ES2091796T3 - Pirazinas anticonvulsionantes. - Google Patents

Pirazinas anticonvulsionantes.

Info

Publication number
ES2091796T3
ES2091796T3 ES90306096T ES90306096T ES2091796T3 ES 2091796 T3 ES2091796 T3 ES 2091796T3 ES 90306096 T ES90306096 T ES 90306096T ES 90306096 T ES90306096 T ES 90306096T ES 2091796 T3 ES2091796 T3 ES 2091796T3
Authority
ES
Spain
Prior art keywords
pirazines
seizure
hydrogen
alkyl
pyrazines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90306096T
Other languages
English (en)
Inventor
James Leroy Kelley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2091796T3 publication Critical patent/ES2091796T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION REVELA UNA NUEVA CLASE DE PIRAZINAS 1,2,4TRIAZOLO[4,3-A], COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN Y METODOS PARA SU PREPARACION. DICHOS COMPUESTOS TIENEN PROPIEDADES ANTICONVULSIVAS Y, POR LO TANTO, RESULTA DE GRAN UTILIDAD EN EL TRATAMIENTO DE LA EPILEPSIA.
ES90306096T 1989-06-06 1990-06-05 Pirazinas anticonvulsionantes. Expired - Lifetime ES2091796T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898913011A GB8913011D0 (en) 1989-06-06 1989-06-06 Anticonvulsant pyrazines

Publications (1)

Publication Number Publication Date
ES2091796T3 true ES2091796T3 (es) 1996-11-16

Family

ID=10657983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90306096T Expired - Lifetime ES2091796T3 (es) 1989-06-06 1990-06-05 Pirazinas anticonvulsionantes.

Country Status (11)

Country Link
US (1) US5095018A (es)
EP (1) EP0402096B1 (es)
JP (1) JP3027762B2 (es)
AT (1) ATE141604T1 (es)
AU (1) AU628581B2 (es)
CA (1) CA2018308C (es)
DD (1) DD294944A5 (es)
DE (1) DE69028147T2 (es)
ES (1) ES2091796T3 (es)
GB (1) GB8913011D0 (es)
NZ (1) NZ233928A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL310386A1 (en) * 1993-02-22 1995-12-11 Merck & Co Inc Antagonists of factor i receptors
US5821241A (en) * 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
KR20010031983A (ko) * 1997-11-11 2001-04-16 우에노 도시오 축합 피라진 화합물
WO2011082267A2 (en) * 2009-12-30 2011-07-07 Arqule, Inc. Substituted triazolo-pyrazine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1146770A (en) * 1967-02-03 1969-03-26 Ici Ltd S-triazolo[4,3-a]pyrazine derivatives
JPS5129766B2 (es) * 1971-10-04 1976-08-27
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4056632A (en) * 1975-07-21 1977-11-01 Burroughs Wellcome Co. 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
US4438266A (en) * 1982-05-17 1984-03-20 Merck & Co., Inc. Triazolopyrazinamines useful as adjuncts to radiation therapy
GB8408615D0 (en) * 1984-04-04 1984-05-16 Wellcome Found Heterocyclic compounds
MC1673A1 (fr) * 1984-06-27 1986-06-03 Wellcome Found Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments

Also Published As

Publication number Publication date
GB8913011D0 (en) 1989-07-26
CA2018308C (en) 2000-08-01
JP3027762B2 (ja) 2000-04-04
ATE141604T1 (de) 1996-09-15
DD294944A5 (de) 1991-10-17
EP0402096B1 (en) 1996-08-21
EP0402096A3 (en) 1991-09-18
EP0402096A2 (en) 1990-12-12
AU5684290A (en) 1990-12-13
US5095018A (en) 1992-03-10
NZ233928A (en) 1992-10-28
DE69028147T2 (de) 1997-01-02
DE69028147D1 (de) 1996-09-26
AU628581B2 (en) 1992-09-17
CA2018308A1 (en) 1990-12-06
JPH0320276A (ja) 1991-01-29

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