CA2069645A1 - Process for dehydrating corticosteroid intermediates - Google Patents

Process for dehydrating corticosteroid intermediates

Info

Publication number
CA2069645A1
CA2069645A1 CA002069645A CA2069645A CA2069645A1 CA 2069645 A1 CA2069645 A1 CA 2069645A1 CA 002069645 A CA002069645 A CA 002069645A CA 2069645 A CA2069645 A CA 2069645A CA 2069645 A1 CA2069645 A1 CA 2069645A1
Authority
CA
Canada
Prior art keywords
formula
loweralkyl
defined hereinbefore
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002069645A
Other languages
English (en)
French (fr)
Inventor
Nicholas Carruthers
Sohaila Garshasb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2069645A1 publication Critical patent/CA2069645A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/006—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Tires In General (AREA)
CA002069645A 1989-11-27 1990-11-26 Process for dehydrating corticosteroid intermediates Abandoned CA2069645A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44150089A 1989-11-27 1989-11-27
US441,500 1989-11-27
PCT/US1990/006754 WO1991008218A1 (en) 1989-11-27 1990-11-26 Process for dehydrating corticosteroid intermediates

Publications (1)

Publication Number Publication Date
CA2069645A1 true CA2069645A1 (en) 1991-05-28

Family

ID=23753123

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002069645A Abandoned CA2069645A1 (en) 1989-11-27 1990-11-26 Process for dehydrating corticosteroid intermediates

Country Status (14)

Country Link
EP (1) EP0502112A1 (en:Method)
JP (1) JPH05504561A (en:Method)
KR (1) KR927003619A (en:Method)
AU (1) AU636433B2 (en:Method)
CA (1) CA2069645A1 (en:Method)
HU (1) HUT61030A (en:Method)
IE (1) IE904252A1 (en:Method)
IL (1) IL96459A0 (en:Method)
MY (1) MY105302A (en:Method)
NZ (1) NZ236206A (en:Method)
PT (1) PT95988A (en:Method)
TW (1) TW218022B (en:Method)
WO (1) WO1991008218A1 (en:Method)
ZA (1) ZA909444B (en:Method)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108033990A (zh) * 2017-12-29 2018-05-15 广西万德药业有限公司 地塞米松中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102907A (en) * 1977-03-07 1978-07-25 The Upjohn Company Desulfinylation process for preparing androsta-4,9(11)-diene-3,17-dione
US4127596A (en) * 1977-04-11 1978-11-28 The Upjohn Company Non-aromatic oxygenated strong acid dehydration of 9α-hydroxyandrostenediones
FR2493324B1 (en:Method) * 1980-11-05 1983-01-21 Roussel Uclaf
US4585590A (en) * 1984-02-03 1986-04-29 The Upjohn Company Cyanohydrin process
US5352809A (en) * 1986-10-10 1994-10-04 Gist-Brocades N.V. 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids
PT87687B (pt) * 1987-06-12 1992-09-30 Gist Brocades Nv Processo para a preparacao de esteroides de 9(11)-dehidro
AU618350B2 (en) * 1988-04-08 1991-12-19 Aventis Pharma S.A. 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids

Also Published As

Publication number Publication date
NZ236206A (en) 1993-03-26
AU6962591A (en) 1991-06-26
MY105302A (en) 1994-09-30
WO1991008218A1 (en) 1991-06-13
ZA909444B (en) 1991-08-28
IL96459A0 (en) 1991-08-16
EP0502112A1 (en) 1992-09-09
HU9201750D0 (en) 1992-08-28
KR927003619A (ko) 1992-12-18
AU636433B2 (en) 1993-04-29
IE904252A1 (en) 1991-06-05
HUT61030A (en) 1992-11-30
PT95988A (pt) 1991-09-13
JPH05504561A (ja) 1993-07-15
TW218022B (en:Method) 1993-12-21

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Legal Events

Date Code Title Description
FZDE Discontinued