CA2064712A1 - Methode et appareil d'administration d'un anticoagulant a une suspension de globules rouges d'un separateur de sang - Google Patents

Methode et appareil d'administration d'un anticoagulant a une suspension de globules rouges d'un separateur de sang

Info

Publication number
CA2064712A1
CA2064712A1 CA2064712A CA2064712A CA2064712A1 CA 2064712 A1 CA2064712 A1 CA 2064712A1 CA 2064712 A CA2064712 A CA 2064712A CA 2064712 A CA2064712 A CA 2064712A CA 2064712 A1 CA2064712 A1 CA 2064712A1
Authority
CA
Canada
Prior art keywords
anticoagulant
cell suspension
red cell
blood
separator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2064712A
Other languages
English (en)
Other versions
CA2064712C (fr
Inventor
Donald W. Schoendorfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Donald W. Schoendorfer
Baxter International Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Donald W. Schoendorfer, Baxter International Inc. filed Critical Donald W. Schoendorfer
Publication of CA2064712A1 publication Critical patent/CA2064712A1/fr
Application granted granted Critical
Publication of CA2064712C publication Critical patent/CA2064712C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/302—Details having a reservoir for withdrawn untreated blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/303—Details having a reservoir for treated blood to be returned
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/305—Control of inversion point between collection and re-infusion phase
    • A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

Procédé et appareil de séparation par machine de sang et de constituants du sang consistant en l'administration améliorée d'anticoagulant à la sortie de suspension de globules rouges. On ajoute un anticoagulant (20) au sang total entrant (13) en une dose suffisante pour empêcher la coagulation du sang total dans le chemin d'écoulement en amont du séparateur (46) de constituants du sang, mais en une dose insuffisante pour empêcher la coagulation de la suspension des globules rouges créée par le séparateur. On ajoute un anticoagulant (20) à la suspension de globules rouges en aval (50) du séparateur (46) afin d'empêcher la coagulation. Le fait d'ajouter un aliquot supplémentaire d'anticoagulant à la suspension de globules rouges permet de réduire ou d'éliminer la dose d'anticoagulant ajoutée au sang total avant la séparation, ce qui a pour effet d'augmenter le rendement plaquettaire pendant l'étape de séparation des constituants du sang.
CA002064712A 1990-06-14 1991-06-12 Methode et appareil d'administration d'un anticoagulant a une suspension de globules rouges d'un separateur de sang Expired - Lifetime CA2064712C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/538,306 US5135667A (en) 1990-06-14 1990-06-14 Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator
US7/538,306 1990-06-14

Publications (2)

Publication Number Publication Date
CA2064712A1 true CA2064712A1 (fr) 1991-12-15
CA2064712C CA2064712C (fr) 1999-04-06

Family

ID=24146354

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002064712A Expired - Lifetime CA2064712C (fr) 1990-06-14 1991-06-12 Methode et appareil d'administration d'un anticoagulant a une suspension de globules rouges d'un separateur de sang

Country Status (6)

