CA2058872A1 - Recombinant iga protease - Google Patents

Recombinant iga protease

Info

Publication number
CA2058872A1
CA2058872A1 CA2058872A CA2058872A CA2058872A1 CA 2058872 A1 CA2058872 A1 CA 2058872A1 CA 2058872 A CA2058872 A CA 2058872A CA 2058872 A CA2058872 A CA 2058872A CA 2058872 A1 CA2058872 A1 CA 2058872A1
Authority
CA
Canada
Prior art keywords
iga protease
recombinant
recombinant iga
terminal
codes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2058872A
Other languages
French (fr)
Other versions
CA2058872C (en
Inventor
Dorothea Ambrosius
Carola Dony
Rainer Rudolph
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2058872A1 publication Critical patent/CA2058872A1/en
Application granted granted Critical
Publication of CA2058872C publication Critical patent/CA2058872C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

Abstract

The present invention concerns a process for the isolation of recombinant IgA protease from inclusion bodies. In addition a recombinant DNA is claimed which codes for an IgA protease whose C-terminal helper sequence and preferably also its N-terminal signal sequence is no longer active.
CA002058872A 1991-01-11 1992-01-07 Recombinant iga protease Expired - Lifetime CA2058872C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4100704.2 1991-01-11
DE4100704 1991-01-11
DEP4140699.0 1991-12-10
DE4140699A DE4140699A1 (en) 1991-01-11 1991-12-10 RECOMBINANT IGA PROTEASE

Publications (2)

Publication Number Publication Date
CA2058872A1 true CA2058872A1 (en) 1992-07-12
CA2058872C CA2058872C (en) 1999-12-21

Family

ID=25900194

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002058872A Expired - Lifetime CA2058872C (en) 1991-01-11 1992-01-07 Recombinant iga protease

Country Status (14)

Country Link
EP (1) EP0495398B1 (en)
JP (1) JP2509410B2 (en)
AT (1) ATE174627T1 (en)
AU (1) AU636261B2 (en)
CA (1) CA2058872C (en)
DE (2) DE4140699A1 (en)
DK (1) DK0495398T3 (en)
ES (1) ES2127732T3 (en)
FI (1) FI103132B1 (en)
HU (1) HU215188B (en)
IE (1) IE914559A1 (en)
IL (1) IL100623A (en)
NZ (1) NZ241280A (en)
TW (1) TW197470B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383775B1 (en) 1996-09-11 2002-05-07 Interleukin Genetics, Inc. Designer proteases

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3651595A (en) * 1994-09-21 1996-04-09 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Drug for the prevention and treatment of auto-immune and viral diseases, and diagnostic agents for detecting said diseases
AU9260598A (en) * 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Zymogenic protease precursors that can be autocatalytically activated and their use
AU9341398A (en) * 1997-08-22 1999-03-16 Boehringer Mannheim Gmbh Protease precursors that can be autocatalytically activated and their use
WO2001019970A2 (en) * 1999-09-15 2001-03-22 Eli Lilly And Company Chymotrypsin-free trypsin
WO2010118337A2 (en) * 2009-04-10 2010-10-14 Biomarin Pharmaceutical Inc. Methods of enhancing yield of active iga protease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3622221A1 (en) * 1986-07-02 1988-01-14 Max Planck Gesellschaft METHOD FOR THE GENE-TECHNOLOGICAL EXTRACTION OF PROTEINS USING GRAM-NEGATIVE HOST CELLS
DE3832898A1 (en) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh PRAEPARATE OF EXPRESSED PLASMINOGEN ACTIVATOR IN PROKARYONS
DK130889A (en) * 1989-03-17 1990-09-18 Mogens Kilian IMMUNOGLOBULIN A1 PROTEASES (IGA1 PROTASES), PROCEDURES FOR GENTECHNOLOGICAL PREPARATION OF SUCH ENZYMES, AND VACCINE-CONTAINING ENZYMES AND SYMBOLS OF PROMISTS OF BACKGROUND IMMUNISTRY AND BIT

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383775B1 (en) 1996-09-11 2002-05-07 Interleukin Genetics, Inc. Designer proteases

Also Published As

Publication number Publication date
AU636261B2 (en) 1993-04-22
DE59209590D1 (en) 1999-01-28
TW197470B (en) 1993-01-01
HUT63654A (en) 1993-09-28
NZ241280A (en) 1993-10-26
DE4140699A1 (en) 1992-07-16
FI103132B (en) 1999-04-30
DK0495398T3 (en) 1999-08-23
JP2509410B2 (en) 1996-06-19
IE914559A1 (en) 1992-07-15
HU215188B (en) 1998-10-28
AU9011691A (en) 1992-09-10
CA2058872C (en) 1999-12-21
HU9200092D0 (en) 1992-03-30
FI920117A0 (en) 1992-01-10
FI920117A (en) 1992-07-12
JPH05168478A (en) 1993-07-02
FI103132B1 (en) 1999-04-30
EP0495398B1 (en) 1998-12-16
IL100623A (en) 2002-07-25
ATE174627T1 (en) 1999-01-15
ES2127732T3 (en) 1999-05-01
EP0495398A1 (en) 1992-07-22
IL100623A0 (en) 1992-09-06

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry