CA1324129C - Prostaglandins of the f series - Google Patents

Prostaglandins of the f series

Info

Publication number
CA1324129C
CA1324129C CA000565406A CA565406A CA1324129C CA 1324129 C CA1324129 C CA 1324129C CA 000565406 A CA000565406 A CA 000565406A CA 565406 A CA565406 A CA 565406A CA 1324129 C CA1324129 C CA 1324129C
Authority
CA
Canada
Prior art keywords
dihydro
keto
alkyl group
pgfs
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000565406A
Other languages
English (en)
French (fr)
Inventor
Ryuzo Ueno
Ryuji Ueno
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of CA1324129C publication Critical patent/CA1324129C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CA000565406A 1987-04-30 1988-04-28 Prostaglandins of the f series Expired - Lifetime CA1324129C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP10752987 1987-04-30
JP107529/1987 1987-04-30
JP23589087 1987-09-18
JP235890/1987 1987-09-18

Publications (1)

Publication Number Publication Date
CA1324129C true CA1324129C (en) 1993-11-09

Family

ID=26447552

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000565406A Expired - Lifetime CA1324129C (en) 1987-04-30 1988-04-28 Prostaglandins of the f series

Country Status (11)

Country Link
US (1) US5106869A (en:Method)
EP (1) EP0289349B1 (en:Method)
JP (1) JPH0667900B2 (en:Method)
KR (1) KR930006202B1 (en:Method)
AT (1) ATE72235T1 (en:Method)
CA (1) CA1324129C (en:Method)
DE (2) DE3868127D1 (en:Method)
ES (1) ES2032016T3 (en:Method)
GR (1) GR3003749T3 (en:Method)
NL (1) NL300135I2 (en:Method)
ZA (1) ZA886909B (en:Method)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE108330T1 (de) * 1987-09-18 1994-07-15 R Tech Ueno Ltd Hypotensive okulare mittel.
JP2597629B2 (ja) * 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP1348437A3 (en) * 1988-09-06 2003-11-19 Pharmacia Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5234954A (en) * 1989-07-27 1993-08-10 K.K. Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
ATE122563T1 (de) * 1989-07-27 1995-06-15 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von 15-keto-prostansäure-derivaten zur herstellung eines medikaments für die verbesserung der ausscheidung des kaliumions.
EP0415564B1 (en) * 1989-08-09 1995-04-26 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Use of prostanoic acid derivaties for the manufacture of a medicament for improvement of excretion of nonprotein nitrogen into the intestine
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
US5256696A (en) * 1989-11-22 1993-10-26 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds
US5254588A (en) * 1989-11-22 1993-10-19 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
TW224942B (en:Method) * 1990-04-04 1994-06-11 Adka Ueno Kk
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ES2093774T3 (es) * 1991-03-14 1997-01-01 R Tech Ueno Ltd Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
CA2065889C (en) * 1991-10-02 2002-08-27 Tetsuya Sugiyama Increasing the choroidal blood flow
DE69311361T2 (de) * 1992-10-13 1998-01-08 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
HU223345B1 (hu) 1995-12-20 2004-08-30 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Eljárás alfa, béta-telítetlen ketonok sztereoszelektív redukciójára
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US6770675B2 (en) 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
SK3382000A3 (en) * 1997-09-09 2000-10-09 Procter & Gamble A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders
TWI225398B (en) * 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
US6576663B2 (en) 1999-12-22 2003-06-10 Alcon, Inc. 6-Keto prostaglandin F1α and analogs for treating dry eye
AU2003257588A1 (en) * 2002-08-29 2004-03-19 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND PROSTAGLANDINS
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
KR20120005052A (ko) 2003-08-21 2012-01-13 수캄포 아게 안과용 조성물
KR101091461B1 (ko) 2003-11-07 2011-12-07 센주 세이야꾸 가부시키가이샤 프로스타글란딘 함유 의약 조성물
WO2006070942A1 (en) * 2004-12-29 2006-07-06 R-Tech Ueno, Ltd Composition and method for scalp and hair treatment
RU2420291C3 (ru) * 2006-01-24 2020-07-21 Р-Тек Уено, Лтд. Состав в мягкой желатиновой капсуле
CA2645311C (en) 2006-03-13 2014-11-18 R-Tech Ueno, Ltd. Aqueous composition comprising 15-keto-prostaglandin for ophthalmic use
WO2012137987A1 (en) 2011-04-07 2012-10-11 Sucampo Ag Method for treating asthenopia
AU2012293157A1 (en) 2011-08-05 2014-03-13 Sucampo Ag Method for treating schizophrenia
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
JP6162646B2 (ja) * 2014-05-27 2017-07-12 信越化学工業株式会社 ３，５−ジメチルドデカン酸の製造方法
US20170020890A1 (en) 2015-06-19 2017-01-26 Sucampo Ag Pharmaceutical composition comprising fatty acid derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505386A (en) * 1965-12-29 1970-04-07 Upjohn Co Compounds related to prostaglandins
US3984455A (en) * 1973-07-16 1976-10-05 The Upjohn Company Prostaglandin E1 analogs
GB1476661A (en) * 1974-05-13 1977-06-16 American Cyanamid Co Prostaglandins
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
JPS60208917A (ja) * 1984-02-29 1985-10-21 ジ・アツプジヨン・カンパニー Ａｒｄｓおよび多器官不全治療、予防におけるプロスタグランジンの使用
CA1323364C (en) * 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
FR2613722B1 (fr) * 1987-04-07 1990-11-23 Bp Chimie Sa Procede de fabrication de granules d'homopolymere ou de copolymere de propylene

