CA2007507A1 - Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules - Google Patents
Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellulesInfo
- Publication number
- CA2007507A1 CA2007507A1 CA2007507A CA2007507A CA2007507A1 CA 2007507 A1 CA2007507 A1 CA 2007507A1 CA 2007507 A CA2007507 A CA 2007507A CA 2007507 A CA2007507 A CA 2007507A CA 2007507 A1 CA2007507 A1 CA 2007507A1
- Authority
- CA
- Canada
- Prior art keywords
- sphingosine
- methyl
- pharmaceutically acceptable
- prepared
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30637889A | 1989-02-03 | 1989-02-03 | |
US306,378 | 1989-02-03 | ||
US39013589A | 1989-08-07 | 1989-08-07 | |
US390,135 | 1989-08-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2007507A1 true CA2007507A1 (fr) | 1990-08-03 |
CA2007507C CA2007507C (fr) | 1998-05-19 |
Family
ID=26975128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002007507A Expired - Fee Related CA2007507C (fr) | 1989-02-03 | 1990-01-10 | Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0381514B1 (fr) |
JP (1) | JP2976055B2 (fr) |
AT (1) | ATE122560T1 (fr) |
CA (1) | CA2007507C (fr) |
DE (1) | DE69019388T2 (fr) |
DK (1) | DK0381514T3 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5583160A (en) * | 1989-02-03 | 1996-12-10 | The Biomembrane Institute | Methylsphingosine used to treat apoptosis |
US5151360A (en) * | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
US5260288A (en) * | 1992-04-03 | 1993-11-09 | The Biomembrane Institute | Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives |
IL121320A (en) | 1997-02-23 | 2000-12-06 | Ibr Ltd | Extracts from cells or tissue of organisms which are capable of entering dormancy for inhibition of proliferation of target cells or tissue |
US6107520A (en) * | 1997-04-15 | 2000-08-22 | The Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
US6800661B1 (en) | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
USRE38793E1 (en) | 1997-04-15 | 2005-09-06 | Rinehart Kenneth L | Spisulosine compounds |
AUPO900297A0 (en) * | 1997-09-08 | 1997-10-02 | Medvet Science Pty. Ltd. | A method of modulating cellular activity |
US6649362B2 (en) | 1997-09-08 | 2003-11-18 | Medvet Science Pty. Ltd. | Screening method for an agent having an effect on a sphingosine kinase signaling pathway |
JP2003523338A (ja) | 2000-02-16 | 2003-08-05 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍活性を有するオキシ−及びアミノ−置換テトラヒドロフリル誘導体 |
EP1195604A1 (fr) * | 2000-09-29 | 2002-04-10 | Warner-Lambert Company | Procedés et compositions pour la sondage de modulateurs de lipide kinases |
WO2002060405A1 (fr) * | 2001-01-29 | 2002-08-08 | Cosmoferm B.V. | Composition dermatologique veterinaire contenant une base sphingoide et/ou un derive de base sphingoide |
KR100457113B1 (ko) * | 2001-12-27 | 2004-11-16 | 한국원자력연구소 | 세라마이드류 또는 그 유도체와 다이메틸스핑고신을 유효성분으로 포함하는 방사선민감도 증진제 |
KR100459484B1 (ko) * | 2002-05-20 | 2004-12-03 | 한국원자력연구소 | 엔-아세틸 파이토스핑고신과 다이메틸 파이토스핑고신을유효 성분으로 포함하는 방사선 치료 민감제 조성물 |
EP1426053A1 (fr) * | 2002-12-03 | 2004-06-09 | Fresenius Kabi Deutschland GmbH | Utilisation de lipides amphiphiles pour l'inhibition de métastases |
ATE539741T1 (de) | 2004-11-30 | 2012-01-15 | Tno | Sphingolipide bei der behandlung und prävention von hepatischer steatose |
CN102892748A (zh) * | 2009-11-12 | 2013-01-23 | 德克萨斯理工大学 | 用于治疗过度增生性疾病的组合物和方法 |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
-
1990
- 1990-01-10 CA CA002007507A patent/CA2007507C/fr not_active Expired - Fee Related
- 1990-02-02 AT AT90301099T patent/ATE122560T1/de not_active IP Right Cessation
- 1990-02-02 DK DK90301099.9T patent/DK0381514T3/da active
- 1990-02-02 EP EP90301099A patent/EP0381514B1/fr not_active Expired - Lifetime
- 1990-02-02 DE DE69019388T patent/DE69019388T2/de not_active Expired - Fee Related
- 1990-02-02 JP JP2025010A patent/JP2976055B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69019388D1 (de) | 1995-06-22 |
DK0381514T3 (da) | 1995-09-04 |
EP0381514A2 (fr) | 1990-08-08 |
JPH03157336A (ja) | 1991-07-05 |
ATE122560T1 (de) | 1995-06-15 |
DE69019388T2 (de) | 1996-01-04 |
EP0381514A3 (fr) | 1991-07-17 |
JP2976055B2 (ja) | 1999-11-10 |
EP0381514B1 (fr) | 1995-05-17 |
CA2007507C (fr) | 1998-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |