CA1336003C - Sels de pentamidine utiles pour le traitement et la prophylaxie de la pneumonie a pneumocystis carinii - Google Patents

Sels de pentamidine utiles pour le traitement et la prophylaxie de la pneumonie a pneumocystis carinii

Info

Publication number
CA1336003C
CA1336003C CA000582326A CA582326A CA1336003C CA 1336003 C CA1336003 C CA 1336003C CA 000582326 A CA000582326 A CA 000582326A CA 582326 A CA582326 A CA 582326A CA 1336003 C CA1336003 C CA 1336003C
Authority
CA
Canada
Prior art keywords
pentamidine
salt
acid
formulation
lactate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000582326A
Other languages
English (en)
Inventor
Abu S. Alam
Sadanand Pai
John N. Kapoor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abraxis Bioscience LLC
Original Assignee
Lyphomed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyphomed Inc filed Critical Lyphomed Inc
Application granted granted Critical
Publication of CA1336003C publication Critical patent/CA1336003C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/265—Citric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000582326A 1987-11-06 1988-11-04 Sels de pentamidine utiles pour le traitement et la prophylaxie de la pneumonie a pneumocystis carinii Expired - Fee Related CA1336003C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11828487A 1987-11-06 1987-11-06
US118,284 1987-11-06

Publications (1)

Publication Number Publication Date
CA1336003C true CA1336003C (fr) 1995-06-20

Family

ID=22377637

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000582326A Expired - Fee Related CA1336003C (fr) 1987-11-06 1988-11-04 Sels de pentamidine utiles pour le traitement et la prophylaxie de la pneumonie a pneumocystis carinii

Country Status (14)

Country Link
EP (1) EP0315467A3 (fr)
JP (1) JPH02150A (fr)
KR (1) KR970008156B1 (fr)
CN (1) CN1020897C (fr)
AU (1) AU618762B2 (fr)
BR (1) BR8805759A (fr)
CA (1) CA1336003C (fr)
DK (1) DK616088A (fr)
FI (1) FI885020A (fr)
GR (1) GR1000263B (fr)
IL (1) IL88159A (fr)
IN (1) IN168530B (fr)
MX (1) MX13665A (fr)
NO (1) NO171723C (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3872635T2 (de) * 1987-04-09 1992-12-17 Fisons Plc Pentamidin enthaltende pharmazeutische zusammensetzungen.
US5366726A (en) * 1987-12-23 1994-11-22 The Regents Of The University Of California Suppression of Pneumocystis carinii using aerosolized pentamidine treatment
US5364615A (en) * 1987-12-23 1994-11-15 Regents Of The University Of California Prophylaxis of pneumocystis carinii with aerosilized pentamidine
US5807572A (en) * 1988-02-18 1998-09-15 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
DE3851951T2 (de) * 1988-03-31 1995-02-23 Orbisphere Lab Inc Wilmington Amperometrische Messmethode Amperometrische Messmethode.
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DE4122744C2 (de) * 1990-08-06 1994-02-03 Nattermann A & Cie Wäßriges Liposomensystem und Verfahren zu seiner Herstellung
DE4108903A1 (de) * 1990-08-06 1992-02-13 Nattermann A & Cie Pharmazeutisches produkt
US5556637A (en) * 1990-08-06 1996-09-17 A. Nattermann & Cie. Gmbh Water containing liposome system
DE4122661C2 (de) * 1990-08-06 1996-07-11 Nattermann A & Cie Pharmazeutisches Produkt zur Behandlung von Pneumocystis-carinii-Pneumonie
US6663885B1 (en) 1993-03-15 2003-12-16 A. Natterman & Cie Gmbh Aqueous liposome system and a method for the preparation of such a liposome system
NZ276305A (en) * 1993-11-16 1997-10-24 Depotech Corp Controlled release vesicle compositions
CA2205112C (fr) * 1995-09-19 2008-11-18 Cellular Sciences, Inc. Methode et composition de traitement de maladies mammaliennes provoquees par une reaction inflammatoire
KR100219601B1 (ko) * 1996-05-15 1999-09-01 윤종용 인쇄면 판별영역을 갖는 ohp 및 승화형 열전사 프린터의 ohp 인쇄면 판별 방법 및 이에 적합한 장치
DE10149919A1 (de) * 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
JP3972876B2 (ja) * 2003-09-03 2007-09-05 日産自動車株式会社 エンジンの燃料カット制御装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2410796A (en) * 1942-04-11 1946-11-05 May & Baker Ltd Soluble amidine salts
US2425221A (en) * 1942-07-27 1947-08-05 May & Baker Ltd Production of amidine salts
GB575145A (en) * 1944-02-23 1946-02-05 May & Baker Ltd Improvements in or relating to the preparation of amidine salts
AU620025B2 (en) * 1987-03-26 1992-02-13 Sloan-Kettering Institute For Cancer Research Method of preventing pneumocystis carinii pneumonia using pentamidine in an aerosol form

Also Published As

Publication number Publication date
EP0315467A2 (fr) 1989-05-10
JPH02150A (ja) 1990-01-05
CN1020897C (zh) 1993-05-26
NO884881L (no) 1989-05-08
DK616088A (da) 1989-05-07
IL88159A0 (en) 1989-06-30
KR890007723A (ko) 1989-07-05
DK616088D0 (da) 1988-11-04
FI885020A0 (fi) 1988-11-01
NO171723B (no) 1993-01-18
IL88159A (en) 1994-04-12
IN168530B (fr) 1991-04-20
AU2447688A (en) 1989-05-11
FI885020A (fi) 1989-05-07
CN1033046A (zh) 1989-05-24
NO884881D0 (no) 1988-11-02
AU618762B2 (en) 1992-01-09
BR8805759A (pt) 1989-07-25
EP0315467A3 (fr) 1990-09-26
NO171723C (no) 1993-04-28
GR1000263B (el) 1992-05-12
MX13665A (es) 1993-12-01
KR970008156B1 (ko) 1997-05-21

Similar Documents

Publication Publication Date Title
CA1336003C (fr) Sels de pentamidine utiles pour le traitement et la prophylaxie de la pneumonie a pneumocystis carinii
US4829088A (en) Medicament for the treatment of inflammations of the eye
EP0664703B1 (fr) Methodes pour lutter contre la pneumonie (pneumocystis carinii) et composes utiles a cet effet
JP2645427B2 (ja) 混合ミセル溶液
US6645522B2 (en) Erythropoietin liposomal dispersion
HU186296B (en) Process for producing parenteral pharmaceutical compositions
JPH08268893A (ja) スタウロスポリン誘導体の静脈内投与のための医薬組成物
US5283067A (en) Parenteral suspensions
JPH03181422A (ja) 炎症の治療方法及び炎症の治療用合成薬
US5942510A (en) Pharmaceutical composition containing lamotrigine
EP0225162B1 (fr) Inhibition de la formation de l'adhérence postchirurgicale par l'administration topique d'un médicament anti-inflammatoire non stéroide
US5084480A (en) Pentamidine salts useful in the treatment of pneumocystis carinii pneumonia
EP0345926B1 (fr) Compositions pharmaceutiques contenant de la pentamidine
IE60453B1 (en) Parenteral suspensions of diclofenac
US4889862A (en) Freeze-dried pharmaceutical compositions of phenylquinoline carboxylic acids
US6194401B1 (en) Pharmaceutical compositions containing cyclosporine and a carrier comprising at least an ester of α-glycerophosphoric acid
US4481210A (en) Method of treatment

Legal Events

Date Code Title Description
MKLA Lapsed