CA2018308A1 - Pyrazines anticonvulsivantes - Google Patents

Pyrazines anticonvulsivantes

Info

Publication number
CA2018308A1
CA2018308A1 CA2018308A CA2018308A CA2018308A1 CA 2018308 A1 CA2018308 A1 CA 2018308A1 CA 2018308 A CA2018308 A CA 2018308A CA 2018308 A CA2018308 A CA 2018308A CA 2018308 A1 CA2018308 A1 CA 2018308A1
Authority
CA
Canada
Prior art keywords
pyrazines
anticonvulsant
triazolo
epilepsy
class
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2018308A
Other languages
English (en)
Other versions
CA2018308C (fr
Inventor
James L. Kelley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of CA2018308A1 publication Critical patent/CA2018308A1/fr
Application granted granted Critical
Publication of CA2018308C publication Critical patent/CA2018308C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002018308A 1989-06-06 1990-06-05 Pyrazines anticonvulsivantes Expired - Lifetime CA2018308C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898913011A GB8913011D0 (en) 1989-06-06 1989-06-06 Anticonvulsant pyrazines
GB8913011.6 1989-06-06

Publications (2)

Publication Number Publication Date
CA2018308A1 true CA2018308A1 (fr) 1990-12-06
CA2018308C CA2018308C (fr) 2000-08-01

Family

ID=10657983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002018308A Expired - Lifetime CA2018308C (fr) 1989-06-06 1990-06-05 Pyrazines anticonvulsivantes

Country Status (11)

Country Link
US (1) US5095018A (fr)
EP (1) EP0402096B1 (fr)
JP (1) JP3027762B2 (fr)
AT (1) ATE141604T1 (fr)
AU (1) AU628581B2 (fr)
CA (1) CA2018308C (fr)
DD (1) DD294944A5 (fr)
DE (1) DE69028147T2 (fr)
ES (1) ES2091796T3 (fr)
GB (1) GB8913011D0 (fr)
NZ (1) NZ233928A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018981A1 (fr) * 1993-02-22 1994-09-01 Merck & Co., Inc. Antagonistes des recepteurs de fibrinogene
US5821241A (en) * 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
CN1285834A (zh) 1997-11-11 2001-02-28 小野药品工业株式会社 稠合吡嗪化合物
US8329705B2 (en) * 2009-12-30 2012-12-11 Arqule, Inc. Substituted triazolo-pyrazine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1146770A (en) * 1967-02-03 1969-03-26 Ici Ltd S-triazolo[4,3-a]pyrazine derivatives
JPS5129766B2 (fr) * 1971-10-04 1976-08-27
US4056632A (en) * 1975-07-21 1977-11-01 Burroughs Wellcome Co. 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4438266A (en) * 1982-05-17 1984-03-20 Merck & Co., Inc. Triazolopyrazinamines useful as adjuncts to radiation therapy
GB8408615D0 (en) * 1984-04-04 1984-05-16 Wellcome Found Heterocyclic compounds
MC1673A1 (fr) * 1984-06-27 1986-06-03 Wellcome Found Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments

Also Published As

Publication number Publication date
ATE141604T1 (de) 1996-09-15
NZ233928A (en) 1992-10-28
JP3027762B2 (ja) 2000-04-04
EP0402096B1 (fr) 1996-08-21
AU628581B2 (en) 1992-09-17
DE69028147T2 (de) 1997-01-02
EP0402096A2 (fr) 1990-12-12
ES2091796T3 (es) 1996-11-16
GB8913011D0 (en) 1989-07-26
CA2018308C (fr) 2000-08-01
US5095018A (en) 1992-03-10
DE69028147D1 (de) 1996-09-26
AU5684290A (en) 1990-12-13
DD294944A5 (de) 1991-10-17
EP0402096A3 (fr) 1991-09-18
JPH0320276A (ja) 1991-01-29

Similar Documents

Publication Publication Date Title
CA2118757A1 (fr) Composes a base d'azacyclohexapeptide
HUT61311A (en) Process for producing /1,2,4/triazolo/1,5-a//1,3,5/-traizine and pyrazolo/2,3-a//1,3,5/-triazine derivatives and pharmaceutical compositions comprising same as active ingredient
IL108372A0 (en) 2,6-Diaminopurine derivatives, their preparation and pharmaceutical compositions containing them
CA2150251A1 (fr) Lyospheres contenant de la gonadotropine
CA2152615A1 (fr) Compositions pharmaceutiques a base d'atovaquone
JPS6468372A (en) 3,7-diazabicyclo(3,3,1)nonane compound, manufacture, medicine having cardiac effect properties and intermediate product
IL111011A0 (en) Bisbenzimidazole compounds, their preparation and pharmaceutical compositions containing them
CA2100126A1 (fr) Complexes d'inclusion d'acide 5,10-methylenetetrahydrofolique-cyclodextrine
IL106761A0 (en) 4,5-dihydro-4-oxo-pyrrolo(1,2-a)quinoxalinones and corresponding aza analogs,their preparation and pharmaceutical compositions containing them
IL85290A0 (en) Substituted 3,4-dihydro-2h-benzopyrans,processes for their preparation and pharmaceutical compositions containing same
HUT47276A (en) Process for producing pyrazolo/1,5-a/pyrimidine derivatives and pharmaceutical compositions containing them
IL108624A0 (en) Pseudopeptides, their preparation and pharmaceutical compositions containing them
HUT67299A (en) Novel benzodiazepine derivetives, pharmaceutical compositions contaning them and process for their producing
NZ229346A (en) Oxadiazolyl-substituted imidazo(1,5-a)quinoxaline derivatives and pharmaceutical compositions
IL110509A0 (en) Pyrimido pyrimidine compounds, their preparation and pharmaceutical compositions containing them
HUT70407A (en) 9h-imidazo[1,2-a]benzimidazol-3-acetamide derivatives, process for producing them and pharmaceutical compositions containing them
CA2018308A1 (fr) Pyrazines anticonvulsivantes
ZA941088B (en) Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them
ZA892869B (en) 5-fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2-sulfonamides,process for their preparation and composition for their use as herbicides
IL108930A0 (en) 2,3-Diamino-3- hydroxycarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
IL95210A0 (en) 14,17alpha-etheno-and-ethanoestratrienes,process for the preparation thereof and pharmaceutical compositions containing the same
AU3687389A (en) 5-fluoromethyl-1,2,4-triazolo(1,5-a)-pyrimidine-2- sulfonamides, process for their preparation and compositions for their use as herbicides
AU4756693A (en) 1-heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them
AU635828B2 (en) Novel derivatives of 4h-pyrrolo(1,2-a)thieno(2,3-f)(1,4)-diazepine, their process of preparation and the pharmaceutical compositions containing them
IL93662A0 (en) Beta-lactam containing compounds,their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202