ES2099125T3 - Ester alquilico de glutation de tipo oxidado. - Google Patents
Ester alquilico de glutation de tipo oxidado.Info
- Publication number
- ES2099125T3 ES2099125T3 ES91122167T ES91122167T ES2099125T3 ES 2099125 T3 ES2099125 T3 ES 2099125T3 ES 91122167 T ES91122167 T ES 91122167T ES 91122167 T ES91122167 T ES 91122167T ES 2099125 T3 ES2099125 T3 ES 2099125T3
- Authority
- ES
- Spain
- Prior art keywords
- ester
- alkyl
- glutation
- chem
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE DESCRIBE UN ESTER ALQUILO DE GLUTADIONA DE TIPO OXIDATIVO REPRESENTADO POR LA FORMULA GENERAL (I), DONDE R DESIGNA UN GRUPO ALQUILO INFERIOR, Y UNA DE SUS SALES; UN METODO PARA PREPARAR DICHO ESTER QUE ESTA COMPUESTO POR UN ESTER MONOALQUILO DE GLUTADIONA DE TIPO REDUCIDO REPRESENTADO POR LA FORMULA (II), DONDE R ES COMO SE DEFINE ARRIBA, CON EL AIRE, PEROXIDO DE HIDROGENO O YODO EN UNA SOLUCION ACUOSA; Y UNA COMPOSICION FARMACEUTICA Y UN METODO PARA LA SUPRESION DE LAS ENFERMEDADES HEPATICAS CARACTERIZADO EN QUE CONTIENE COMO CONSTITUYENTE ACTIVO DICHO ESTER O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2416855A JP2921124B2 (ja) | 1990-12-28 | 1990-12-28 | 酸化型グルタチオンアルキルエステル |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2099125T3 true ES2099125T3 (es) | 1997-05-16 |
Family
ID=18525041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91122167T Expired - Lifetime ES2099125T3 (es) | 1990-12-28 | 1991-12-23 | Ester alquilico de glutation de tipo oxidado. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5223488A (es) |
EP (1) | EP0497001B1 (es) |
JP (1) | JP2921124B2 (es) |
KR (1) | KR0178794B1 (es) |
AT (1) | ATE150764T1 (es) |
CA (1) | CA2057734C (es) |
DE (1) | DE69125360T2 (es) |
ES (1) | ES2099125T3 (es) |
RU (1) | RU2043994C1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09124509A (ja) * | 1995-10-27 | 1997-05-13 | Sumitomo Electric Ind Ltd | 肝炎治療剤 |
EP0869809B1 (en) * | 1995-12-14 | 2002-03-27 | Novelos Therapeutics, Inc. | Oxidized glutathione as cytokine and hemopoietic factor endogenous production enhancer |
US6251857B1 (en) * | 1995-12-14 | 2001-06-26 | Novelos Therapeutics, Inc. | Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof |
JP2002503700A (ja) | 1998-02-24 | 2002-02-05 | ドヴェテイル テクノロジー インコーポレイテッド | 新規なジスルフィドおよびチオール化合物 |
US20070142267A1 (en) | 1998-11-23 | 2007-06-21 | Novelos Therapeutics, Inc. | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells |
RU2144374C1 (ru) * | 1998-11-23 | 2000-01-20 | Закрытое акционерное общество "ВАМ" | Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток |
US7172905B2 (en) * | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
EP2500729A1 (en) * | 2002-07-05 | 2012-09-19 | The University of Chicago | Characterization of biochips containing self-assembled monolayers |
US7080671B2 (en) * | 2002-12-17 | 2006-07-25 | Paraphase, Inc. | Replacement vehicle fuel intake device |
US6941707B2 (en) * | 2003-05-02 | 2005-09-13 | Certainteed Corporation | Vented soffit panel |
US20110064828A1 (en) * | 2009-09-11 | 2011-03-17 | Novelos Therapeutics, Incorporated | Treatment of metastatic tumors and other conditions |
US20130245198A1 (en) | 2012-03-14 | 2013-09-19 | Ralf Mruk | Pneumatic tire |
US20130245199A1 (en) | 2012-03-14 | 2013-09-19 | Ralf Mruk | Functionalized elastomer |
RU2692065C1 (ru) * | 2018-04-05 | 2019-06-20 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Глутатионаммониевые соли o,o-диорганилдитиофосфорных кислот, обладающие антиоксидантной и противоопухолевой активностью |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879370A (en) * | 1983-12-02 | 1989-11-07 | Cornell Research Foundation, Inc. | Glutathione delivery system |
FR2579461B1 (fr) * | 1985-03-28 | 1988-08-26 | Strasbourg Universite L Pasteu | Amides de l'acide para-methoxycinnamique et de l'acide urocanique utilises comme filtres solaires; procedes d'obtention, compositions dermo-pharmaceutiques et cosmetiques les contenant et applications |
JPH075631B2 (ja) * | 1986-03-19 | 1995-01-25 | 参天製薬株式会社 | グルタチオン誘導体 |
-
1990
- 1990-12-28 JP JP2416855A patent/JP2921124B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-16 CA CA002057734A patent/CA2057734C/en not_active Expired - Fee Related
- 1991-12-23 AT AT91122167T patent/ATE150764T1/de not_active IP Right Cessation
- 1991-12-23 ES ES91122167T patent/ES2099125T3/es not_active Expired - Lifetime
- 1991-12-23 EP EP91122167A patent/EP0497001B1/en not_active Expired - Lifetime
- 1991-12-23 DE DE69125360T patent/DE69125360T2/de not_active Expired - Fee Related
- 1991-12-27 KR KR1019910024588A patent/KR0178794B1/ko not_active IP Right Cessation
- 1991-12-27 US US07/813,722 patent/US5223488A/en not_active Expired - Fee Related
- 1991-12-27 RU SU915010693A patent/RU2043994C1/ru active
Also Published As
Publication number | Publication date |
---|---|
KR920012110A (ko) | 1992-07-25 |
EP0497001A2 (en) | 1992-08-05 |
JPH04230698A (ja) | 1992-08-19 |
EP0497001A3 (en) | 1993-06-23 |
JP2921124B2 (ja) | 1999-07-19 |
US5223488A (en) | 1993-06-29 |
CA2057734A1 (en) | 1992-06-29 |
DE69125360T2 (de) | 1997-10-23 |
CA2057734C (en) | 1997-12-02 |
KR0178794B1 (ko) | 1999-04-01 |
RU2043994C1 (ru) | 1995-09-20 |
DE69125360D1 (de) | 1997-04-30 |
EP0497001B1 (en) | 1997-03-26 |
ATE150764T1 (de) | 1997-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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