CA2057734A1 - Alkylester de glutathion du type oxyde - Google Patents
Alkylester de glutathion du type oxydeInfo
- Publication number
- CA2057734A1 CA2057734A1 CA2057734A CA2057734A CA2057734A1 CA 2057734 A1 CA2057734 A1 CA 2057734A1 CA 2057734 A CA2057734 A CA 2057734A CA 2057734 A CA2057734 A CA 2057734A CA 2057734 A1 CA2057734 A1 CA 2057734A1
- Authority
- CA
- Canada
- Prior art keywords
- oxidized
- type glutathione
- alkyl ester
- ester
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Natural products OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title abstract 4
- 108010024636 Glutathione Proteins 0.000 title abstract 3
- 229960003180 glutathione Drugs 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003570 air Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2416855A JP2921124B2 (ja) | 1990-12-28 | 1990-12-28 | 酸化型グルタチオンアルキルエステル |
| JP416855/1990 | 1990-12-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2057734A1 true CA2057734A1 (fr) | 1992-06-29 |
| CA2057734C CA2057734C (fr) | 1997-12-02 |
Family
ID=18525041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002057734A Expired - Fee Related CA2057734C (fr) | 1990-12-28 | 1991-12-16 | Alkylester de glutathion du type oxyde |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5223488A (fr) |
| EP (1) | EP0497001B1 (fr) |
| JP (1) | JP2921124B2 (fr) |
| KR (1) | KR0178794B1 (fr) |
| AT (1) | ATE150764T1 (fr) |
| CA (1) | CA2057734C (fr) |
| DE (1) | DE69125360T2 (fr) |
| ES (1) | ES2099125T3 (fr) |
| RU (1) | RU2043994C1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09124509A (ja) * | 1995-10-27 | 1997-05-13 | Sumitomo Electric Ind Ltd | 肝炎治療剤 |
| ATE214936T1 (de) * | 1995-12-14 | 2002-04-15 | Novelos Therapeutics Inc | Oxidiertes glutathion als mittel zur verbesserung der endogenen produktion von cytokinen und haematopoietischen faktoren |
| US6251857B1 (en) * | 1995-12-14 | 2001-06-26 | Novelos Therapeutics, Inc. | Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof |
| EP1059919A1 (fr) * | 1998-02-24 | 2000-12-20 | Dovetail Technologies, Inc. | Petites molecules favorisant la prise ponderale a partir d'aliments |
| US20070142267A1 (en) | 1998-11-23 | 2007-06-21 | Novelos Therapeutics, Inc. | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells |
| RU2144374C1 (ru) * | 1998-11-23 | 2000-01-20 | Закрытое акционерное общество "ВАМ" | Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток |
| US7172905B2 (en) | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
| AU2003247907A1 (en) * | 2002-07-05 | 2004-01-23 | University Of Chicago | Characterization of biochips containing self-assembled monolayers with maldi-tof-ms |
| US7080671B2 (en) * | 2002-12-17 | 2006-07-25 | Paraphase, Inc. | Replacement vehicle fuel intake device |
| US6941707B2 (en) * | 2003-05-02 | 2005-09-13 | Certainteed Corporation | Vented soffit panel |
| US20110064828A1 (en) * | 2009-09-11 | 2011-03-17 | Novelos Therapeutics, Incorporated | Treatment of metastatic tumors and other conditions |
| US20130245198A1 (en) | 2012-03-14 | 2013-09-19 | Ralf Mruk | Pneumatic tire |
| US20130245199A1 (en) | 2012-03-14 | 2013-09-19 | Ralf Mruk | Functionalized elastomer |
| RU2692065C1 (ru) * | 2018-04-05 | 2019-06-20 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Глутатионаммониевые соли o,o-диорганилдитиофосфорных кислот, обладающие антиоксидантной и противоопухолевой активностью |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879370A (en) * | 1983-12-02 | 1989-11-07 | Cornell Research Foundation, Inc. | Glutathione delivery system |
| FR2579461B1 (fr) * | 1985-03-28 | 1988-08-26 | Strasbourg Universite L Pasteu | Amides de l'acide para-methoxycinnamique et de l'acide urocanique utilises comme filtres solaires; procedes d'obtention, compositions dermo-pharmaceutiques et cosmetiques les contenant et applications |
| JPH075631B2 (ja) * | 1986-03-19 | 1995-01-25 | 参天製薬株式会社 | グルタチオン誘導体 |
-
1990
- 1990-12-28 JP JP2416855A patent/JP2921124B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-16 CA CA002057734A patent/CA2057734C/fr not_active Expired - Fee Related
- 1991-12-23 AT AT91122167T patent/ATE150764T1/de not_active IP Right Cessation
- 1991-12-23 EP EP91122167A patent/EP0497001B1/fr not_active Expired - Lifetime
- 1991-12-23 DE DE69125360T patent/DE69125360T2/de not_active Expired - Fee Related
- 1991-12-23 ES ES91122167T patent/ES2099125T3/es not_active Expired - Lifetime
- 1991-12-27 US US07/813,722 patent/US5223488A/en not_active Expired - Fee Related
- 1991-12-27 RU SU915010693A patent/RU2043994C1/ru active
- 1991-12-27 KR KR1019910024588A patent/KR0178794B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0178794B1 (ko) | 1999-04-01 |
| JP2921124B2 (ja) | 1999-07-19 |
| ATE150764T1 (de) | 1997-04-15 |
| DE69125360T2 (de) | 1997-10-23 |
| EP0497001A2 (fr) | 1992-08-05 |
| CA2057734C (fr) | 1997-12-02 |
| JPH04230698A (ja) | 1992-08-19 |
| KR920012110A (ko) | 1992-07-25 |
| ES2099125T3 (es) | 1997-05-16 |
| EP0497001A3 (en) | 1993-06-23 |
| RU2043994C1 (ru) | 1995-09-20 |
| DE69125360D1 (de) | 1997-04-30 |
| EP0497001B1 (fr) | 1997-03-26 |
| US5223488A (en) | 1993-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |