US4769001A - Method and apparatus for calibrating plural pump fluid flow system - Google Patents

Method and apparatus for calibrating plural pump fluid flow system Download PDF

Info

Publication number
US4769001A
US4769001A US06802330 US80233085A US4769001A US 4769001 A US4769001 A US 4769001A US 06802330 US06802330 US 06802330 US 80233085 A US80233085 A US 80233085A US 4769001 A US4769001 A US 4769001A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
fluid
path
pump
pumps
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US06802330
Inventor
Paul R. Prince
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3639Blood pressure control, pressure transducers specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3643Priming, rinsing before or after use
    • A61M1/3644Mode of operation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3643Priming, rinsing before or after use
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/70General characteristics of the apparatus with testing or calibration facilities
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/13Infusion monitoring

Abstract

A blood constituent processing system uses a disposable plastic fluid flow path into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path are then monitored and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path. The relative pump flow control required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar arrangement may be used to derive relative flow calibration constants for the blood pump and a packed cell pump also present in the blood constituent processing system.

Description

This invention generally relates to method and apparatus for calibrating relative pump flow rates between plural pumps in a common fluid flow system. The invention is particularly suited for accurately calibrating relative fluid flow rates achieved by independent pumps within a disposable plastic fluid flow path of a blood constituent processing system.

Where plural independently controlled pumps are included in a common fluid flow system, it is sometimes necessary to accurately calibrate the relative flow rates between the various pumps within the system. For example, a typical blood constituent processing system may add a metered quantity of anticoagulant into a pumped flow of blood constituents. Such requirements may typically arise in a blood plasma filtering system (e.g. where whole blood is extracted from a donor, processed to remove plasma and to return the residual packed red blood cells to the donor) and/or in a platelet separation system (e.g. where whole blood from a donor is processed to remove platelets and/or plasma and the residual blood constituents are returned to the donor).

In such a blood constituent processing system, there may also be a desire to accurately calibrate the relative flow rates of the blood pumped into a filter (or other fractionating device) and the packed cells output from the filter (and/or of the filtrated or separated fraction also being output from the filter).

In such blood constituent processing systems, for obvious health reasons, the fluid flow path is typically defined by disposable plastic tubing. Such tubing may be manually inserted into conventional pulsatile pumps (e.g. where a rotating member periodically engages and compresses the tubing in a travelling wave type of motion so as to positively displace any fluid contained within the tubing in a pulsatile manner and in a direction determined by the direction of rotation), electromagnetically operated clamps (e.g. to act as "on/off" valves which controllably pinch or close off the plastic tubing at desired control points), etc. The rotational motion of each pump may be electrically monitored using hall-effect pulse generators. In one type of system, a branched section of the tubing includes a trapped compressible gas communicating with a pressure sensor so as to permit fluid pressure variations to be monitored.

Variations from one set of disposable plastic tubing to another (e.g., as further influenced by instantaneous variations in ambient temperature, pressures, flow rates, etc.) may cause significant flow variations. For example, in one exemplary system, the blood pump may experience flow variations of 10 to 15% and the anticoagulant pump may experience variations of up to approximately 10% due to variations from one set of disposable tubing to the next. At the same time, the metering ratio of anticoagulant flow to whole blood flow must typically be controlled with a greater precision to insure proper overall operation of the blood constituent processing system (e.g. for proper platelet survival).

During an initial "priming" mode of such blood constituent processing systems, it is typical to have a fluid flow path (e.g. including the anticoagulant insertion line and the whole blood extraction line) disposed between two pumps (e.g. the anticoagulant metering pump and the whole blood extraction pump) filled with liquid and including an arrangement for monitoring the fluid pressure in this fluid flow path (e.g. a trapped air or other gas or fluid column extending to a pressure sensor).

This invention provides method and apparatus for more accurately calibrating the actual fluid flow rates of the anticoagulant pump and the whole blood pump during this initial "set up" or priming mode. For example, the fluid flow path extending between the two pumps may be closed (e.g. by a hemastat or clamp temporarily placed at the juncture of the anticoagulant input tubing and the whole blood extraction tubing) so as to form a closed fluid system between the two pumps (e.g. typically filled with anticoagulant solution and a saline solution and a trapped air or gas region communicating with a pressure sensor). Both pumps may then be commanded to run at the same nominal flow rate and any resulting changes in the monitored pressure of the closed fluid flow system are then detected and used to adjust the commanded pumping rate of at least one of the pumps in a direction and by an amount required to null the value of such detected pressure changes with respect to time.

Alternatively, a change with respect to time in the liquid volume within the closed fluid system may be observed and driven to zero. In this configuration, the fluid system between the pumps need not be closed.

At the end of such calibration procedure, one will know the relative pump flow control commands required to actually achieve equal flow rates and, accordingly, this provides a relative flow rate calibration factor relating the actual flow rate of one pump to the other with a particular set of disposable plastic tubing in place.

It is also possible to use this invention to calibrate the blood pump relative to the packed cell pump in a typical plasmapheresis system where the rate of plasma filtrate extraction is determined by the difference between the pumped blood input rate and the pumped packed cell output rate. Here there is also typically an available pressure sensor located in the fluid system between these two pumps. During an initial calibration phase, the plasma filtrate output line may be temporarily clamped shut while the blood pump and packed cell pump rates are adjusted to achieve a constant average fluid pressure therebetween. The required relative pump driving rate then provides a relative fluid flow rate calibration between these two pumps.

Viewed from an overall perspective, the invention thus provides apparatus and method for deriving relative flow characteristics of plural pumps fluid-connected to a common closed fluid path by measuring the relative pump flow controls which are required to maintain an approximately constant average fluid pressure (or a constant average fluid volume) in the path while one pump is injecting fluid and the other pump is withdrawing fluid from the path. Alternatively, it may be possible in some circumstances to measure the time-based rate of pressure change in the fluid path and then to calculate or deduce the required calibration factor based on the measured rate of change. Still further, it may be possible to alternately activate the individual pumps to inject and/or to withdraw fluid from the closed path while measuring changes in fluid pressure or volume therewithin so as to deduce the relative flow characteristics of the plural pumps connected to the common closed fluid path.

These as well as other objects and advantages of the invention may be better appreciated by carefully studying the following detailed description of a presently preferred exemplary embodiment, when taken in conjunction with the accompanying drawings, of which:

FIG. 1 is a schematic block diagram of an exemplary apparatus which may be used for practicing the method of this invention;

FIG. 2 is a flow diagram of a suitable computer controlling subroutine or program for the pump controller of FIG. 1;

FIG. 3 is an explanatory graph depicting typical pressure changes with respect to time in the closed fluid flow path of FIG. 1;

FIG. 4 is a schematic depiction of a portion of a blood constituent processing system which embodies a closed fluid flow path between two independently controlled pumps in a manner which is similar to that depicted in FIG. 1;

FIG. 5 is a schematic block diagram of a control system which may be suitable for use as the controller in the apparatus of FIGS. 1 and/or 4;

FIG. 6 is similar to FIG. 4 but depicts a different portion of a blood constituent processing system where a blood pump and a packed cell pump are flow calibrated relative to one another; and

FIG. 7 is a graphical depiction of pressure changes versus pump flow error rate.

The system of FIG. 1 includes plural pumps (e.g. pump #1 and pump #2) interconnected by a closed fluid flow path 12 (e.g. a disposable plastic tubing as in a blood constituent processing system). In the exemplary embodiment, pump #1 and pump #2 are both peristaltic pumps of conventional design. During sustained system operation, a fluid may be input at 14 (e.g. whole blood) and mixed with a metered supply of fluid #1 (e.g. an anticoagulant solution) while being pumped onward to other portions of the apparatus at 16 (e.g. to a plasma or platelet separator/filter device, etc.) Another fluid supply #2 may also be connected with pump #2 (e.g. so as to provide a source of saline solution during initial priming mode operations or the like). A pressure measuring branch 18 of the closed fluid flow path may typically include a trapped air portion communicating with an air pressure transducer 20. An overall system controller may include a microprocessor-based pump controller 22 which is capable of independently controlling the flow rates of pump #1 and pump #2 and which also has access to pressure data derived from the air pressure transducer 20. Those in the art will recognize that there may be many other configurations of a closed fluid flow path extending between plural pumps which may be independently controlled and for which accurate relative flow rate calibration factors are desired.

In this exemplary embodiment, the relative pump flow calibration system includes a closed fluid flow path which has both incompressible liquids and compressible gases therewithin such that that gas pressure can be used to monitor pressure variations. A relative flow rate calibration of the two pumps with respect to each other is obtained by constraining the system to pump into the closed flow path with one pump and to pump out of the closed flow path with the other pump using nominally identical flow commands. If the pumps actually have equal flow rate calibration factors, then there should be a substantially constant pressure maintained within the interconnecting closed fluid flow path. By monitoring any detected pressure (or contained fluid quantity) variations within the closed fluid flow path, any calibration errors can be detected.

The hardware architecture of the microprocessor-based pump controller 22 may be of conventional design (e.g. a microprocessor chip, RAM/ROM chips, I/O chips, analog-to-digital converters, etc. conventionally interconnected). Similarly, insofar as an understanding and utilization of the present invention is concerned, the computer controlling program or software during normal system operation may be of conventional design (possibly modified so as to include a multiplicative calibration factor when generating pump control commands).

However, during a calibration period, the controller 22 also may be programmed so as to practice the method of this invention. One example of such a program is depicted in the flow chart of FIG. 2 (albeit those in the art will recognize that, in accordance with the principles of this invention as here explained, one may devise many different but suitable computer programs). A "hardwired" controller can also be readily designed to practice this invention as will also be readily appreciated by those in the art.

Upon entry into the pump calibrate subroutine 200 of FIG. 2, some initial "housekeeping" details may be attended to such as those depicted at block 202. For example, a counter N may be reset to a contents of 1 and a visual operator display may be activated so as to request closure of the fluid path interconnecting the plural pumps in the system (e.g. by closing the valves near inlet 14 and outlet 16 or by applying suitable hemostats, clamps, etc.) Alternatively, if the system includes suitably placed electromagnetically controlled tubing clamps or the like, then the controller 22 may automatically close off a fluid flow path interconnecting the plural pumps in the system.

A check may be made at step 204 for the existence of a closed fluid system (e.g. by monitoring a manually activated switch and/or by performing automated stimulus/response testing routines as will be apparent). Once a properly closed fluid system is in place, control is passed to step 206 where pump #1 is activated to insert fluid into the closed system at a pump rate X while pump #2 is simultaneously activated to extract fluid from the closed system at pump rate Y--the nominal pump rates X and Y being initially selected to be equal.

A pressure reading is then taken at 208 (possibly after some finite "settling" time to permit start up of the pumps) after which a wait loop is entered at step 210 (e.g. 4.25 seconds). Upon exit from the wait loop 210, a new pressure reading is taken at 212 and tested at 214 so as to detect any pressure changes in excess of some predetermined positive or negative "noise" value. If a significant pressure change is detected, then in block 215 a correction term proportional to the error (through multiplication factor Kg) is applied, and control is passed to block 216 where it is determined whether the pressure change is in the increasing or decreasing direction. If the pressure change increased, then the pump rate Y of pump #2 is increased (or, alternatively, the pump rate X is decreased) by the correction term and control is passed back to the wait loop 210. On the other hand, if the pressure change was in the decreasing direction, then pump rate Y is decreased (or, alternatively, pump rate X is increased) by a suitable correction term and control is again passed back to the wait loop 210.

If no significant pressure change is observed, then the N counter is tested at 222 to see if it yet equals a maximum preset value corresponding to the required time interval of approximately constant pressure. If the required constant pressure period is not yet at hand, then the N counter is incremented at 224 and control is passed back to the wait loop 210. On the other hand, after a sufficiently long period of constant pressure has been detected, then exit will be made to block 226 where the then existing relative pump rates X, Y will be stored away as pump flow calibration factors and a normal exit may be made at 228 from the pump calibrate subroutine.

A typical graph of pressure variations within the closed flow path as a function of time during operation of the calibration process is depicted at FIG. 3. Here, it will be seen that an initial portion of the pressure versus time curve exhibits a slope which itself indicates the relative pump calibration error. As will be understood, it may be possible to measure the value of this slope and calculate the appropriate pump flow calibration factors X, Y directly based upon such a slope measurement. However, such measurement involves some error since slope is proportional to flow rate errors and volume of trapped air 19 (see FIG. 1). After matched pump calibration has been achieved, it will be seen in FIG. 3 that the slope of the pressure versus time curve reduces to an approximately zero value.

FIG. 4 is similar to FIG. 1 but more realistically depicts a portion of a typical blood constituent processing system and a portion of a typical disposable plastic tubing harness which is typically threaded into various pumping, clamping, pressure sensing, etc. apparatus which is, in turn, under control of a microprocessor-based controller. During a priming mode, the fluid flow path between the anticoagulant pump and the blood pump is filled with liquid (thereby trapping a quantity of air in a pressure measuring branch of the tubing communicating with the pressure sensor). A hemostat or clamp is then placed at the junction of the anticoagulant tubing and of the blood extraction tubing so that the two liquids (anticoagulant solution and saline solution in this preliminary priming mode) form a closed system between the two pumps, with the air region and pressure sensor monitoring the closed system.

Pressure then builds up or falls as the two pumps are commanded to produce the same nominal flow rate. A control system such as that depicted in FIG. 5 automatically observes the pressure changes over a time period and responsively controls at least one of the pumps to change its actual flow rate. As previously mentioned, the necessary calibration factor relating the relative actual flow rates of the pumps with a given disposable plastic tubing harness in place may be obtained by measuring the slope or rate of change of the pressure versus time curve and/or by empirically modifying the relative pump calibration factors so as to null any detected pressure changes. For example, a modified pump flow constant may be generated so as to direct one of the pumps actually to rotate faster or slower for a specified nominal liquid flow rate. After sufficient precision has been attained, the calibration procedure is complete.

In one exemplary embodiment, as depicted in FIG. 5, both pumps are initially commanded to flow at a rate of 10 milliliters per minute as represented schematically at block 500 in FIG. 5. This command is multiplied by an anticoagulant pump flow constant or calibration factor X at block 502 and by a blood pump flow constant or calibration factor Y at block 504 before actually being used to control the speed of the anticoagulant pump at block 506 and the blood pump at 508. The two pumps then act upon the closed fluid vessel system (including air) as depicted at block 510 and cause an air pressure response which is measured at block 512. A timed sampler 514 then feeds a gain adjustment control block 516 where the calibration factors X, Y are adjusted relative to one another so as to correct for any noted pump flow rate errors.

Another portion of a typical blood constituent processing system is depicted in FIG. 6. Here the disposable plastic tubing extends on the output side of the blood pump to a plasma filter and on to a pumped packed cell output flow from the filter. In operation, the flow rate of plasma filtrate (e.g., 6 ml/min) may be determined by controlling the pumped rate of blood input (e.g., 50 ml/min) relative to the pumped rate of packed cell output (e.g., 44 ml/min). As in the FIG. 4 embodiment, a branch of tubing between the two pumps includes a volume of trapped air communicating with a pressure transducer. After the system is filled with liquid, the blood pump may be operated near the expected rate of use (or perhaps initially slower) while the plasma filtrate output is clamped shut and the packed cell pump is operated at a nominally equal rate. The pressure P2 will begin to rise or fall due to any difference in actual pump rates. That compliance due to the air pocket in the tubing to the pressure transducer keeps the pressures within reasonable bounds for initial errors in flow rates. Typically, this calibration procedure may be performed after some initial filtration has occurred and blood plasma has already filled the plasma filter and tubing down to the clamp point on the plasma output tube.

FIG. 7 illustrates the resulting pressure profile and its first derivative (with respect to time) for a regularly changing relative difference in pump flow rates. An iterative or other procedure may then be employed (as before) to determine relative pump flow rate calibration factors which may thereafter be used to achieve accurate relative pump flow rates. Following such measurement, the relative flow rates can be temporarily shifted to bring the pressure within a normal range (e.g., as measured just prior to plasma clamp closure) before re-opening the plasma clamp.

As will now be appreciated, if one of the pumps can also be calibrated with respect to an absolute standard (e.g., if the packed cell pump delivers its output to a collection reservior which is carried by an electronic weighing or other volume/mass/weight measuring device), then one can, in turn, use the relative pump flow calibration factors to derive absolute calibration factors for the other pump(s).

If pulsatile pumps are employed, there will, of course, be periodic pressure/volume pulses which may be disregarded (e.g., by employing suitable low pass "averaging" filters) in the calibration procedures.

While only a few exemplary embodiments have been explained in detail, those skilled in the art will recognize that many modifications and variations may be made in these exemplary embodiments while yet maintaining many of the novel features and advantages of this invention. Accordingly, all such modifications and variations are to be included within the scope of the appended claims.

Claims (30)

What is claimed is:
1. A method for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween, said method comprising the steps of:
automatically controlling said pumps to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid pathat respectively associated nominal rates;
automatically measuring changes in at least one fluid flow parameter occurring within said common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and
automatically deriving relative flow calibration data for the individual pumps using said measured changes is obtained.
2. A method as in claim 1 wherein said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate, at least one of said rates being controlled to maintain an approximately constant fluid pressure in said path.
3. A method as in claim 1 wherein said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate, at least one of said rates being controlled to maintain an approximately constant fluid volume in said path.
4. A method as in claim 1 wherein:
said controlling step comprises controlling a first pump to inject fluid into said path at a first nominal rate and controlling a second pump to withdraw fluid from said path at a second nominal rate; and
said measuring step comprises measuring the rate-of-change in fluid pressure in said path.
5. A method for deriving relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the step of:
measuring the relative pump flow controls which are required to maintain an approoxiamtely constant fluid pressure in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.
6. A method for deriving relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the step of:
measuring the relative pump flow controls which are required to maintain an approximately constant fluid volume in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.
7. A method for deriving relative flow calibration data for an anticoagulant pump and a blood pump connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path, said method comprising the steps of:
installing a disposable plastic tubing into a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between an anticoagulant pump and a blood pump;
controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;
measuring a predetermined fluid parameter in said path during said controlling step; and
deriving said relative flow characteristics in response to the controlling and/or measuring steps.
8. A method as in claim 7 wherein said controlling step comprises simultaneously (a) controlling a first pump to inject fluid into said path at a first nominal rate, (b) controlling a second pump to withdraw fluid from said path at a second nominal rate, and (c) changing at least one of said controlled nominal rates so as to maintain an approximately constant measured fluid pressure or volume in said path.
9. A method as in claim 8 wherein said deriving step comprises recording the relationship between the nominal pump flow rates required to maintain said approximately constant fluid pressure.
10. A method as in claim 7 wherein said deriving step comprises measuring the time-based rate of pressure change in said path.
11. A method for obtaining a relative flow calibration factor for a system of plural pumps connected with a common fluid flow path, said method comprising:
controlling at least two of the pumps to simultaneously inject and withdraw fluid from said path at relative rates which approximately maintain a constant fluid pressure or volume within said path; and
measuring at least one relative pump flow calibration factor for said at least two pumps based on the controlled pumping rates required to approximately maintain said constant fluid pressure or volume.
12. A method for calibrating relative pump flow rates of plural pumps connected with a common fluid-containing structure, said method comprising:
controlling at least one of said pumps to pump liquid into said structure at a first nominal rate;
simultaneously controlling at least one other of said pumps to pump liquid out of said structure at a second nominal rate;
monitoring the fluid pressure or volume within said structure during said controlling step; and
adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibration data representing calibrated relative pump flow rates between plural pumps.
13. A method for calibrating a first pump flow with respect to a second pump flow in a blood constituent processing system, said method comprising the steps of:
installing a disposable plastic tubing into said blood constituent processing system which includes a common fluid flow path between said first pump and said second pump;
pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;
detecting changes in fluid pressure or volume within said path caused by said pumping step;
adjusting at least one of said first and second rates in response to said detecting step so as to maintain an approximately constant fluid pressure or volume within said path; and
deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said adjusting step.
14. Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:
means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;
means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into, and withdrawal of fluid from, said common fluid path; and
means for deriving relative flow calibration data for the individual pumps in response to said measured changes.
15. Apparatus as in claim 14 wherein said means for controlling controls a first pump to inject fluid into said path at a first nominal rate and controls a second pump to withdraw fluid from said path at a second nominal rate which is controlled to maintain an approximately constant fluid pressure or volume in said path.
16. Apparatus as in claim 14 wherein:
said means for controlling controls a first pump to inject fluid into said path at a first nominal rate and controls a second pump to withdraw fluid from said path at a second nominal rate; and
said means for measuring measures the rate-of-change in fluid pressure or volume in said path.
17. Apparatus for deriving relative flow calibration data of plural pumps connected with a common closed fluid path, said apparatus comprising:
means for independently controlling plural pumps connected with a common closed flow path; and
means for measuring the relative pump flow controls which are required to maintain an approximately constant fluid pressure or volume in said path while one pump is injecting fluid into said path and another pump is withdrawing fluid from said path.
18. Apparatus for deriving relative flow calibration data of first and second pumps connected in a blood constituent processing system with a disposable plastic tubing which includes a common fluid path between said pumps, said apparatus comprising:
a disposable plastic tubing disposed in a blood constituent processing system and providing a common closed fluid path within the disposable tubing and extending between said first pump and said second pump;
means for controlling the pumps to inject and/or withdraw fluid from said path at respective nominal rates;
means for measuring a predetermined fluid parameter in said path; and
means for deriving said relative flow calibration data in response to the effected pump control and/or the measured parameter.
19. Apparatus as in claim 18 wherein said means for controlling simultaneously (a) controls a first pump to inject fluid into said path at a first nominal rate, (b) controls a second pump to withdraw fluid from said path at a second nominal rate, and (c) changes at least one of said controlled nominal rates in response to said means for measuring so as to maintain an approximately constant measured fluid pressure in said path.
20. Apparatus as in claim 19 wherein said means for deriving records the relationship between the nominal pump flow rates required to maintain said approximately constant fluid pressure.
21. Apparatus as in claim 18 wherein said means for deriving measures the time-based rate of pressure change in said path.
22. Apparatus comprising:
a system of plural pumps connected with a common fluid flow path;
means for controlling at least two of the pumps to simultaneously inject and withdraw fluid from said path at relative rates which approximately maintain a constant fluid pressure or volume within said path; and
means for measuring at least one relative pump flow calibration factor for said at least two pumps based on the controlled pumping rates required to approximately maintain said constant fluid pressure or volume.
23. Apparatus comprising:
plural pumps connected with a common fluid-containing volume;
means for controlling at least one of said pumps to pump liquid into said volume at a first nominal rate;
means for simultaneously controlling at least one other of said pumps to pump liquid out of said volume at a second nominal rate;
means for monitoring the fluid pressure or volume within said volume during said controlling step; and
means for adjusting at least one of said nominal pump rates in response to said monitored fluid pressure or volume so as to obtain calibrated relative pump flow rates between plural pumps.
24. Apparatus for calibrating, during a preliminary set-up period, anticoagulant pump flow with respect to blood pump flow in a blood constituent processing system, said apparatus comprising:
disposable plastic tubing located in a blood constituent process system which includes a closed fluid flow path between an anticoagulant pump connected to a source of anticoagulant solution and a blood pump connected to a source of saline solution;
means for pumping fluid into said path with one of said pumps at a first predetermined nominal rate and pumping fluid out of said path with the other of said pumps at a second predetermined nominal rate, which rates are initially set to be at assumed equal values;
means for detecting changes in fluid pressure within said path caused by said pumping;
means for adjusting at least one of said first and second rates in response to said detected changes so as to maintain an approximately constant fluid pressure within said path; and
means for deriving a relative pump flow calibration factor based on the controlled nominal flow rates required by said means for adjusting.
25. A method for automatically deriving relative flow calibration data for plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:
establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
automaticallly controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path at respectively associated nominal pumping rates;
automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and
automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.
26. A method of operating a fluid system of the type having plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said method comprising:
(a) deriving relative flow calibration data for said plural pumps by:
(i) establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
(ii) automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to wtihdraw fluid from said common fluid path at respectively associated nominal pumping rates;
(iii) automatically measuring changes in at least one fluid flow parameter occuring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rate; and
(iv) automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes; and then
(b) reestablishing, during a normal operating cycle after said preliminary set-up period, said normally open fluid path and controlling the operating rates of said plural pumps based upon said derived relative flow calibration data.
27. Apparatus for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween and a normally open fluid path which establishes fluid communication between the common fluid path and a fluid source, said apparatus comprising:
means for establishing a closed fluid path which includes said common fluid path by terminating, during a preliminary set-up period, fluid communication between said common fluid path and said fluid source;
means for automatically controlling said pumps, during said preliminary set-up period, to inject fluid into said common fluid path and/or to withdraw fluid from said common fluid path ar respectively associated nominal pumping rates;
means for automatically measuring changes in at least one fluid flow parameter occurring within said closed common fluid path in response to said controlling of said pumps at said respectively associated nominal rates; and
means for automatically deriving said relative flow calibration data for the individual pumps in response to said measured changes.
28. A method for automatically deriving relative flow calibration data of plural pumps connected with a common fluid path therebetween, said method comprising the steps of:
automatically controlling said pumps to inject fluid into said common fluid path and/or to withdraw from said common fluid path at respectively associated nominal pumping rates;
automatically measuring changes in at least one fluid flow parameter occurring within said common fluid path in response to said controlling step of said pumps at said respectively associated nominal rates;
comparing said measured changes in said at least one flow parameter to a predetermined standard value for said flow parameter;
automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value; and
automatically deriving relative calibration data representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.
29. A method for deriving a relative flow calibration data for plural pumps connected with a common fluid path, said method comprising the steps of:
(a) operating said pumps at respective nominal pumping rate such that one pump injects fluid into said path and another pump withdraws fluid from said path;
(b) measuring changes of at least one fluid flow parameter occurring within said common fluid path during said operation of said pumps at said respective nominal pumping rates and determining whether said measured changes are within a predetermined value which is required to maintain an approximately constant fluid pressure in said path while said one pump is injecting fluid into said path and said another pump is withdrawing fluid from said path;
(c) modifying the pumping rate of said one and/or another pumps from said nominal pumping rate thereof until said changes of said at least one fluid flow parameter meausured according to step (b) is within said predetermined value; and
(d) deriving a calibration value for said one and/or another pumps which is representative of said modified pumping rate, whereby calibration data for said pumps is obtained.
30. Apparatus for deriving relative flow calibration data for plural pumps connected with a common fluid path, said apparatus comprising:
means for controlling said pumps to inject fluid into said path and/or to withdraw fluid from said path at respectively associated nominal rates;
means for measuring changes in at least one fluid flow parameter occuring within said path in response to said injection of fluid into and withdrawal of fluid from said common fluid path; and
means for deriving relative flow calibration data for the individual pumps, said means for deriving including;
(i) means for comparing said measured changes in said at least one flow paratmeter to a predetermined standard value for said flow parameter;
(ii) means for automatically continually modifying the pumping rate of at least one of said pumps from said nominal pumping rate thereof in response to said measured changes being at variance with said predetermined standard value until said measured changes are comparable to said predetermined standard value; and
(iii) means for generating a calibration value representative of said modified pumping rate of said at least one pump relative to said respective nominal rate thereof, whereby calibration data for the individual pumps using said measured changes is obtained.
US06802330 1987-02-25 1985-11-27 Method and apparatus for calibrating plural pump fluid flow system Expired - Lifetime US4769001A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US1987/000354 WO1988006466A1 (en) 1987-02-25 1987-02-25 Calibrating plural pump fluid flow system

Publications (1)

Publication Number Publication Date
US4769001A true US4769001A (en) 1988-09-06

Family

ID=22202291

Family Applications (1)

Application Number Title Priority Date Filing Date
US06802330 Expired - Lifetime US4769001A (en) 1987-02-25 1985-11-27 Method and apparatus for calibrating plural pump fluid flow system

Country Status (5)

Country Link
US (1) US4769001A (en)
EP (2) EP0302861B1 (en)
JP (1) JP2847161B2 (en)
DE (4) DE3752055T2 (en)
WO (1) WO1988006466A1 (en)