Country Link
US (1) US5135667A (fr)
EP (3) EP0486681B1 (fr)
JP (1) JP3062662B2 (fr)
CA (1) CA2064712C (fr)
DE (2) DE69132172T2 (fr)
WO (1) WO1991019561A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656163A (en) * 1987-01-30 1997-08-12 Baxter International Inc. Chamber for use in a rotating field to separate blood components
US5792372A (en) * 1987-01-30 1998-08-11 Baxter International, Inc. Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma
US5370802A (en) 1987-01-30 1994-12-06 Baxter International Inc. Enhanced yield platelet collection systems and methods
US5676841A (en) * 1991-12-23 1997-10-14 Baxter International Inc. Blood processing systems and methods which monitor citrate return to the donor
US5690835A (en) 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US6007725A (en) 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5549834A (en) 1991-12-23 1996-08-27 Baxter International Inc. Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes
US5833866A (en) * 1991-12-23 1998-11-10 Baxter International Inc. Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
US5681273A (en) * 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
CA2103911C (fr) * 1991-12-23 1999-08-24 Warren P. Williamson, Iv Centrifugeur avec cuve et corps separables permettant l'acces a la chambre de separation
DE4227695C1 (de) * 1992-08-21 1993-10-07 Fresenius Ag Zentrifuge zum Auftrennen von Blut in seine Bestandteile
WO1994012223A1 (fr) * 1992-12-01 1994-06-09 Haemonetics Corporation Appareil et procede de pherese des globules rouges
EP0773805A1 (fr) * 1993-02-18 1997-05-21 Baxter International Inc. Systeme d'apherese comprenant un autre site possible d'addition d'anticoagulant
US5614106A (en) * 1993-03-12 1997-03-25 Baxter International Inc. Method and apparatus for collection of platelets
ATE272311T1 (de) * 1993-03-23 2004-08-15 Cbr Lab Inc Verfahren und vorrichtung zur einkapselung biologisch aktiver substanzen in zellen
DE69425644T2 (de) * 1993-07-26 2001-04-19 Baxter Int Apparat zur Auftrennung der Blutbestandteile mit geregelter Zugabe von Antikoagulantien
US5427695A (en) 1993-07-26 1995-06-27 Baxter International Inc. Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate
JPH08506984A (ja) * 1993-12-22 1996-07-30 バクスター、インターナショナル、インコーポレイテッド 向上された可視性を有する自己プライミング滴下チャンバー
EP0744892B1 (fr) 1994-12-16 2003-12-03 Baxter International Inc. Compositions anticoagulantes pour plaquettes
US5720921A (en) * 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US6074605A (en) * 1995-03-10 2000-06-13 Entremed, Inc. Flow electroporation chamber and method
US6773669B1 (en) 1995-03-10 2004-08-10 Maxcyte, Inc. Flow electroporation chamber and method
US6251284B1 (en) 1995-08-09 2001-06-26 Baxter International Inc. Systems and methods which obtain a uniform targeted volume of concentrated red blood cells in diverse donor populations
US6527957B1 (en) 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US5762791A (en) * 1995-08-09 1998-06-09 Baxter International Inc. Systems for separating high hematocrit red blood cell concentrations
US5637082A (en) * 1996-02-22 1997-06-10 Haemonetics Corporation Adaptive apheresis apparatus
US5783093A (en) * 1997-01-02 1998-07-21 Haemonetics Corporation Blood cell concentrates using a single solution for anticoagulation and preservation
US6200287B1 (en) 1997-09-05 2001-03-13 Gambro, Inc. Extracorporeal blood processing methods and apparatus
ATE523217T1 (de) 2000-03-09 2011-09-15 Caridianbct Inc Extrakorporale vorrichtung zur blutverarbeitung
WO2002062482A2 (fr) 2000-11-02 2002-08-15 Gambro, Inc. Dispositifs de separation de fluides, systemes et / ou procedes reposant sur l'utilisation d'une configuration a entrainement par pression fluidique et / ou equilibree
US6471855B1 (en) 2000-11-22 2002-10-29 Baxter International Inc. Cassette with integral separation device
US7029916B2 (en) * 2001-02-21 2006-04-18 Maxcyte, Inc. Apparatus and method for flow electroporation of biological samples
US20030141260A1 (en) * 2001-12-28 2003-07-31 Frank Corbin Oxygen-enhanced pathogen inactivation
DK2574662T3 (da) * 2001-08-22 2021-09-20 Maxcyte Inc Fremgangsmåde til elektroporation af biologiske prøver
WO2003026599A1 (fr) * 2001-09-26 2003-04-03 The Procter & Gamble Company Compositions nettoyantes pour l'hygiene corporelle, contenant des adhesifs qui renferment de la resine silicone
US6863821B2 (en) 2002-02-02 2005-03-08 Baxter International Inc. Shear-enhanced systems and methods for removing waste materials and liquid from the blood
AU2003220295B2 (en) 2002-03-14 2007-10-18 Fenwal, Inc. Biological fluid sampling apparatus
EP1565555A4 (fr) * 2002-09-30 2008-07-09 Maxcyte Inc Appareil et procede d'electroporation non statique
FR2850581B1 (fr) * 2003-02-03 2005-09-09 Maco Pharma Sa Systeme a poches de prelevement a boucle preformee
CN102268425B (zh) * 2004-05-12 2015-02-25 麦克赛特股份有限公司 与可调流式电穿孔室相关的方法和装置
DE102005040518B4 (de) * 2005-08-26 2008-04-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Filtrationsüberwachung von Blutkonserven
US7935043B2 (en) * 2007-12-26 2011-05-03 Caridianbct, Inc. Methods and apparatus for controlled addition of solutions to blood components
US8628489B2 (en) 2008-04-14 2014-01-14 Haemonetics Corporation Three-line apheresis system and method
US8454548B2 (en) 2008-04-14 2013-06-04 Haemonetics Corporation System and method for plasma reduced platelet collection
US8702637B2 (en) 2008-04-14 2014-04-22 Haemonetics Corporation System and method for optimized apheresis draw and return
US8961789B2 (en) 2008-10-31 2015-02-24 Baxter International Inc. Systems and methods for performing hemodialysis
US8834402B2 (en) * 2009-03-12 2014-09-16 Haemonetics Corporation System and method for the re-anticoagulation of platelet rich plasma
WO2012060848A1 (fr) 2010-11-05 2012-05-10 Haemonetics Corporation Système et procédé pour le lavage de plaquettes automatisé
US9302042B2 (en) 2010-12-30 2016-04-05 Haemonetics Corporation System and method for collecting platelets and anticipating plasma return
US8469916B2 (en) 2011-02-28 2013-06-25 Fenwal, Inc. Systems and methods for single needle continuous plasma processing
US10130751B2 (en) 2011-03-11 2018-11-20 Fenwal, Inc. Membrane separation and washing devices, systems and methods employing same, and data management systems and methods
BR112013022656B1 (pt) 2011-03-11 2021-06-22 Fenwal, Inc Sistema de coleta de sangue automático de passagem única
US9164079B2 (en) 2011-03-17 2015-10-20 Greyledge Technologies Llc Systems for autologous biological therapeutics
US11386993B2 (en) 2011-05-18 2022-07-12 Fenwal, Inc. Plasma collection with remote programming
US20140231365A1 (en) 2012-07-30 2014-08-21 Fenwal, Inc. Optical Detection Of Lipids
EP2932991A1 (fr) 2012-09-10 2015-10-21 Fenwal, Inc. Dispositifs de séparation à membrane, systèmes et procédés utilisant ceux-ci, et systèmes et procédés de gestion de données
KR20150095759A (ko) * 2012-12-13 2015-08-21 가부시끼가이샤 제이엠에스 혈액성분 분리수용장치 및 다혈소판혈장의 조제방법
US10376620B2 (en) 2015-04-02 2019-08-13 Fenwal, Inc. Systems and methods for leukoreducing a red blood cell-containing fluid and concentrated red blood cells
CN113134122B (zh) 2015-09-14 2022-05-10 汾沃有限公司 存储、处理和/或加工血液和血液成分的设备、系统和方法
US10758652B2 (en) 2017-05-30 2020-09-01 Haemonetics Corporation System and method for collecting plasma
US10792416B2 (en) 2017-05-30 2020-10-06 Haemonetics Corporation System and method for collecting plasma
WO2019195414A1 (fr) * 2018-04-03 2019-10-10 Fenwal, Inc. Procédés de plasmaphérèse
HUE056564T2 (hu) 2018-05-21 2022-02-28 Fenwal Inc Rendszerek plazmagyûjtõ térfogatok optimalizálására
US11412967B2 (en) 2018-05-21 2022-08-16 Fenwal, Inc. Systems and methods for plasma collection
KR20230133893A (ko) * 2021-01-22 2023-09-19 펜월, 인크. 혈장 수집을 위한 시스템들 및 방법들
CN115025828B (zh) * 2022-05-19 2024-03-29 费森尤斯卡比(广州)医疗用品有限公司 一种血液科抗凝剂添加装置

