CA2045578A1 - Ligands recepteurs de l'anaphylatoxine - Google Patents

Ligands recepteurs de l'anaphylatoxine

Info

Publication number
CA2045578A1
CA2045578A1 CA002045578A CA2045578A CA2045578A1 CA 2045578 A1 CA2045578 A1 CA 2045578A1 CA 002045578 A CA002045578 A CA 002045578A CA 2045578 A CA2045578 A CA 2045578A CA 2045578 A1 CA2045578 A1 CA 2045578A1
Authority
CA
Canada
Prior art keywords
alkyl
amino
group
lysyl
cyclohexylpropanoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002045578A
Other languages
English (en)
Inventor
Megumi Kawai
Yat S. Or
Paul E. Wiedeman
Jay R. Luly
Mikel P. Moyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Megumi Kawai
Yat S. Or
Paul E. Wiedeman
Jay R. Luly
Mikel P. Moyer
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megumi Kawai, Yat S. Or, Paul E. Wiedeman, Jay R. Luly, Mikel P. Moyer, Abbott Laboratories filed Critical Megumi Kawai
Publication of CA2045578A1 publication Critical patent/CA2045578A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
CA002045578A 1989-01-31 1990-01-16 Ligands recepteurs de l'anaphylatoxine Abandoned CA2045578A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30469389A 1989-01-31 1989-01-31
US304,693 1989-01-31

Publications (1)

Publication Number Publication Date
CA2045578A1 true CA2045578A1 (fr) 1990-08-01

Family

ID=23177579

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002045578A Abandoned CA2045578A1 (fr) 1989-01-31 1990-01-16 Ligands recepteurs de l'anaphylatoxine

Country Status (5)

Country Link
EP (1) EP0456758A4 (fr)
JP (1) JPH04503073A (fr)
CA (1) CA2045578A1 (fr)
GR (1) GR900100052A (fr)
WO (1) WO1990009162A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599523A (zh) * 2013-11-25 2014-02-26 中国人民解放军第二军医大学 五肽代谢物在制备抗炎药物中的应用

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387671A (en) * 1990-12-27 1995-02-07 Abbott Laboratories Hexa- and heptapeptide anaphylatoxin-receptor ligands
US5386011A (en) * 1990-12-27 1995-01-31 Abbott Laboratories Hexapeptide anaphylatoxin-receptor ligands
US5190922A (en) * 1991-06-04 1993-03-02 Abbott Laboratories Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands
WO1994007518A1 (fr) * 1992-09-25 1994-04-14 Abbott Laboratories Ligands de recepteurs d'anaphylatoxine contenant des restes lipophiles
US5807824A (en) * 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
US5837499A (en) * 1993-12-06 1998-11-17 Ciba-Geigy Corporation DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
US5614370A (en) * 1994-03-18 1997-03-25 Merck & Co., Inc. Assay to identify human C5a antagonists and agonists
ES2168456T3 (es) * 1995-01-16 2002-06-16 North Sydney Area Health Serv Peptidos que afectan a los linfocitos t.
SE9603468D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603461D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
SE9603462D0 (sv) * 1996-09-23 1996-09-23 Astra Ab New compounds
US6998106B1 (en) * 1998-12-01 2006-02-14 Duke University Radioconjugation of internalizing antibodies
TW200502221A (en) 2002-10-03 2005-01-16 Astrazeneca Ab Novel lactams and uses thereof
JP2006520396A (ja) * 2003-03-14 2006-09-07 アストラゼネカ・アクチエボラーグ 新規なラクタム及びその使用
EP1498422A1 (fr) * 2003-07-17 2005-01-19 Jerini AG Antagonistes du Recepteur C5a
NZ546504A (en) * 2003-10-24 2009-01-31 Aventis Pharma Inc Novel keto-oxadiazole derivatives as cathepsin inhibitors
KR20070104355A (ko) * 2005-01-17 2007-10-25 제리니 아게 Ｃ5ａ 수용체 안타고니스트
EP1739078A1 (fr) 2005-05-30 2007-01-03 Jerini AG Antagonistes du recepteur C5a
EP2468295A1 (fr) * 2010-12-21 2012-06-27 Affiris AG Vaccins à base de peptides de la proteine C5a du complement
EP2666785A1 (fr) 2012-05-23 2013-11-27 Affiris AG Vaccins basés sur la protéine complément C5a
US11918624B2 (en) 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692511A (en) * 1984-07-03 1987-09-08 Immunetech Pharmaceuticals Peptide antagonists for the C5a anaphylatoxin
CA1290097C (fr) * 1985-07-24 1991-10-01 Merck & Co., Inc. Inhibiteurs d'enzymes de type peptide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599523A (zh) * 2013-11-25 2014-02-26 中国人民解放军第二军医大学 五肽代谢物在制备抗炎药物中的应用
CN103599523B (zh) * 2013-11-25 2016-08-17 中国人民解放军第二军医大学 五肽代谢物在制备抗炎药物中的应用

Also Published As

Publication number Publication date
WO1990009162A2 (fr) 1990-08-23
JPH04503073A (ja) 1992-06-04
EP0456758A1 (fr) 1991-11-21
EP0456758A4 (en) 1992-07-08
GR900100052A (el) 1991-06-07
WO1990009162A3 (fr) 1990-11-29

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Legal Events

Date Code Title Description
FZDE Dead