CA2021299A1 - Oxydation enzymatique de la cephalosporine c en acide glutaryl-7-aminocephalosporique - Google Patents

Oxydation enzymatique de la cephalosporine c en acide glutaryl-7-aminocephalosporique

Info

Publication number
CA2021299A1
CA2021299A1 CA2021299A CA2021299A CA2021299A1 CA 2021299 A1 CA2021299 A1 CA 2021299A1 CA 2021299 A CA2021299 A CA 2021299A CA 2021299 A CA2021299 A CA 2021299A CA 2021299 A1 CA2021299 A1 CA 2021299A1
Authority
CA
Canada
Prior art keywords
glutaryl
ceph
cephalosporanic acid
enzymatic oxidation
amino cephalosporanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2021299A
Other languages
English (en)
Other versions
CA2021299C (fr
Inventor
Jeffrey T. Vicenzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to CA002268710A priority Critical patent/CA2268710C/fr
Publication of CA2021299A1 publication Critical patent/CA2021299A1/fr
Application granted granted Critical
Publication of CA2021299C publication Critical patent/CA2021299C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA002021299A 1989-07-19 1990-07-16 Oxydation enzymatique de la cephalosporine c en acide glutaryl-7-aminocephalosporique Expired - Fee Related CA2021299C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002268710A CA2268710C (fr) 1989-07-19 1990-07-16 Oxidation enzymatique ameliore de ceph c en acide glutaryl-7-amino cephalosporanique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38250589A 1989-07-19 1989-07-19
US07/382,505 1989-07-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002268710A Division CA2268710C (fr) 1989-07-19 1990-07-16 Oxidation enzymatique ameliore de ceph c en acide glutaryl-7-amino cephalosporanique

Publications (2)

Publication Number Publication Date
CA2021299A1 true CA2021299A1 (fr) 1991-01-20
CA2021299C CA2021299C (fr) 1999-08-17

Family

ID=23509253

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002021299A Expired - Fee Related CA2021299C (fr) 1989-07-19 1990-07-16 Oxydation enzymatique de la cephalosporine c en acide glutaryl-7-aminocephalosporique
CA002268710A Expired - Fee Related CA2268710C (fr) 1989-07-19 1990-07-16 Oxidation enzymatique ameliore de ceph c en acide glutaryl-7-amino cephalosporanique

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002268710A Expired - Fee Related CA2268710C (fr) 1989-07-19 1990-07-16 Oxidation enzymatique ameliore de ceph c en acide glutaryl-7-amino cephalosporanique

Country Status (13)

Country Link
US (2) US5424203A (fr)
EP (2) EP0601996A1 (fr)
JP (1) JP2883173B2 (fr)
KR (1) KR0163175B1 (fr)
AT (1) ATE129012T1 (fr)
CA (2) CA2021299C (fr)
DE (1) DE69022909T2 (fr)
DK (1) DK0409521T3 (fr)
ES (1) ES2079442T3 (fr)
GR (1) GR3017731T3 (fr)
HU (1) HU212587B (fr)
IE (1) IE71523B1 (fr)
IL (1) IL95090A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69022909T2 (de) * 1989-07-19 1996-04-11 Lilly Co Eli Enzymatische Oxidation von Ceph C zu Glutaryl-7-Aminocephalosporansäure.
DE4028119C1 (fr) * 1990-09-05 1991-12-05 Hoechst Ag, 6230 Frankfurt, De
CA2100987C (fr) * 1992-07-27 1999-06-15 Kaoru Furuya Un transformant pouvant produire une d-amino-acide oxydase
EP0600247A3 (fr) * 1992-11-05 1995-05-10 Hoechst Ag Méthode de désactivation sélective de protéine non désirable dans un mélange, protéinique, par les radiations d'un four à microondes.
ES2097080B1 (es) * 1993-03-08 1997-11-16 Asahi Chemical Ind Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
EP0865485A1 (fr) * 1995-12-07 1998-09-23 Novo Nordisk A/S Inactivation selective d'activites enzymatiques
EP0991752A2 (fr) 1997-09-09 2000-04-12 Biochemie Gesellschaft M.B.H. Enzymes exemptes d'esterase
AU2002227889A1 (en) * 2001-01-31 2002-08-12 Novozymes A/S Oxidase free of catalase side activities
KR100512774B1 (ko) * 2001-10-06 2005-09-07 종근당바이오 주식회사 7-아미노세팔로스포란산의 제조를 위한 세팔로스포린ｃ배양액의 전처리방법
US20090208543A1 (en) * 2008-01-22 2009-08-20 Oral Health Clinical Services Method and apparatus for applying a protective oral care composition
US10702503B2 (en) 2016-06-21 2020-07-07 Phc Holdings Corporation Catalase inhibitor and method for measuring analyte using catalase inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
GB1474519A (fr) * 1973-05-14 1977-05-25
US3976546A (en) * 1974-11-08 1976-08-24 Glaxo Laboratories Limited Cephalosporins
GB1494452A (en) * 1975-01-22 1977-12-07 Asahi Chemical Ind Process for preparing 7-aminocephalosporanic acid derivatives
US4394450A (en) * 1982-03-01 1983-07-19 Miles Laboratories, Inc. Method for purification of uricase
DE3447023A1 (de) * 1984-12-22 1986-06-26 Hoechst Ag, 6230 Frankfurt Neue d-aminosaeure-transaminase und ihre verwendung
DE69022909T2 (de) * 1989-07-19 1996-04-11 Lilly Co Eli Enzymatische Oxidation von Ceph C zu Glutaryl-7-Aminocephalosporansäure.

Also Published As

Publication number Publication date
HUT59727A (en) 1992-06-29
US5424203A (en) 1995-06-13
DE69022909T2 (de) 1996-04-11
KR910003114A (ko) 1991-02-26
EP0409521B1 (fr) 1995-10-11
DE69022909D1 (de) 1995-11-16
EP0601996A1 (fr) 1994-06-15
KR0163175B1 (ko) 1998-11-16
IL95090A0 (en) 1991-06-10
HU212587B (en) 1996-08-29
CA2268710C (fr) 2000-09-26
IE71523B1 (en) 1997-02-12
JP2883173B2 (ja) 1999-04-19
IL95090A (en) 1995-08-31
GR3017731T3 (en) 1996-01-31
IE902623A1 (en) 1991-02-27
HU904539D0 (en) 1990-12-28
CA2021299C (fr) 1999-08-17
JPH0353879A (ja) 1991-03-07
EP0409521A3 (en) 1991-09-11
EP0409521A2 (fr) 1991-01-23
ES2079442T3 (es) 1996-01-16
US5559006A (en) 1996-09-24
DK0409521T3 (da) 1996-02-05
ATE129012T1 (de) 1995-10-15

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