CA1338319C - Derives de la cyclosporine avec 8-aminoacide modifie - Google Patents

Derives de la cyclosporine avec 8-aminoacide modifie

Info

Publication number
CA1338319C
CA1338319C CA 585752 CA585752A CA1338319C CA 1338319 C CA1338319 C CA 1338319C CA 585752 CA585752 CA 585752 CA 585752 A CA585752 A CA 585752A CA 1338319 C CA1338319 C CA 1338319C
Authority
CA
Canada
Prior art keywords
alanine
fluoro
deutero
cyclosporin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA 585752
Other languages
English (en)
Inventor
Arthur A. Patchett
Raymond F. White
Robert T. Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of CA1338319C publication Critical patent/CA1338319C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA 585752 1987-06-22 1988-12-13 Derives de la cyclosporine avec 8-aminoacide modifie Expired - Fee Related CA1338319C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22
US064,674 1987-06-22

Publications (1)

Publication Number Publication Date
CA1338319C true CA1338319C (fr) 1996-05-07

Family

ID=22057543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 585752 Expired - Fee Related CA1338319C (fr) 1987-06-22 1988-12-13 Derives de la cyclosporine avec 8-aminoacide modifie

Country Status (2)

Country Link
CA (1) CA1338319C (fr)
GB (1) GB2206119B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373260B1 (fr) * 1987-06-22 1994-03-09 Merck & Co. Inc. Dérivés de cyclosporine avec un acide aminé modifié en position 8
CH679119A5 (fr) * 1988-05-13 1991-12-31 Sandoz Ag
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
GB2227244A (en) * 1989-01-19 1990-07-25 Merck & Co Inc Immunosuppressive fluorinated cyclosporin analogs
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5214130A (en) * 1990-02-27 1993-05-25 Merck & Co., Inc. Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
JP3631490B2 (ja) 1992-05-13 2005-03-23 ノバルティス ファーマ株式会社 シクロスポリン含有眼科用組成物
PT589843E (pt) 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
EP0696323A1 (fr) * 1993-04-23 1996-02-14 Novartis AG Alanine racemase et gapdh du tolypocladium niveum recombines
DK0789580T3 (da) 1994-11-03 2002-09-09 Novartis Ag Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
EP0988046B1 (fr) 1997-01-30 2004-09-15 Novartis AG Compositions pharmaceutiques exemptes d'huile, a base de cyclosporine a
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
PL210841B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
NZ594755A (en) 2009-01-30 2013-12-20 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2012145427A1 (fr) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Méthodes de traitement du cancer à l'aide de cyclosporine et de dérivés de cyclosporine
WO2014085623A1 (fr) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Nouveaux analogues de [n-me-4-hydroxyleucine]-9-cyclosporine
AU2014311346A1 (en) 2013-08-26 2016-03-17 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C
WO2016073480A1 (fr) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Analogues de cyclosporine pour prévenir ou traiter une infection par l'hépatite c

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines

Also Published As

Publication number Publication date
GB2206119A (en) 1988-12-29
GB8814598D0 (en) 1988-07-27
GB2206119B (en) 1990-10-31

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