Also Published As

Publication number Publication date
NL300135I2 (nl) 2004-05-03
ZA886909B (en) 1989-05-30
ES2032016T3 (es) 1993-01-01
DE3868127D1 (de) 1992-03-12
DE10399038I2 (de) 2004-09-23
JPH01151552A (ja) 1989-06-14
KR930006202B1 (ko) 1993-07-08
NL300135I1 (nl) 2003-12-01
GR3003749T3 (en:Method) 1993-03-16
EP0289349A1 (en) 1988-11-02
DE10399038I1 (de) 2004-05-06
JPH0667900B2 (ja) 1994-08-31
US5106869A (en) 1992-04-21
EP0289349B1 (en) 1992-01-29
ATE72235T1 (de) 1992-02-15
KR880012540A (ko) 1988-11-28

Similar Documents

Publication Publication Date Title
EP0289349B1 (en) Prostaglandins of the f series
US5221763A (en) Prostaglandins of the F series
US5770759A (en) Prostaglandins of the F series
US5073569A (en) Prostaglandins of the d series, and tranquilizers and soporifics containing the same
KR100260573B1 (ko) 간담즙성 질병 치료제
CA2030345C (en) Use of 15-keto-prostaglandin compound for improvement of encephalic function
EP0455264B1 (en) Ocular hypotensive agents
JP2597649B2 (ja) 気管・気管支拡張剤
KR970005174B1 (ko) 15-케토-프로스타글란딘 화합물을 사용한 췌장 질병의 치료
EP0284180A1 (en) Prostaglandins E and anti ulcers containing same
US5491254A (en) Prostaglandin derivatives
IE47549B1 (en) Acetyleneprostaglandins and process for their production
JPS5948822B2 (ja) Ｚ−デカルボキシ−２−ヒドロキシメチルｐｇｆ型化合物
JP3183615B2 (ja) 肝・胆道系疾患処置剤
JPH038338B2 (en:Method)
JPS609711B2 (ja) ９−デオキシ−９−メチレンｐｇｆ類似体類
US4208428A (en) Prostaglandin analogues
KR840000964B1 (ko) 15-설폰아미도프로스타글란딘 유도체의 제조방법
JPS6126970B2 (en:Method)
AU604156B2 (en) Prostaglandins of the F series
NZ226199A (en) 13,14-dihydro-15-keto-pgf derivatives and pharmaceutical compositions
GB2225573A (en) 13,14-dihydro-15-keto-PGFs
JPS5852992B2 (ja) ２ａ，２ｂ−ジホモ−１５メチルＰＧＦｚｘ誘導体の製法
JPH0296528A (ja) 眼圧降下剤
US4070537A (en) 17-Oxo-17-phenyl-prostaglandins

Legal Events

Date Code Title Description
MKEX Expiry

Effective date: 20101109