CA2042905A1 - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- CA2042905A1 CA2042905A1 CA002042905A CA2042905A CA2042905A1 CA 2042905 A1 CA2042905 A1 CA 2042905A1 CA 002042905 A CA002042905 A CA 002042905A CA 2042905 A CA2042905 A CA 2042905A CA 2042905 A1 CA2042905 A1 CA 2042905A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- salt
- formula
- alkyl
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9011335.8 | 1990-05-21 | ||
| GB909011335A GB9011335D0 (en) | 1990-05-21 | 1990-05-21 | Indolebutyric acid derivatives and process for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2042905A1 true CA2042905A1 (en) | 1991-11-22 |
Family
ID=10676312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002042905A Abandoned CA2042905A1 (en) | 1990-05-21 | 1991-05-17 | Indole derivatives |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0458207B1 (enExample) |
| JP (1) | JPH0678307B2 (enExample) |
| KR (1) | KR910019975A (enExample) |
| CN (1) | CN1030701C (enExample) |
| AT (1) | ATE150747T1 (enExample) |
| AU (1) | AU645560B2 (enExample) |
| CA (1) | CA2042905A1 (enExample) |
| DE (1) | DE69125308T2 (enExample) |
| DK (1) | DK0458207T3 (enExample) |
| FI (1) | FI912375A7 (enExample) |
| GB (1) | GB9011335D0 (enExample) |
| GR (1) | GR3022953T3 (enExample) |
| HU (2) | HUT60471A (enExample) |
| IE (1) | IE911641A1 (enExample) |
| NO (1) | NO175475C (enExample) |
| PT (1) | PT97717B (enExample) |
| RU (1) | RU2045518C1 (enExample) |
| ZA (1) | ZA913457B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2120942C1 (ru) * | 1991-06-17 | 1998-10-27 | Фудзисава Фармасьютикал Ко., Лтд. | ПРОИЗВОДНЫЕ ИНДОЛИЗИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ |
| US5334716A (en) * | 1991-06-17 | 1994-08-02 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic derivatives |
| GB9115951D0 (en) * | 1991-07-24 | 1991-09-11 | Pfizer Ltd | Indoles |
| CA2118697A1 (en) * | 1991-09-11 | 1993-03-18 | Satoshi Okada | Indole derivatives as 5-alpha-reductase inhibitor |
| GB9127531D0 (en) * | 1991-12-31 | 1992-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compound |
| GB9204024D0 (en) * | 1992-02-25 | 1992-04-08 | Fujisawa Pharmaceutical Co | Indole derivatives |
| GB9204365D0 (en) * | 1992-02-28 | 1992-04-08 | Pfizer Ltd | Indoles |
| KR950701527A (ko) * | 1992-05-21 | 1995-04-28 | 라브리 페르낭 | 테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY) |
| GB9302577D0 (en) * | 1993-02-10 | 1993-03-24 | Fujisawa Pharmaceutical Co | Indole derivatives |
| US5530019A (en) * | 1993-04-05 | 1996-06-25 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives useful as testosterone 5α-reductase inhibitors |
| GB9310092D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | Indole derivatives |
| IL109728A0 (en) * | 1993-05-28 | 1994-08-26 | Pfizer Res & Dev | Indoles |
| GB9317096D0 (en) * | 1993-08-17 | 1993-09-29 | Pfizer Ltd | Indoles |
| US5760040A (en) * | 1994-03-30 | 1998-06-02 | Zeria Pharmaceutical Co., Ltd. | Indole derivative for treating overproduction of dihydrotestosterone |
| GB9409583D0 (en) * | 1994-05-13 | 1994-07-06 | Pfizer Ltd | Indoles |
| AP2000001929A0 (en) * | 1998-03-31 | 2000-09-30 | Inst For Pharm Discovery Inc | Substituted indolealkanoic acids. |
| WO2003020311A1 (fr) * | 2001-08-28 | 2003-03-13 | Fujisawa Pharmaceutical Co., Ltd. | Remedes contre les maladies de la peau |
| ATE406363T1 (de) | 2003-05-09 | 2008-09-15 | Hoffmann La Roche | Methylindole und methylpyrrolopyridine als alpha- 1-adrenerge agonisten |
| TW201329025A (zh) * | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| EP3774767B1 (en) * | 2018-04-05 | 2025-10-29 | Beth Israel Deaconess Medical Center, Inc. | Aryl hydrocarbon receptor modulators and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7337M (enExample) * | 1968-01-11 | 1969-10-13 | ||
| PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
-
1990
- 1990-05-21 GB GB909011335A patent/GB9011335D0/en active Pending
-
1991
- 1991-05-07 ZA ZA913457A patent/ZA913457B/xx unknown
- 1991-05-13 IE IE164191A patent/IE911641A1/en unknown
- 1991-05-16 FI FI912375A patent/FI912375A7/fi not_active Application Discontinuation
- 1991-05-16 AU AU77116/91A patent/AU645560B2/en not_active Ceased
- 1991-05-16 NO NO911938A patent/NO175475C/no unknown
- 1991-05-17 DE DE69125308T patent/DE69125308T2/de not_active Expired - Fee Related
- 1991-05-17 CA CA002042905A patent/CA2042905A1/en not_active Abandoned
- 1991-05-17 EP EP91108019A patent/EP0458207B1/en not_active Expired - Lifetime
- 1991-05-17 AT AT91108019T patent/ATE150747T1/de not_active IP Right Cessation
- 1991-05-17 DK DK91108019.0T patent/DK0458207T3/da active
- 1991-05-20 KR KR1019910008139A patent/KR910019975A/ko not_active Ceased
- 1991-05-20 CN CN91103461A patent/CN1030701C/zh not_active Expired - Fee Related
- 1991-05-20 PT PT97717A patent/PT97717B/pt not_active IP Right Cessation
- 1991-05-20 HU HU911681A patent/HUT60471A/hu unknown
- 1991-05-20 RU SU914895529A patent/RU2045518C1/ru active
- 1991-05-21 JP JP3229864A patent/JPH0678307B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-22 HU HU95P/P00391P patent/HU211637A9/hu unknown
-
1997
- 1997-03-27 GR GR970400551T patent/GR3022953T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO911938L (no) | 1991-11-22 |
| DE69125308T2 (de) | 1997-07-10 |
| NO175475B (no) | 1994-07-11 |
| HU211637A9 (en) | 1995-12-28 |
| JPH04244061A (ja) | 1992-09-01 |
| PT97717B (pt) | 1998-08-31 |
| CN1030701C (zh) | 1996-01-17 |
| DK0458207T3 (enExample) | 1997-04-21 |
| NO911938D0 (no) | 1991-05-16 |
| RU2045518C1 (ru) | 1995-10-10 |
| AU7711691A (en) | 1991-11-21 |
| DE69125308D1 (de) | 1997-04-30 |
| PT97717A (pt) | 1992-02-28 |
| GR3022953T3 (en) | 1997-06-30 |
| EP0458207A2 (en) | 1991-11-27 |
| AU645560B2 (en) | 1994-01-20 |
| FI912375A7 (fi) | 1991-11-22 |
| CN1056685A (zh) | 1991-12-04 |
| IE911641A1 (en) | 1991-12-04 |
| ATE150747T1 (de) | 1997-04-15 |
| KR910019975A (ko) | 1991-12-19 |
| EP0458207B1 (en) | 1997-03-26 |
| HU911681D0 (en) | 1991-11-28 |
| NO175475C (no) | 1994-10-19 |
| JPH0678307B2 (ja) | 1994-10-05 |
| HUT60471A (en) | 1992-09-28 |
| GB9011335D0 (en) | 1990-07-11 |
| FI912375A0 (fi) | 1991-05-16 |
| ZA913457B (en) | 1992-02-26 |
| EP0458207A3 (en) | 1992-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |