CA2016387A1 - High level expression of functional human plasminogen activator inhibitor (pai-1) in e. coli - Google Patents

High level expression of functional human plasminogen activator inhibitor (pai-1) in e. coli

Info

Publication number
CA2016387A1
CA2016387A1 CA002016387A CA2016387A CA2016387A1 CA 2016387 A1 CA2016387 A1 CA 2016387A1 CA 002016387 A CA002016387 A CA 002016387A CA 2016387 A CA2016387 A CA 2016387A CA 2016387 A1 CA2016387 A1 CA 2016387A1
Authority
CA
Canada
Prior art keywords
pai
rpai
coli
val
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002016387A
Other languages
English (en)
French (fr)
Inventor
Thomas M. Reilly
William P. Sisk
Gary L. Davis
Robert M. Knabb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2016387A1 publication Critical patent/CA2016387A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8132—Plasminogen activator inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002016387A 1989-05-11 1990-05-09 High level expression of functional human plasminogen activator inhibitor (pai-1) in e. coli Abandoned CA2016387A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35026489A 1989-05-11 1989-05-11
US07/350,264 1989-05-11

Publications (1)

Publication Number Publication Date
CA2016387A1 true CA2016387A1 (en) 1990-11-11

Family

ID=23375938

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002016387A Abandoned CA2016387A1 (en) 1989-05-11 1990-05-09 High level expression of functional human plasminogen activator inhibitor (pai-1) in e. coli

Country Status (5)

Country Link
EP (1) EP0471759A1 (de)
JP (1) JPH04505252A (de)
AU (1) AU5649390A (de)
CA (1) CA2016387A1 (de)
WO (1) WO1990013648A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3742997A1 (de) * 1987-12-18 1989-06-29 Behringwerke Ag Peptide, verfahren zu ihrer herstellung, ihre verwendung zur gewinnung von antikoerpern sowie deren verwendung zur blockierung der pai-1-aktivitaet menschlichen blutes
EP1485709A4 (de) 2002-02-19 2005-09-21 Univ Vanderbilt Therapieverfahren mit pai-1-inhibitoren und transgenes nichtmenschliches tier zum screening von pai-1-inhibitorkandidaten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952512A (en) * 1984-06-22 1990-08-28 Loskutoff David J Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators

Also Published As

Publication number Publication date
EP0471759A1 (de) 1992-02-26
AU5649390A (en) 1990-11-29
JPH04505252A (ja) 1992-09-17
WO1990013648A1 (en) 1990-11-15

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Legal Events

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