CA1334975C - Furan and pyrrole containing lipoxygenase inhibiting compounds - Google Patents
Furan and pyrrole containing lipoxygenase inhibiting compoundsInfo
- Publication number
- CA1334975C CA1334975C CA000582806A CA582806A CA1334975C CA 1334975 C CA1334975 C CA 1334975C CA 000582806 A CA000582806 A CA 000582806A CA 582806 A CA582806 A CA 582806A CA 1334975 C CA1334975 C CA 1334975C
- Authority
- CA
- Canada
- Prior art keywords
- hydroxy
- urea
- ethyl
- alkyl
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11992687A | 1987-11-13 | 1987-11-13 | |
US119,926 | 1987-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1334975C true CA1334975C (en) | 1995-03-28 |
Family
ID=22387222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000582806A Expired - Fee Related CA1334975C (en) | 1987-11-13 | 1988-11-10 | Furan and pyrrole containing lipoxygenase inhibiting compounds |
Country Status (8)
Country | Link |
---|---|
US (1) | US5112848A (ja) |
EP (2) | EP0320628B1 (ja) |
JP (1) | JP2545145B2 (ja) |
KR (1) | KR970005906B1 (ja) |
AU (1) | AU614807B2 (ja) |
CA (1) | CA1334975C (ja) |
DE (1) | DE3855757D1 (ja) |
WO (1) | WO1989004299A1 (ja) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
US4960787A (en) * | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
US5118708A (en) * | 1989-06-23 | 1992-06-02 | Norwich Eaton Pharmaceuticals, Inc. | Use of 5-phenyl-2-furan esters, amides and ketones as neuroprotective agents |
PH30133A (en) * | 1989-09-07 | 1997-01-21 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing lipoxygenase inhibiting compounds |
GB9012252D0 (en) * | 1990-06-01 | 1990-07-18 | Lilly Industries Ltd | Pharmaceutical compounds |
US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
ATE144247T1 (de) * | 1990-07-25 | 1996-11-15 | Abbott Lab | Acetylenderivate mit lipoxygenase inhibitorischer wirkung |
US5132319A (en) * | 1991-03-28 | 1992-07-21 | Merck Frosst Canada, Inc. | 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis |
US5128364A (en) * | 1991-03-28 | 1992-07-07 | Merck Frosst Canada, Inc. | Pyrrolo[1,2-a]indole hydroxylamine derivatives as inhibitors of leukotriene biosynthesis |
US5214204A (en) * | 1991-07-19 | 1993-05-25 | Abbott Laboratories | Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity |
DE4125270A1 (de) * | 1991-07-31 | 1993-02-04 | Bayer Ag | Chinolin-2-yl-methoxybenzylhydroxyharnstoffe |
US5234933A (en) * | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
US5169854A (en) * | 1992-02-26 | 1992-12-08 | Abbott Laboratories | N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity |
US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
ES2152952T3 (es) | 1992-07-13 | 2001-02-16 | Millennium Pharm Inc | 2,5-diaril tetrahidro-tiofenos, -furanos y analogos para el tratamiento de problemas inflamatorios e inmunes. |
JP2738486B2 (ja) * | 1992-11-20 | 1998-04-08 | ファイザー製薬株式会社 | 抗炎症剤としての新規なイソオキサゾリン類 |
US5292900A (en) * | 1992-12-18 | 1994-03-08 | Abbott Laboratories | O-substituted N-hydroxyurea derivatives |
DE69421183T2 (de) * | 1993-07-20 | 2000-01-20 | Pfizer | Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe |
US5506261A (en) * | 1994-05-09 | 1996-04-09 | Abbott Laboratories | Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US6201016B1 (en) | 1994-06-27 | 2001-03-13 | Cytomed Incorporated | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5612377A (en) * | 1994-08-04 | 1997-03-18 | Minnesota Mining And Manufacturing Company | Method of inhibiting leukotriene biosynthesis |
US5516789A (en) * | 1995-04-12 | 1996-05-14 | Abbott Laboratories | Lipoxygenase and cyclooxygenase inhibiting compounds |
US5792778A (en) * | 1995-08-10 | 1998-08-11 | Merck & Co., Inc. | 2-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5837719A (en) * | 1995-08-10 | 1998-11-17 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
US5908858A (en) | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
