CA2071872A1 - Cytokine antibody for the treatment of sepsis - Google Patents
Cytokine antibody for the treatment of sepsisInfo
- Publication number
- CA2071872A1 CA2071872A1 CA002071872A CA2071872A CA2071872A1 CA 2071872 A1 CA2071872 A1 CA 2071872A1 CA 002071872 A CA002071872 A CA 002071872A CA 2071872 A CA2071872 A CA 2071872A CA 2071872 A1 CA2071872 A1 CA 2071872A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- csf
- cells
- monoclonal
- sepsis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 229960003343 ouabain Drugs 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
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- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
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- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- CKYLHMGDNIAAPE-UHFFFAOYSA-M sodium;4-hydroxy-3-nitrobenzenesulfonate Chemical compound [Na+].OC1=CC=C(S([O-])(=O)=O)C=C1[N+]([O-])=O CKYLHMGDNIAAPE-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45121889A | 1989-12-15 | 1989-12-15 | |
| US451,218 | 1989-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2071872A1 true CA2071872A1 (en) | 1991-06-16 |
Family
ID=23791295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002071872A Abandoned CA2071872A1 (en) | 1989-12-15 | 1990-12-13 | Cytokine antibody for the treatment of sepsis |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0506855A1 (de) |
| JP (1) | JPH05503098A (de) |
| AU (2) | AU7160391A (de) |
| CA (1) | CA2071872A1 (de) |
| WO (1) | WO1991008774A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246701A (en) * | 1990-10-05 | 1993-09-21 | Ludwig Institute For Cancer Research | Method for inhibiting production of IgE by using IL-9 inhibitors |
| EP0672144A1 (de) * | 1992-10-20 | 1995-09-20 | Chiron Corporation | Interleukin-6-receptor-antagonisten |
| JP3525221B2 (ja) * | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
| EP0724594B1 (de) | 1993-07-20 | 2009-01-14 | The Regents of the University of California | Regulation von transkriptionsfaktor, nf-il6/lap |
| US5993811A (en) | 1997-02-03 | 1999-11-30 | Biology Associates, Llc | Method and compositions for preventing and treating the systemic inflammatory response syndrome including sepsis |
| US7494652B1 (en) * | 1998-06-10 | 2009-02-24 | Promega Corporation | Treatment of sepsis |
| US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
| PT2308888T (pt) | 2001-11-14 | 2017-05-03 | Janssen Biotech Inc | Anticorpos anti-il-6, composições, métodos e utilizações |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| HUE026132T2 (en) | 2004-01-07 | 2016-05-30 | Novartis Vaccines & Diagnostics Inc | M-CSF-specific monoclonal antibody and its uses |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0111344A2 (de) * | 1982-12-13 | 1984-06-20 | Sloan-Kettering Institute For Cancer Research | Monoklonale Anti-Interleukin-2-Antikörper |
| US5041381A (en) * | 1986-07-03 | 1991-08-20 | Schering Corporation | Monoclonal antibodies against human interleukin-4 and hybridomas producing the same |
| GB8624899D0 (en) * | 1986-10-17 | 1986-11-19 | Sandoz Ltd | Monoclonal antibodies |
| DK590387A (da) * | 1986-11-13 | 1988-05-14 | Otsuka Pharma Co Ltd | Antistoffer mod interleukin-1 |
-
1990
- 1990-12-13 EP EP91902547A patent/EP0506855A1/de not_active Ceased
- 1990-12-13 WO PCT/US1990/007411 patent/WO1991008774A1/en not_active Application Discontinuation
- 1990-12-13 JP JP91502817A patent/JPH05503098A/ja active Pending
- 1990-12-13 CA CA002071872A patent/CA2071872A1/en not_active Abandoned
- 1990-12-13 AU AU71603/91A patent/AU7160391A/en not_active Abandoned
-
1995
- 1995-01-16 AU AU10221/95A patent/AU1022195A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0506855A1 (de) | 1992-10-07 |
| WO1991008774A1 (en) | 1991-06-27 |
| JPH05503098A (ja) | 1993-05-27 |
| AU1022195A (en) | 1995-04-27 |
| AU7160391A (en) | 1991-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |