CA2016656A1 - Inhibiteurs d'enzyme - Google Patents
Inhibiteurs d'enzymeInfo
- Publication number
- CA2016656A1 CA2016656A1 CA2016656A CA2016656A CA2016656A1 CA 2016656 A1 CA2016656 A1 CA 2016656A1 CA 2016656 A CA2016656 A CA 2016656A CA 2016656 A CA2016656 A CA 2016656A CA 2016656 A1 CA2016656 A1 CA 2016656A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- derivatives
- hydroxy
- peptide
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US362,171 | 1989-06-06 | ||
US07/362,171 US5212157A (en) | 1989-06-06 | 1989-06-06 | Enzyme inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2016656A1 true CA2016656A1 (fr) | 1990-12-06 |
CA2016656C CA2016656C (fr) | 2000-04-11 |
Family
ID=23424961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002016656A Expired - Fee Related CA2016656C (fr) | 1989-06-06 | 1990-05-14 | Inhibiteurs d'enzyme |
Country Status (7)
Country | Link |
---|---|
US (1) | US5212157A (fr) |
EP (1) | EP0401676B1 (fr) |
JP (1) | JPH0347196A (fr) |
AT (1) | ATE116995T1 (fr) |
AU (1) | AU646806B2 (fr) |
CA (1) | CA2016656C (fr) |
DE (1) | DE69015885T2 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516784A (en) * | 1991-08-13 | 1996-05-14 | Schering Corporation | Anti-HIV (AIDS) agents |
EP0633881B1 (fr) * | 1992-03-11 | 2003-10-29 | Narhex Limited | Derives amines d'hydrocarbures a substitution oxo et hydroxy |
US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
US5236934A (en) * | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
US5693815A (en) * | 1993-01-17 | 1997-12-02 | Schering Corporation | Peptides |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
US5849691A (en) * | 1996-02-20 | 1998-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II |
US6291432B1 (en) | 1996-12-27 | 2001-09-18 | Japan Energy Corporation | Tripeptide compounds and anti-AIDS medicine |
US6783947B1 (en) | 1999-09-09 | 2004-08-31 | Dade Behring Marburg Gmbh | Protecting groups for biological labeling |
JP4459629B2 (ja) | 2002-04-12 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | 二環式アミド |
TW201402613A (zh) | 2012-06-19 | 2014-01-16 | 必治妥美雅史谷比公司 | Iap拮抗劑 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1258748A (fr) * | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Peptides inhibiteurs de la renine |
US4680284A (en) * | 1985-01-23 | 1987-07-14 | Abbott Laboratories | Modified phenylalanine peptidylaminodiols |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
JPS63501364A (ja) * | 1985-11-15 | 1988-05-26 | ジ・アップジョン・カンパニ− | S−アリ−ル−d−またはl−またはdl−システイニル、3−(アリ−ルチオ)乳酸または3−(アリ−ルチオ)アルキル基を含有する新規レニン阻害ポリペプチド同族体 |
US4894437A (en) * | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
DE3627877A1 (de) * | 1986-07-30 | 1988-02-04 | Hoechst Ag | Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
HU204285B (en) * | 1986-10-31 | 1991-12-30 | Pfizer | Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them |
BE1002213A5 (fr) * | 1987-04-23 | 1990-10-16 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments. |
US5342922A (en) * | 1989-03-08 | 1994-08-30 | Washington University | Inhibitors of retroviral protease |
-
1989
- 1989-06-06 US US07/362,171 patent/US5212157A/en not_active Expired - Lifetime
-
1990
- 1990-05-14 CA CA002016656A patent/CA2016656C/fr not_active Expired - Fee Related
- 1990-05-31 DE DE69015885T patent/DE69015885T2/de not_active Expired - Fee Related
- 1990-05-31 EP EP90110322A patent/EP0401676B1/fr not_active Expired - Lifetime
- 1990-05-31 AT AT90110322T patent/ATE116995T1/de active
- 1990-06-05 JP JP2147159A patent/JPH0347196A/ja active Pending
- 1990-06-05 AU AU56289/90A patent/AU646806B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU646806B2 (en) | 1994-03-10 |
US5212157A (en) | 1993-05-18 |
EP0401676B1 (fr) | 1995-01-11 |
DE69015885T2 (de) | 1995-06-08 |
ATE116995T1 (de) | 1995-01-15 |
DE69015885D1 (de) | 1995-02-23 |
CA2016656C (fr) | 2000-04-11 |
AU5628990A (en) | 1990-12-13 |
JPH0347196A (ja) | 1991-02-28 |
EP0401676A1 (fr) | 1990-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |