1991-05-31 |
EP0500653A4 (en) | 1995-08-23 |
FI921900A0 (fi) | 1992-04-28 |
JPH05504551A (ja) | 1993-07-15 |
FI103972B1 (fi) | 1999-10-29 |
NO921679D0 (no) | 1992-04-29 |
LV10100B (en) | 1995-08-20 |
AU654264B2 (en) | 1994-11-03 |
NO301423B1 (no) | 1997-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |