CA2001194A1 - Utilisation de la resiniferatoxine et de ses analogues pour la desensibilisation thermo-regulatoire des fibres-c sensorielles afferentes - Google Patents

Utilisation de la resiniferatoxine et de ses analogues pour la desensibilisation thermo-regulatoire des fibres-c sensorielles afferentes

Info

Publication number
CA2001194A1
CA2001194A1 CA2001194A CA2001194A CA2001194A1 CA 2001194 A1 CA2001194 A1 CA 2001194A1 CA 2001194 A CA2001194 A CA 2001194A CA 2001194 A CA2001194 A CA 2001194A CA 2001194 A1 CA2001194 A1 CA 2001194A1
Authority
CA
Canada
Prior art keywords
resiniferatoxin
sensory afferent
thermoregulatory
desensitization
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2001194A
Other languages
English (en)
Other versions
CA2001194C (fr
Inventor
Peter M. Blumberg
Arpad Szallasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Commerce
Original Assignee
Peter M. Blumberg
The United States Of America, Represented By The Secretary, U.S. Departm Ent Of Commerce
Arpad Szallasi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter M. Blumberg, The United States Of America, Represented By The Secretary, U.S. Departm Ent Of Commerce, Arpad Szallasi filed Critical Peter M. Blumberg
Publication of CA2001194A1 publication Critical patent/CA2001194A1/fr
Application granted granted Critical
Publication of CA2001194C publication Critical patent/CA2001194C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
CA002001194A 1988-10-24 1989-10-23 Utilisation de la resiniferatoxine et de ses analogues pour la desensibilisation thermo-regulatoire des fibres-c sensorielles afferentes Expired - Fee Related CA2001194C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US261,627 1988-10-24
US07/261,627 US4939149A (en) 1988-10-24 1988-10-24 Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization

Publications (2)

Publication Number Publication Date
CA2001194A1 true CA2001194A1 (fr) 1990-04-24
CA2001194C CA2001194C (fr) 1995-12-05

Family

ID=22994143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002001194A Expired - Fee Related CA2001194C (fr) 1988-10-24 1989-10-23 Utilisation de la resiniferatoxine et de ses analogues pour la desensibilisation thermo-regulatoire des fibres-c sensorielles afferentes

Country Status (8)

Country Link
US (2) US4939149A (fr)
EP (1) EP0439549B1 (fr)
JP (1) JPH0729919B2 (fr)
AU (1) AU619930B2 (fr)
CA (1) CA2001194C (fr)
DE (1) DE68910834T2 (fr)
IL (1) IL92082A0 (fr)
WO (1) WO1990004389A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9044452B2 (en) 2004-12-28 2015-06-02 Mestex Ag Use of resiniferatoxin (RTX) for producing an agent for treating joint pains and method for applying said agent

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US5232684A (en) * 1990-06-29 1993-08-03 The United States Of America As Represented By The Department Of Health And Human Services Labelled resiniferatoxin, compositions thereof, and methods for using the same
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US6239180B1 (en) 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
US6248788B1 (en) 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
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EP1201241B8 (fr) † 1997-03-13 2010-10-27 James N. Campbell Compositions contenant de la capsaicine ou des analogues de capsaicine et un anesthésique
WO1999009970A1 (fr) * 1997-08-28 1999-03-04 Afferon Corporation Therapie contre l'incontinence urinaire
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US20110071468A1 (en) * 1998-06-04 2011-03-24 Mederi Therapeutics, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
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US20060240125A1 (en) * 2005-04-21 2006-10-26 Astrup Arne V Composition for affecting weight loss
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
EP1471910A2 (fr) * 2002-01-17 2004-11-03 Neurogen Corporation Analogues de quinazoline-4-ylamine substitues comme modulateurs de receptors de la capsaicin
DK1539124T3 (en) * 2002-09-05 2018-10-08 Vanderbilt Royalty Sub L P : COMPOSITIONS AND KITS FOR REMOVAL OF BODY SURFACES
EP2422773A3 (fr) 2002-09-20 2012-04-18 Alpharma, Inc. Séquestration de sous-unité et compositions et procédés associés
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US20040224037A1 (en) * 2003-04-28 2004-11-11 Gonzalo Romero-Matos Devastating treatment against hiv/aids with capsaicin
CA2529984C (fr) 2003-06-26 2012-09-25 Isa Odidi Capsules contenant un inhibiteur de la pompe a protons comprenant des unites secondaires differemment structurees permettant une liberation retardee de l'ingredient actif
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US8394409B2 (en) * 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
BRPI0516912A2 (pt) * 2004-11-24 2009-06-23 Algorx Pharmaceuticals Inc formulação a base do capsaicinoide em gel e usos da mesma
EP1871179B1 (fr) * 2005-01-28 2018-06-06 Archer Daniels Midland Company Compositions alimentaires pour animaux capables de reduire l'incidence de la toxicose de la fetuque chez des mammiferes
PT1865941E (pt) * 2005-04-01 2011-01-05 Neurogesx Inc Óleos de capsaicinóides e métodos para a sua produção e utilização
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JP5457830B2 (ja) * 2006-04-03 2014-04-02 オディディ，イサ オルガノゾル被膜を含む制御放出送達デバイス
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
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US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
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PL2826467T3 (pl) 2010-12-22 2018-01-31 Purdue Pharma Lp Zamknięte, zabezpieczone przed manipulowaniem formy dozowania o kontrolowanym uwalnianiu
ES2581323T3 (es) 2010-12-23 2016-09-05 Purdue Pharma Lp Formas de dosificación oral sólida resistentes a alteraciones
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AU5744490A (en) * 1989-05-15 1990-12-18 Afferon Corporation Composition and method for neural desensitization

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9044452B2 (en) 2004-12-28 2015-06-02 Mestex Ag Use of resiniferatoxin (RTX) for producing an agent for treating joint pains and method for applying said agent

Also Published As

Publication number Publication date
DE68910834T2 (de) 1994-03-17
CA2001194C (fr) 1995-12-05
DE68910834D1 (de) 1993-12-23
AU4624189A (en) 1990-05-14
EP0439549A4 (en) 1991-12-04
AU619930B2 (en) 1992-02-06
EP0439549A1 (fr) 1991-08-07
JPH03504387A (ja) 1991-09-26
US4939149A (en) 1990-07-03
WO1990004389A1 (fr) 1990-05-03
EP0439549B1 (fr) 1993-11-18
JPH0729919B2 (ja) 1995-04-05
IL92082A0 (en) 1990-07-12
US5290816A (en) 1994-03-01

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