ES2099125T3 - Ester alquilico de glutation de tipo oxidado. - Google Patents

Ester alquilico de glutation de tipo oxidado.

Info

Publication number
ES2099125T3
ES2099125T3 ES91122167T ES91122167T ES2099125T3 ES 2099125 T3 ES2099125 T3 ES 2099125T3 ES 91122167 T ES91122167 T ES 91122167T ES 91122167 T ES91122167 T ES 91122167T ES 2099125 T3 ES2099125 T3 ES 2099125T3
Authority
ES
Spain
Prior art keywords
ester
alkyl
glutation
chem
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91122167T
Other languages
English (en)
Inventor
Ogata Kazumi
Sakagami Takahiro
Isowaki Yuichi
Tsuruoka Hideki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2099125T3 publication Critical patent/ES2099125T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN ESTER ALQUILO DE GLUTADIONA DE TIPO OXIDATIVO REPRESENTADO POR LA FORMULA GENERAL (I), DONDE R DESIGNA UN GRUPO ALQUILO INFERIOR, Y UNA DE SUS SALES; UN METODO PARA PREPARAR DICHO ESTER QUE ESTA COMPUESTO POR UN ESTER MONOALQUILO DE GLUTADIONA DE TIPO REDUCIDO REPRESENTADO POR LA FORMULA (II), DONDE R ES COMO SE DEFINE ARRIBA, CON EL AIRE, PEROXIDO DE HIDROGENO O YODO EN UNA SOLUCION ACUOSA; Y UNA COMPOSICION FARMACEUTICA Y UN METODO PARA LA SUPRESION DE LAS ENFERMEDADES HEPATICAS CARACTERIZADO EN QUE CONTIENE COMO CONSTITUYENTE ACTIVO DICHO ESTER O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES.
ES91122167T 1990-12-28 1991-12-23 Ester alquilico de glutation de tipo oxidado. Expired - Lifetime ES2099125T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2416855A JP2921124B2 (ja) 1990-12-28 1990-12-28 酸化型グルタチオンアルキルエステル

Publications (1)

Publication Number Publication Date
ES2099125T3 true ES2099125T3 (es) 1997-05-16

Family

ID=18525041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91122167T Expired - Lifetime ES2099125T3 (es) 1990-12-28 1991-12-23 Ester alquilico de glutation de tipo oxidado.

Country Status (9)

Country Link
US (1) US5223488A (es)
EP (1) EP0497001B1 (es)
JP (1) JP2921124B2 (es)
KR (1) KR0178794B1 (es)
AT (1) ATE150764T1 (es)
CA (1) CA2057734C (es)
DE (1) DE69125360T2 (es)
ES (1) ES2099125T3 (es)
RU (1) RU2043994C1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09124509A (ja) * 1995-10-27 1997-05-13 Sumitomo Electric Ind Ltd 肝炎治療剤
EP0869809B1 (en) * 1995-12-14 2002-03-27 Novelos Therapeutics, Inc. Oxidized glutathione as cytokine and hemopoietic factor endogenous production enhancer
US6251857B1 (en) * 1995-12-14 2001-06-26 Novelos Therapeutics, Inc. Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
JP2002503700A (ja) 1998-02-24 2002-02-05 ドヴェテイル テクノロジー インコーポレイテッド 新規なジスルフィドおよびチオール化合物
US20070142267A1 (en) 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
RU2144374C1 (ru) * 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток
US7172905B2 (en) * 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
EP2500729A1 (en) * 2002-07-05 2012-09-19 The University of Chicago Characterization of biochips containing self-assembled monolayers
US7080671B2 (en) * 2002-12-17 2006-07-25 Paraphase, Inc. Replacement vehicle fuel intake device
US6941707B2 (en) * 2003-05-02 2005-09-13 Certainteed Corporation Vented soffit panel
US20110064828A1 (en) * 2009-09-11 2011-03-17 Novelos Therapeutics, Incorporated Treatment of metastatic tumors and other conditions
US20130245198A1 (en) 2012-03-14 2013-09-19 Ralf Mruk Pneumatic tire
US20130245199A1 (en) 2012-03-14 2013-09-19 Ralf Mruk Functionalized elastomer
RU2692065C1 (ru) * 2018-04-05 2019-06-20 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Глутатионаммониевые соли o,o-диорганилдитиофосфорных кислот, обладающие антиоксидантной и противоопухолевой активностью

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879370A (en) * 1983-12-02 1989-11-07 Cornell Research Foundation, Inc. Glutathione delivery system
FR2579461B1 (fr) * 1985-03-28 1988-08-26 Strasbourg Universite L Pasteu Amides de l'acide para-methoxycinnamique et de l'acide urocanique utilises comme filtres solaires; procedes d'obtention, compositions dermo-pharmaceutiques et cosmetiques les contenant et applications
JPH075631B2 (ja) * 1986-03-19 1995-01-25 参天製薬株式会社 グルタチオン誘導体

Also Published As

Publication number Publication date
KR920012110A (ko) 1992-07-25
EP0497001A2 (en) 1992-08-05
JPH04230698A (ja) 1992-08-19
EP0497001A3 (en) 1993-06-23
JP2921124B2 (ja) 1999-07-19
US5223488A (en) 1993-06-29
CA2057734A1 (en) 1992-06-29
DE69125360T2 (de) 1997-10-23
CA2057734C (en) 1997-12-02
KR0178794B1 (ko) 1999-04-01
RU2043994C1 (ru) 1995-09-20
DE69125360D1 (de) 1997-04-30
EP0497001B1 (en) 1997-03-26
ATE150764T1 (de) 1997-04-15

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