CA2345919A1 (en) | 1998-07-03 | 2000-01-13 | Gangavaram Vasantha Madhava Sharma | Substituted oxygen alicyclic compounds, including methods for synthesis thereof |
WO2000001683A1 (en) | 1998-07-03 | 2000-01-13 | Leukosite, Inc. | Methods for synthesis of substituted tetrahydrofuran compound |
US6255498B1 (en) | 1998-10-16 | 2001-07-03 | Millennium Pharmaceuticals, Inc. | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans |
KR20010089708A (ko) | 1998-12-25 | 2001-10-08 | 시오노 요시히코 | Hiv 인테그라제 저해 활성을 갖는 방향족 복소환 유도체 |
KR100836547B1 (ko) | 2002-01-11 | 2008-06-10 | 상꾜 가부시키가이샤 | 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물 |
BRPI0507944A (pt) | 2004-02-24 | 2007-07-24 | Sankyo Co | composição farmacêutica |
AU2008274941A1 (en) | 2007-07-12 | 2009-01-15 | Tragara Pharmaceuticals, Inc. | Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders |
BRPI1014405A2 (pt) | 2009-04-29 | 2016-04-05 | Amarin Corp Plc | composições farmacêuticas compreendendo epa e um agente cardiovascular e métodos de seu uso |
CA2926950C (en) | 2013-10-10 | 2022-10-11 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664397A (en) * | 1966-03-09 | 1972-05-23 | American Kitchen Foods Inc | Apparatus and method for detecting and processing materials according to color or shade variations thereon |
US3982922A (en) * | 1967-12-28 | 1976-09-28 | Velsicol Chemical Corporation | Herbicidal compositions containing furancarboxamides |
US3644397A (en) * | 1968-11-12 | 1972-02-22 | Richardson Merrell Inc | Substituted 2-aminomethylpyrroles |
JPS5234623B2 (ja) * | 1971-12-29 | 1977-09-05 | ||
JPS50100196U (ja) * | 1974-01-17 | 1975-08-19 | ||
US4048191A (en) * | 1975-06-27 | 1977-09-13 | Mcneil Laboratories, Incorporated | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds |
US4185020A (en) * | 1979-02-07 | 1980-01-22 | Morton-Norwich Products, Inc. | 5-(4-Nitrophenyl)-2-furanmethanamines derivatives |
DE3012836C2 (de) * | 1980-04-02 | 1985-09-26 | Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt | Einrichtung zum Festspannen der Schleifscheibe von Winkelschleifern |
US4332952A (en) * | 1980-07-28 | 1982-06-01 | Pfizer Inc. | Hypoglycemic 5-substituted oxazolidine-2,4-diones |
DE3686733T2 (de) * | 1985-03-16 | 1993-02-11 | Wellcome Found | Aryl-derivate. |
JPS61191870U (ja) * | 1985-05-23 | 1986-11-29 | ||
GB8609452D0 (en) * | 1986-04-17 | 1986-05-21 | Ici Plc | Fungicides |
US4826868A (en) * | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
US4717413A (en) * | 1986-12-15 | 1988-01-05 | Stauffer Chemical Company | N-carbonyl-N-(2-furfuryl)-4-haloanilines and herbicidal use thereof |
EP0279263B1 (en) * | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
DE3855567T2 (de) * | 1987-07-20 | 1997-02-06 | Matsushita Electric Ind Co Ltd | Übertragungssystem |
-
1988
- 1988-11-10 CA CA000582806A patent/CA1334975C/en not_active Expired - Fee Related
- 1988-11-14 DE DE3855757T patent/DE3855757D1/de not_active Expired - Lifetime
- 1988-11-14 EP EP88118921A patent/EP0320628B1/en not_active Expired - Lifetime
- 1988-11-14 KR KR1019890701315A patent/KR970005906B1/ko active IP Right Grant
- 1988-11-14 US US07/487,982 patent/US5112848A/en not_active Expired - Fee Related
- 1988-11-14 EP EP19890900094 patent/EP0388429A4/en active Pending
- 1988-11-14 AU AU28035/89A patent/AU614807B2/en not_active Ceased
- 1988-11-14 WO PCT/US1988/004048 patent/WO1989004299A1/en not_active Application Discontinuation
- 1988-11-14 JP JP1500207A patent/JP2545145B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1989004299A1 (en) | 1989-05-18 |
JPH03500887A (ja) | 1991-02-28 |
AU2803589A (en) | 1989-06-01 |
US5112848A (en) | 1992-05-12 |
EP0320628B1 (en) | 1997-01-15 |
AU614807B2 (en) | 1991-09-12 |
EP0320628A1 (en) | 1989-06-21 |
KR970005906B1 (ko) | 1997-04-22 |
KR890701557A (ko) | 1989-12-20 |
EP0388429A1 (en) | 1990-09-26 |
JP2545145B2 (ja) | 1996-10-16 |
EP0388429A4 (en) | 1991-08-21 |
DE3855757D1 (de) | 1997-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKLA | Lapsed |