Cited By (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344842A1 (en) * 1988-06-01 1989-12-06 Akzo N.V. Apparatus for withdrawing an optimum amount of blood per unit of time from a donor
GB2225954A (en) * 1988-11-03 1990-06-20 Fresenius Ag Apparatus for infusion of medicaments into an extracorporeal blood circuit
US4998914A (en) * 1988-02-17 1991-03-12 Peter P. Wiest Procedure for the perfusion of cavities in objects and device for executing the procedure
US5004459A (en) * 1984-07-09 1991-04-02 Peabody Alan M Continuous cyclic peritoneal dialysis system and method
WO1992003180A1 (en) * 1990-08-27 1992-03-05 Cryo-Cell International, Inc. Method and apparatus for extracting fluid and related method and apparatus for preserving blood fluid
US5098387A (en) * 1989-10-07 1992-03-24 Peter P. Wiest Device for irrigation of and aspiration from body cavities
US5098384A (en) * 1991-01-23 1992-03-24 Abrams Lawrence M Pressure-compensated fluid administering apparatus
EP0486675A1 (en) * 1990-06-14 1992-05-27 Baxter Int Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple blood components.
EP0486681A1 (en) * 1990-06-14 1992-05-27 Baxter Int Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator.
US5141501A (en) * 1990-05-21 1992-08-25 Vernay Laboratories, Inc. Suction metering and mixing device
US5154700A (en) * 1990-08-13 1992-10-13 Danby Medical Limited Arrangement for monitoring fluid flow during intravenous supply to a patient
US5163926A (en) * 1990-05-21 1992-11-17 Vernay Laboratories, Inc. Suction metering and mixing device
US5195967A (en) * 1992-02-18 1993-03-23 Nakao Naomi L Anticlotting device and method for use with IV catheters
US5322500A (en) * 1991-05-09 1994-06-21 Cardio Pulmonary Supplies, Inc. Variable ratio blood-additive solution device and delivery system
US5378227A (en) * 1992-08-11 1995-01-03 Cobe Laboratories, Inc. Biological/pharmaceutical method and apparatus for collecting and mixing fluids
US5421812A (en) * 1992-03-04 1995-06-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in tubing system
US5490765A (en) * 1993-05-17 1996-02-13 Cybor Corporation Dual stage pump system with pre-stressed diaphragms and reservoir
US5527161A (en) * 1992-02-13 1996-06-18 Cybor Corporation Filtering and dispensing system
US5608650A (en) * 1994-08-19 1997-03-04 Spectrel Partners, L.L.C. Systems and methods for testing pump flow rates
US5639382A (en) * 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
US5676841A (en) * 1991-12-23 1997-10-14 Baxter International Inc. Blood processing systems and methods which monitor citrate return to the donor
US5676645A (en) * 1992-03-04 1997-10-14 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in vivos and in tubing systems
US5681273A (en) * 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
US5691478A (en) * 1995-06-07 1997-11-25 Schneider/Namic Device and method for remote zeroing of a biological fluid pressure measurement device
US5690835A (en) 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5697899A (en) * 1995-02-07 1997-12-16 Gensia Feedback controlled drug delivery system
US5717603A (en) * 1994-08-19 1998-02-10 Spectrel Partners, L.L.C. Integrated test station for testing liquid flow and electrical safety characteristics of IV pumps
US5730883A (en) * 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
EP0831946A2 (en) * 1995-02-07 1998-04-01 Gensia, Inc. Feedback controlled drug delivery system
US5742519A (en) * 1994-08-19 1998-04-21 Spectrel Partners, L.L.C. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US5759413A (en) * 1995-06-07 1998-06-02 Baxter International Inc. Systems and method for estimating platelet counts using a spleen mobilization function
US5762791A (en) * 1995-08-09 1998-06-09 Baxter International Inc. Systems for separating high hematocrit red blood cell concentrations
US5817042A (en) * 1992-03-04 1998-10-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in vivos and in tubing systems
US5833866A (en) * 1991-12-23 1998-11-10 Baxter International Inc. Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
US5927349A (en) * 1996-12-09 1999-07-27 Baxter International Inc. Compounding assembly for nutritional fluids
US5965089A (en) * 1996-10-04 1999-10-12 United States Surgical Corporation Circulatory support system
US5984893A (en) * 1997-03-27 1999-11-16 Ward; Roger T. Blood infusion control system
US6007725A (en) 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US6164920A (en) * 1996-09-30 2000-12-26 Minnesota Mining And Manufacturing Company Perfusion system with control network
US6199603B1 (en) 1998-08-14 2001-03-13 Baxter International Inc. Compounding assembly for nutritional fluids
US6251284B1 (en) 1995-08-09 2001-06-26 Baxter International Inc. Systems and methods which obtain a uniform targeted volume of concentrated red blood cells in diverse donor populations
US20010013822A1 (en) * 1996-09-30 2001-08-16 Richard A. Nazarian Medical perfusion system
US20020183585A1 (en) * 1996-09-30 2002-12-05 Terumo Cardiovascular Systems Corporation Network communication and message protocol for a medical perfusion system
US6527957B1 (en) 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US20030097232A1 (en) * 1994-08-19 2003-05-22 Triad Infusion Products, Inc. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US6691047B1 (en) 2000-03-16 2004-02-10 Aksys, Ltd. Calibration of pumps, such as blood pumps of dialysis machine
US20040186414A1 (en) * 2003-02-03 2004-09-23 Maurice Behague Collection bag system with preformed loop
US20050145009A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. Empty container detection using container side pressure sensing
US20050145008A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. System for detecting the status of a vent associated with a fluid supply upstream of an infusion pump
US20050145010A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. Medication safety enhancement for secondary infusion
US20050230328A1 (en) * 2004-04-16 2005-10-20 Kyungyoon Min Methods for determining flow rates of biological fluids
US20070243990A1 (en) * 2006-04-18 2007-10-18 Gambro, Inc. Extracorporeal Blood Processing Apparatus with Pump Balancing
US20090035845A1 (en) * 2004-12-01 2009-02-05 National University Of Singapore Method and device for extracting and/or collecting blood from placenta and/or umbilical cord
US20090060753A1 (en) * 2007-08-27 2009-03-05 Jones Kenneth A Self-Adaptive Piston Blood Pump
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US8016745B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. Monitoring of a food intake restriction device
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
WO2014007742A1 (en) * 2012-07-05 2014-01-09 Stroemberg Lennart Blood collection system and method
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
WO2015007596A1 (en) 2013-07-15 2015-01-22 Gambro Lundia Ab Relative pump calibration for ultrafiltration control in a dialysis apparatus
WO2015007595A1 (en) 2013-07-15 2015-01-22 Gambro Lundia Ab Individual pump calibration for ultrafiltration control in a dialysis apparatus
WO2016057982A1 (en) * 2014-10-10 2016-04-14 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
EP3031485A1 (en) * 2014-12-10 2016-06-15 B. Braun Avitum AG Method and control apparatus for determining and adjusting a flow rate of a blood delivery pump
US9603989B2 (en) 2010-08-24 2017-03-28 Fenwal, Inc. Methods for anticoagulating blood

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3806248C2 (en) * 1988-02-27 1991-07-11 Fresenius Ag, 6380 Bad Homburg, De
US5752931A (en) * 1996-09-30 1998-05-19 Minnesota Mining And Manufacturing Company Perfusion system with perfusion circuit display
WO2000009182A1 (en) 1998-08-11 2000-02-24 Alpamed S.A. Fluid driving device
JP4853956B2 (en) * 2006-04-05 2012-01-11 日機装株式会社 Priming method of the blood circuit
EP2343092B2 (en) 2009-12-22 2016-07-13 Gambro Lundia AB Method and apparatus for controlling a fluid flow rate in a fluid transport line of a medical device

Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817658A (en) * 1971-03-22 1974-06-18 Tokyo Heat Treating Fluid control apparatus
US4086924A (en) * 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4197847A (en) * 1977-03-31 1980-04-15 Isaac Djerassi Method and apparatus for collecting transfusable granulocytes
US4280494A (en) * 1979-06-26 1981-07-28 Cosgrove Robert J Jun System for automatic feedback-controlled administration of drugs
US4285464A (en) * 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4303193A (en) * 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4379452A (en) * 1977-10-18 1983-04-12 Baxter Travenol Laboratories, Inc. Prepackaged, self-contained fluid circuit module
US4392849A (en) * 1981-07-27 1983-07-12 The Cleveland Clinic Foundation Infusion pump controller
US4416654A (en) * 1981-09-03 1983-11-22 Haemonetics Corporation Pheresis apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4468219A (en) * 1983-12-20 1984-08-28 International Business Machines Corporation Pump flow rate compensation system
US4481827A (en) * 1981-12-15 1984-11-13 Baxter Travenol Laboratories, Inc. Blood fractionation apparatus having collection rate display system
US4493693A (en) * 1982-07-30 1985-01-15 Baxter Travenol Laboratories, Inc. Trans-membrane pressure monitoring system
US4498983A (en) * 1983-05-26 1985-02-12 Baxter Travenol Laboratories, Inc. Pressure cuff draw mode enhancement system and method for a single needle blood fractionation system
US4526515A (en) * 1979-12-06 1985-07-02 Baxter Travenol Laboratories, Inc. Fluid pumping assembly including a prepackaged fluid circuit module
US4563173A (en) * 1983-04-19 1986-01-07 National Biomedical Research Foundation Pump-actuated sequencing valve and system
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
US4648866A (en) * 1983-07-07 1987-03-10 Rhone-Poulenc S.A. Process/apparatus for the withdrawal/return of body fluids
US4657529A (en) * 1984-06-29 1987-04-14 Hemascience Laboratories, Inc. Blood extraction and reinfusion flow control system and method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3439661C2 (en) * 1984-10-30 1988-04-14 Fresenius Ag, 6380 Bad Homburg, De
FR2581316A1 (en) * 1985-05-02 1986-11-07 Murisasco Antoine Method and device for automatic plasma exchanges controlled by an integrated computer

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817658A (en) * 1971-03-22 1974-06-18 Tokyo Heat Treating Fluid control apparatus
US4086924A (en) * 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4197847A (en) * 1977-03-31 1980-04-15 Isaac Djerassi Method and apparatus for collecting transfusable granulocytes
US4379452A (en) * 1977-10-18 1983-04-12 Baxter Travenol Laboratories, Inc. Prepackaged, self-contained fluid circuit module
US4285464A (en) * 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4303193A (en) * 1979-01-22 1981-12-01 Haemonetics Corporation Apparatus for separating blood into components thereof
US4280494A (en) * 1979-06-26 1981-07-28 Cosgrove Robert J Jun System for automatic feedback-controlled administration of drugs
US4526515A (en) * 1979-12-06 1985-07-02 Baxter Travenol Laboratories, Inc. Fluid pumping assembly including a prepackaged fluid circuit module
US4392849A (en) * 1981-07-27 1983-07-12 The Cleveland Clinic Foundation Infusion pump controller
US4416654A (en) * 1981-09-03 1983-11-22 Haemonetics Corporation Pheresis apparatus
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4481827A (en) * 1981-12-15 1984-11-13 Baxter Travenol Laboratories, Inc. Blood fractionation apparatus having collection rate display system
US4493693A (en) * 1982-07-30 1985-01-15 Baxter Travenol Laboratories, Inc. Trans-membrane pressure monitoring system
US4563173A (en) * 1983-04-19 1986-01-07 National Biomedical Research Foundation Pump-actuated sequencing valve and system
US4498983A (en) * 1983-05-26 1985-02-12 Baxter Travenol Laboratories, Inc. Pressure cuff draw mode enhancement system and method for a single needle blood fractionation system
US4605503A (en) * 1983-05-26 1986-08-12 Baxter Travenol Laboratories, Inc. Single needle blood fractionation system having adjustable recirculation through filter
US4648866A (en) * 1983-07-07 1987-03-10 Rhone-Poulenc S.A. Process/apparatus for the withdrawal/return of body fluids
US4468219A (en) * 1983-12-20 1984-08-28 International Business Machines Corporation Pump flow rate compensation system
US4657529A (en) * 1984-06-29 1987-04-14 Hemascience Laboratories, Inc. Blood extraction and reinfusion flow control system and method

Cited By (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004459A (en) * 1984-07-09 1991-04-02 Peabody Alan M Continuous cyclic peritoneal dialysis system and method
US4998914A (en) * 1988-02-17 1991-03-12 Peter P. Wiest Procedure for the perfusion of cavities in objects and device for executing the procedure
EP0344842A1 (en) * 1988-06-01 1989-12-06 Akzo N.V. Apparatus for withdrawing an optimum amount of blood per unit of time from a donor
US5045057A (en) * 1988-06-01 1991-09-03 Akzo Nv Apparatus and method for withdrawing an optimum amount of blood per unit of time from a donor
GB2225954B (en) * 1988-11-03 1992-06-17 Fresenius Ag Apparatus for infusion of medicaments into an extracorporeal blood circuit
GB2225954A (en) * 1988-11-03 1990-06-20 Fresenius Ag Apparatus for infusion of medicaments into an extracorporeal blood circuit
US5098387A (en) * 1989-10-07 1992-03-24 Peter P. Wiest Device for irrigation of and aspiration from body cavities
US5141501A (en) * 1990-05-21 1992-08-25 Vernay Laboratories, Inc. Suction metering and mixing device
US5163926A (en) * 1990-05-21 1992-11-17 Vernay Laboratories, Inc. Suction metering and mixing device
EP0486675A1 (en) * 1990-06-14 1992-05-27 Baxter Int Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple blood components.
EP0968731A1 (en) * 1990-06-14 2000-01-05 Baxter International Inc. Method of separating a blood component from whole blood
EP0664135A1 (en) * 1990-06-14 1995-07-26 Baxter International Inc. Method of separating a blood component from whole blood
EP0486675A4 (en) * 1990-06-14 1993-01-27 Baxter International Inc. Automated blood component separation procedure and apparatus promoting different functional characteristics in multiple blood components
EP0486681A1 (en) * 1990-06-14 1992-05-27 Baxter Int Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator.
EP0661064A1 (en) * 1990-06-14 1995-07-05 Baxter International Inc. Method and apparatus for separating platelets from whole blood
EP0486681A4 (en) * 1990-06-14 1993-01-27 Baxter International Inc. Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator
US5154700A (en) * 1990-08-13 1992-10-13 Danby Medical Limited Arrangement for monitoring fluid flow during intravenous supply to a patient
US5114672A (en) * 1990-08-27 1992-05-19 Cryo-Cell International, Inc. Method for preserving blood fluid
WO1992003180A1 (en) * 1990-08-27 1992-03-05 Cryo-Cell International, Inc. Method and apparatus for extracting fluid and related method and apparatus for preserving blood fluid
WO1992012742A1 (en) * 1991-01-23 1992-08-06 Abrams Lawrence M Pressure-compensated fluid administering apparatus
US5098384A (en) * 1991-01-23 1992-03-24 Abrams Lawrence M Pressure-compensated fluid administering apparatus
US5322500A (en) * 1991-05-09 1994-06-21 Cardio Pulmonary Supplies, Inc. Variable ratio blood-additive solution device and delivery system
US6207063B1 (en) 1991-12-23 2001-03-27 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US5833866A (en) * 1991-12-23 1998-11-10 Baxter International Inc. Blood collection systems and methods which derive instantaneous blood component yield information during blood processing
US5690835A (en) 1991-12-23 1997-11-25 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5639382A (en) * 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
US5681273A (en) * 1991-12-23 1997-10-28 Baxter International Inc. Systems and methods for predicting blood processing parameters
US5676841A (en) * 1991-12-23 1997-10-14 Baxter International Inc. Blood processing systems and methods which monitor citrate return to the donor
US6007725A (en) 1991-12-23 1999-12-28 Baxter International Inc. Systems and methods for on line collection of cellular blood components that assure donor comfort
US5730883A (en) * 1991-12-23 1998-03-24 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US6059979A (en) * 1991-12-23 2000-05-09 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process control parameter
US5527161A (en) * 1992-02-13 1996-06-18 Cybor Corporation Filtering and dispensing system
US5336181A (en) * 1992-02-18 1994-08-09 Nakao Naomi L Anticlotting device and method for use with IV catheters
WO1993015780A1 (en) * 1992-02-18 1993-08-19 Nakao Naomi L Anticlotting device and method for iv catheters
US5195967A (en) * 1992-02-18 1993-03-23 Nakao Naomi L Anticlotting device and method for use with IV catheters
US5676645A (en) * 1992-03-04 1997-10-14 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in vivos and in tubing systems
US5817042A (en) * 1992-03-04 1998-10-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in vivos and in tubing systems
US5421812A (en) * 1992-03-04 1995-06-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in tubing system
US5378227A (en) * 1992-08-11 1995-01-03 Cobe Laboratories, Inc. Biological/pharmaceutical method and apparatus for collecting and mixing fluids
US5665061A (en) * 1992-08-11 1997-09-09 Cobe Laboratories, Inc. Biological/pharmaceutical method and apparatus for collecting and mixing fluids
US5490765A (en) * 1993-05-17 1996-02-13 Cybor Corporation Dual stage pump system with pre-stressed diaphragms and reservoir
US20030097232A1 (en) * 1994-08-19 2003-05-22 Triad Infusion Products, Inc. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US5856929A (en) * 1994-08-19 1999-01-05 Spectrel Partners, L.L.C. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US5608650A (en) * 1994-08-19 1997-03-04 Spectrel Partners, L.L.C. Systems and methods for testing pump flow rates
US5717603A (en) * 1994-08-19 1998-02-10 Spectrel Partners, L.L.C. Integrated test station for testing liquid flow and electrical safety characteristics of IV pumps
US5742519A (en) * 1994-08-19 1998-04-21 Spectrel Partners, L.L.C. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US6757630B2 (en) 1994-08-19 2004-06-29 Mediq/Prn Life Support Services, Inc. Integrated systems for testing and certifying the physical, functional, and electrical performance of IV pumps
US5697899A (en) * 1995-02-07 1997-12-16 Gensia Feedback controlled drug delivery system
EP0831946A2 (en) * 1995-02-07 1998-04-01 Gensia, Inc. Feedback controlled drug delivery system
EP0831946A4 (en) * 1995-02-07 1999-09-22 Gensia Inc Feedback controlled drug delivery system
US6197202B1 (en) 1995-06-07 2001-03-06 Baxter International Inc. Systems and methods for estimating platelet counts using a spleen mobilization function
US6451203B2 (en) 1995-06-07 2002-09-17 Baxter International Inc. Blood processing systems and methods using apparent hematocrit as a process of control parameter
US5759413A (en) * 1995-06-07 1998-06-02 Baxter International Inc. Systems and method for estimating platelet counts using a spleen mobilization function
US6802982B2 (en) 1995-06-07 2004-10-12 Baxter International Inc. Blood processing systems and methods using red blood cell hematocrit as a process control parameter
US5691478A (en) * 1995-06-07 1997-11-25 Schneider/Namic Device and method for remote zeroing of a biological fluid pressure measurement device
US6080322A (en) * 1995-08-09 2000-06-27 Baxter International Inc. Systems and methods for separating high hematocrit red blood cell concentrations
US5762791A (en) * 1995-08-09 1998-06-09 Baxter International Inc. Systems for separating high hematocrit red blood cell concentrations
US6251284B1 (en) 1995-08-09 2001-06-26 Baxter International Inc. Systems and methods which obtain a uniform targeted volume of concentrated red blood cells in diverse donor populations
US6527957B1 (en) 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US6164920A (en) * 1996-09-30 2000-12-26 Minnesota Mining And Manufacturing Company Perfusion system with control network
US20090163854A1 (en) * 1996-09-30 2009-06-25 Terumo Cardiovascular Systems Corporation Network Communication and Message Protocol for a Medical Perfusion System
US20010013822A1 (en) * 1996-09-30 2001-08-16 Richard A. Nazarian Medical perfusion system
US7535336B2 (en) 1996-09-30 2009-05-19 Terumo Cardiovascular Systems Corporation Network communication and message protocol for a medical perfusion system
US20020183585A1 (en) * 1996-09-30 2002-12-05 Terumo Cardiovascular Systems Corporation Network communication and message protocol for a medical perfusion system
US20060290464A1 (en) * 1996-09-30 2006-12-28 Willems Richard M Network communication and message protocol for a medical perfusion system
US7843311B2 (en) 1996-09-30 2010-11-30 Terumo Cardiovascular Systems Network communication and message protocol for a medical perfusion system
US7148786B2 (en) 1996-09-30 2006-12-12 Terumo Cardiovascular Systems Corporation Network communication and message protocol for a medical perfusion system
US7006005B2 (en) 1996-09-30 2006-02-28 Terumo Cardiovascular Systems Adapter pod for use in medical perfusion system
US7264606B2 (en) 1996-10-04 2007-09-04 United States Surgical Corporation Circulatory support system
US20040191116A1 (en) * 1996-10-04 2004-09-30 Robert Jarvik Circulatory support system
US5965089A (en) * 1996-10-04 1999-10-12 United States Surgical Corporation Circulatory support system
US5927349A (en) * 1996-12-09 1999-07-27 Baxter International Inc. Compounding assembly for nutritional fluids
US6202711B1 (en) 1996-12-09 2001-03-20 Baxter International Inc. Compounding assembly for nutritional fluids
US5984893A (en) * 1997-03-27 1999-11-16 Ward; Roger T. Blood infusion control system
US6199603B1 (en) 1998-08-14 2001-03-13 Baxter International Inc. Compounding assembly for nutritional fluids
US6691047B1 (en) 2000-03-16 2004-02-10 Aksys, Ltd. Calibration of pumps, such as blood pumps of dialysis machine
WO2003072160A3 (en) * 2002-02-21 2004-07-22 Terumo Cardiovascular Sys Network communication and message protocol for a medical perfusion system
WO2003072160A2 (en) * 2002-02-21 2003-09-04 Terumo Cardiovascular Systems Corporation Network communication and message protocol for a medical perfusion system
US7503901B2 (en) * 2003-02-03 2009-03-17 Macopharma Collection bag system with preformed loop
US20040186414A1 (en) * 2003-02-03 2004-09-23 Maurice Behague Collection bag system with preformed loop
US7255683B2 (en) 2003-12-31 2007-08-14 Cardinal Health 303, Inc. System for detecting the status of a vent associated with a fluid supply upstream of an infusion pump
US7206715B2 (en) 2003-12-31 2007-04-17 Cardinal Health 303, Inc. Empty container detection using container side pressure sensing
US20050145010A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. Medication safety enhancement for secondary infusion
US20050145008A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. System for detecting the status of a vent associated with a fluid supply upstream of an infusion pump
US9039656B2 (en) 2003-12-31 2015-05-26 Carefusion 303, Inc. Medication safety enhancement for secondary infusion
US20070271062A1 (en) * 2003-12-31 2007-11-22 Vanderveen Timothy W Empty container detection using container side pressure sensing
US20070274843A1 (en) * 2003-12-31 2007-11-29 Cardinal Health 303, Inc. System for detecting the status of a vent associated with a fluid supply upstream of an infusion pump
US20050145009A1 (en) * 2003-12-31 2005-07-07 Vanderveen Timothy W. Empty container detection using container side pressure sensing
US8672875B2 (en) 2003-12-31 2014-03-18 Carefusion 303, Inc. Medication safety enhancement for secondary infusion
US7561986B2 (en) 2003-12-31 2009-07-14 Cardinal Health 303, Inc. Empty container detection using container side pressure sensing
US7396452B2 (en) 2004-04-16 2008-07-08 Fenwal, Inc. Apparatus for determining flow rates of biological fluids
US20050230328A1 (en) * 2004-04-16 2005-10-20 Kyungyoon Min Methods for determining flow rates of biological fluids
US7087177B2 (en) 2004-04-16 2006-08-08 Baxter International Inc. Methods for determining flow rates of biological fluids
US20070000848A1 (en) * 2004-04-16 2007-01-04 Kyungyoon Min Apparatus for determining flow rates of biological fluids
US20090035845A1 (en) * 2004-12-01 2009-02-05 National University Of Singapore Method and device for extracting and/or collecting blood from placenta and/or umbilical cord
US8486034B2 (en) * 2004-12-01 2013-07-16 National University Of Singapore Method and device for extracting and/or collecting blood from placenta and/or umbilical cord
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US8016745B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. Monitoring of a food intake restriction device
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US20070243990A1 (en) * 2006-04-18 2007-10-18 Gambro, Inc. Extracorporeal Blood Processing Apparatus with Pump Balancing
US7556611B2 (en) * 2006-04-18 2009-07-07 Caridianbct, Inc. Extracorporeal blood processing apparatus with pump balancing
US20090060753A1 (en) * 2007-08-27 2009-03-05 Jones Kenneth A Self-Adaptive Piston Blood Pump
US8475138B2 (en) 2007-08-27 2013-07-02 Quest Medical, Inc. Self-adaptive piston blood pump
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US9603989B2 (en) 2010-08-24 2017-03-28 Fenwal, Inc. Methods for anticoagulating blood
US10058645B2 (en) 2010-08-24 2018-08-28 Fenwal, Inc. Systems for anticoagulating blood
US9579444B2 (en) 2012-07-05 2017-02-28 LenJam AB Blood collection system and method
WO2014007742A1 (en) * 2012-07-05 2014-01-09 Stroemberg Lennart Blood collection system and method
CN104470554A (en) * 2013-07-15 2015-03-25 甘布罗伦迪亚股份公司 Relative pump calibration for ultrafiltration control in a dialysis apparatus
WO2015007595A1 (en) 2013-07-15 2015-01-22 Gambro Lundia Ab Individual pump calibration for ultrafiltration control in a dialysis apparatus
US9962476B2 (en) 2013-07-15 2018-05-08 Gambro Lundia Ab Individual pump calibration for ultrafiltration control in a dialysis apparatus
CN104470554B (en) * 2013-07-15 2017-03-08 甘布罗伦迪亚股份公司 For calibrating relative pump control ultrafiltration dialysis apparatus
WO2015007596A1 (en) 2013-07-15 2015-01-22 Gambro Lundia Ab Relative pump calibration for ultrafiltration control in a dialysis apparatus
WO2016057982A1 (en) * 2014-10-10 2016-04-14 Nxstage Medical, Inc. Flow balancing devices, methods, and systems
EP3031485A1 (en) * 2014-12-10 2016-06-15 B. Braun Avitum AG Method and control apparatus for determining and adjusting a flow rate of a blood delivery pump