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680025A (en) * 1982-08-24 1987-07-14 Baxter Travenol Laboratories, Inc. Blood component collection systems and methods
SE451946B (sv) * 1982-12-10 1987-11-09 Gambro Lundia Ab Anordning for avlegsnande av en eller flera fraktioner ur helblod, plasma eller liknande kroppsvetskor
US5034135A (en) * 1982-12-13 1991-07-23 William F. McLaughlin Blood fractionation system and method
DE3302804C2 (de) * 1983-01-28 1985-03-14 Fresenius AG, 6380 Bad Homburg Vorrichtung zur Entfernung von Wasser aus Blut
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
EP0156496B1 (fr) * 1984-02-24 1989-05-17 Kuraray Co., Ltd. Appareil pour le traitement du plasma
EP0310205B1 (fr) * 1984-03-21 1994-07-20 McLaughlin, William Francis Filtration d'une suspension liquide
US4776964A (en) * 1984-08-24 1988-10-11 William F. McLaughlin Closed hemapheresis system and method
US4713176A (en) * 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
US4806247A (en) * 1985-04-12 1989-02-21 Baxter International Inc. Plasmapheresis system and method
US4871462A (en) * 1985-12-23 1989-10-03 Haemonetics Corporation Enhanced separation of blood components
US4842576A (en) * 1986-10-15 1989-06-27 Baxter International Inc. System for generating substantially constant fluid pressure
DE3853298T2 (de) * 1987-01-13 1995-11-09 Mclaughlin William F Zentrifugaltrenner.
US4769001A (en) * 1987-02-25 1988-09-06 Baxter International Inc. Method and apparatus for calibrating plural pump fluid flow system
EP0305364B2 (fr) * 1987-02-25 1998-01-07 BAXTER INTERNATIONAL INC. (a Delaware corporation) Systeme de purge pour un reseau de tuyaux transportant du sang
US4850998A (en) * 1987-10-07 1989-07-25 Baxter International Inc. Method for wetting a plasmapheresis filter with anticoagulant
US4851126A (en) * 1987-11-25 1989-07-25 Baxter International Inc. Apparatus and methods for generating platelet concentrate
US4954128A (en) * 1988-08-23 1990-09-04 Baxter International Inc. Therapeutics plasma exchange system
US4897185A (en) * 1988-10-06 1990-01-30 Cobe Laboratories, Inc. Cell processing apparatus and method
DE3837298C1 (fr) * 1988-11-03 1990-03-29 Fresenius Ag, 6380 Bad Homburg, De

Also Published As

Publication number Publication date
EP0486681B1 (fr) 1996-09-11
EP0664135A1 (fr) 1995-07-26
EP0664135B1 (fr) 2000-05-03
EP0486681A4 (en) 1993-01-27
DE69122042T2 (de) 1997-04-10
JPH05502609A (ja) 1993-05-13
CA2064712C (fr) 1999-04-06
DE69132172T2 (de) 2001-01-25
US5135667A (en) 1992-08-04
DE69132172D1 (de) 2000-06-08
DE69122042D1 (de) 1996-10-17
JP3062662B2 (ja) 2000-07-12
EP0968731A1 (fr) 2000-01-05
EP0486681A1 (fr) 1992-05-27
WO1991019561A1 (fr) 1991-12-26

Similar Documents

Publication Publication Date Title
CA2064712A1 (fr) Methode et appareil d'administration d'un anticoagulant a une suspension de globules rouges d'un separateur de sang
CA2064694A1 (fr) Methode automatisee de separation des composes du sang et appareil permettant differentes caracteristiques fonctionnelles dans des composantes multiples du sang
CA2198696A1 (fr) Jouets doues de possibilites de mouvements avec lent retour a la position originelle
CA2306829A1 (fr) Sensibilisation automatiques de dispositifs sanguins
EP0879608A3 (fr) Dispositif et méthode de separation de sang en ses composants
SE9301418D0 (sv) System och metod foer behandling av biologiska vaetskor
FR2419058A1 (fr) Separation des lymphocytes d'une suspension en contenant, par filtration
KR910000211A (ko) 혈액 성분 분리방법 및 분리장치
JPS5263178A (en) Gas separation unit
ATE207382T1 (de) Membranfiltration mit optimierter leistung
EP0402698A3 (fr) Système de stockage pour les globules rouges du sang pauvre en leukocites
ES8404057A1 (es) Procedimiento para la precipitacion extracorporea selectiva de lipoproteinas de baja densidad o b-lipoproteinas
HK1077240A1 (en) Method and device for separating whole blood into an erythrocyte concentrate and cell-free or thrombocyte-containing plasma under gravitational force
EP0261530A3 (en) Method and apparatus for separating the components of blood taken "in vivo" from a donor
CA2153010A1 (fr) Filtre servant a l'elimination d'agents photoactifs
EP0259834A3 (en) Method of classifying leucocytes by flow cytometry
AU560493B2 (en) Plasmapheresis by membrane filtration
JPS57108101A (en) Microporous cellulose membrane, manufacture, blood plasma separation and microfiltration
EP0367475A3 (fr) Procédé de préparation d'un concentré d'hémoglobine
ATE299720T1 (de) Verfahren zur herstellung eines thrombozytenpräparates
McLeod et al. Complement metabolism during membrane plasma separation
EP0156367A3 (fr) Procédé et appareil de triage
CA2194270A1 (fr) Procede et systeme de mise en culture de cellules notamment de macrophages
ES8201595A1 (es) Un procedimiento para la purificacion de glucosaminoglucanos
JPS54119016A (en) Separation of lymphocyte

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202