Also Published As

Publication number Publication date Type
EP0578338A2 (en) 1994-01-12 application
EP0578338B1 (en) 1997-04-23 grant
JPH01503198A (en) 1989-11-02 application
EP0578338A3 (en) 1994-03-02 application
EP0302861B1 (en) 1995-12-27 grant
WO1988006466A1 (en) 1988-09-07 application
EP0302861A4 (en) 1990-04-10 application
DE3752055D1 (en) 1997-05-28 grant
JP2847161B2 (en) 1999-01-13 grant
EP0302861A1 (en) 1989-02-15 application
DE3751656D1 (en) 1996-02-08 grant
DE3752055T2 (en) 1997-11-20 grant
DE3751656T2 (en) 1996-09-05 grant

Similar Documents

Publication Publication Date Title
US6251295B1 (en) Method for recirculation washing of blood cells
US4728433A (en) Ultrafiltration regulation by differential weighing
US4747950A (en) Method and apparatus for controlled ultrafiltration during hemodialysis
US4850998A (en) Method for wetting a plasmapheresis filter with anticoagulant
US6730233B2 (en) Device and method for controlling infusion of liquid in an extracorporeal blood circuit
US7004924B1 (en) Methods, systems, and kits for the extracorporeal processing of blood
US5954971A (en) Pumped-filter blood-processing apparatus and methods
US5776345A (en) Automatic priming technique
US6280632B1 (en) Device and method for preparation of substitution solution
US4827430A (en) Flow measurement system
US6044691A (en) Blood tubing set integrity tests for extracorporeal circuits
US20060064053A1 (en) Multichannel coordinated infusion system
US4606826A (en) Apparatus for controlling ultrafiltration and method for the same
US20060226079A1 (en) Hemodialysis apparatus and method for hemodialysis
US20030055375A1 (en) Method for compensating for pressure differences across valves in cassette type IV pump
EP0052004A1 (en) System and method for controlling and monitoring blood or biologic fluid flow
US6691047B1 (en) Calibration of pumps, such as blood pumps of dialysis machine
US3939069A (en) Artificial kidney and a method of ultrafiltering a liquid
US5213573A (en) Iv administration set infiltration monitor
US6767333B1 (en) Safety device for a blood treatment machine and a method of increasing the safety of a blood treatment machine
EP0547025A1 (en) Method for determining a concentration of a substance in blood or the dialysance of a dialyser
US4275726A (en) Apparatus for fluid balancing under sterile conditions
US20100280430A1 (en) Infusion apparatus
US5087245A (en) System and method for detecting abnormalities in intravascular infusion
US4708802A (en) Apparatus for hemodiafiltration

Legal Events

Date Code Title Description
AS Assignment

Owner name: HEMASCIENCE LABORATORIES, INC., 2807 CATHERINE WAY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:PRINCE, PAUL R.;REEL/FRAME:004488/0907

Effective date: 19851126

AS Assignment

Owner name: BAXTER INTERNATIONAL INC.,

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:HEMASCIENCE LABORATORIES, INC.,;REEL/FRAME:004891/0642

Effective date: 19880603

FPAY Fee payment

Year of fee payment: 4

FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12