CA1321194C - Benzazepine and benzazepinone derivatives - Google Patents

Benzazepine and benzazepinone derivatives

Info

Publication number
CA1321194C
CA1321194C CA000523713A CA523713A CA1321194C CA 1321194 C CA1321194 C CA 1321194C CA 000523713 A CA000523713 A CA 000523713A CA 523713 A CA523713 A CA 523713A CA 1321194 C CA1321194 C CA 1321194C
Authority
CA
Canada
Prior art keywords
group
dimethoxy
compound
methoxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000523713A
Other languages
English (en)
French (fr)
Inventor
Manfred Psiorz
Joachim Heider
Andreas Bomhard
Manfred Reiffen
Norbert Hauel
Klaus Noll
Berthold Narr
Christian Lillie
Walter Kobinger
Jurgen Dammgen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of CA1321194C publication Critical patent/CA1321194C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000523713A 1985-11-27 1986-11-25 Benzazepine and benzazepinone derivatives Expired - Lifetime CA1321194C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3541811.7 1985-11-27
DE19853541811 DE3541811A1 (de) 1985-11-27 1985-11-27 Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CA1321194C true CA1321194C (en) 1993-08-10

Family

ID=6286902

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000523713A Expired - Lifetime CA1321194C (en) 1985-11-27 1986-11-25 Benzazepine and benzazepinone derivatives

Country Status (25)

Country Link
EP (1) EP0224794B1 (pt-PT)
JP (1) JPH0625128B2 (pt-PT)
KR (1) KR950007589B1 (pt-PT)
AT (1) ATE56447T1 (pt-PT)
AU (1) AU589712B2 (pt-PT)
CA (1) CA1321194C (pt-PT)
CZ (1) CZ410391A3 (pt-PT)
DD (1) DD256132A5 (pt-PT)
DE (2) DE3541811A1 (pt-PT)
DK (1) DK174564B1 (pt-PT)
ES (1) ES2018152B3 (pt-PT)
FI (1) FI88299C (pt-PT)
GR (1) GR3001107T3 (pt-PT)
HK (1) HK123993A (pt-PT)
HU (1) HU196787B (pt-PT)
IE (1) IE59487B1 (pt-PT)
IL (1) IL80758A (pt-PT)
MX (1) MX9202813A (pt-PT)
NO (1) NO168034C (pt-PT)
NZ (1) NZ218412A (pt-PT)
PH (1) PH22944A (pt-PT)
PT (1) PT83815B (pt-PT)
SU (1) SU1442073A3 (pt-PT)
UA (1) UA8034A1 (pt-PT)
ZA (1) ZA868933B (pt-PT)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524701B2 (en) 2002-07-25 2013-09-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
US8741350B2 (en) 2011-08-12 2014-06-03 Boehringer Ingelheim Vetmedica Gmbh Taste masked pharmaceutical composition

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1298427C (en) * 1987-03-13 1992-03-31 Johannes Adrianus Maria Van Broekhoven Process for removing palladium catalyst remnants from copolymers of carbon monoxide with one or more olefinically unsaturated compounds
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2634207B1 (fr) * 1988-07-12 1990-09-07 Synthelabo Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
DE10018401A1 (de) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
PT1362590E (pt) * 2002-07-25 2004-05-31 Boehringer Ingelheim Pharma Utilizacao de cilobradina ou dos seus sais farmaceuticamente aceitaveis para o tratamento ou prevencao de falha cardiaca
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
WO2014122248A1 (en) 2013-02-11 2014-08-14 Boehringer Ingelheim Vetmedica Gmbh Kit-of-parts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639718A1 (de) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K Neue phenylaethylamine
CH645632A5 (en) * 1977-01-01 1984-10-15 Thomae Gmbh Dr K Arylalkylamines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524701B2 (en) 2002-07-25 2013-09-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
US8741350B2 (en) 2011-08-12 2014-06-03 Boehringer Ingelheim Vetmedica Gmbh Taste masked pharmaceutical composition
US9289390B2 (en) 2011-08-12 2016-03-22 Boehringer Ingelheim Vetmedica Gmbh Taste masked pharmaceutical composition

Also Published As

Publication number Publication date
DE3674159D1 (de) 1990-10-18
UA8034A1 (uk) 1995-12-26
JPS62138491A (ja) 1987-06-22
EP0224794B1 (de) 1990-09-12
SU1442073A3 (ru) 1988-11-30
DD256132A5 (de) 1988-04-27
DK568386D0 (da) 1986-11-26
DK174564B1 (da) 2003-06-10
PH22944A (en) 1989-02-03
FI88299C (fi) 1993-04-26
ES2018152B3 (es) 1991-04-01
NO864744D0 (no) 1986-11-26
NO168034C (no) 1992-01-08
CZ410391A3 (en) 1993-03-17
HU196787B (en) 1989-01-30
HUT43056A (en) 1987-09-28
PT83815B (pt) 1989-06-30
NZ218412A (en) 1989-05-29
GR3001107T3 (en) 1992-05-12
HK123993A (en) 1993-11-19
AU6576486A (en) 1987-06-04
EP0224794A2 (de) 1987-06-10
IE863110L (en) 1987-05-27
NO168034B (no) 1991-09-30
PT83815A (de) 1986-12-01
IL80758A (en) 1991-01-31
AU589712B2 (en) 1989-10-19
FI88299B (fi) 1993-01-15
ZA868933B (en) 1988-07-27
DE3541811A1 (de) 1987-06-04
KR950007589B1 (ko) 1995-07-12
FI864785A0 (fi) 1986-11-25
IL80758A0 (en) 1987-02-27
EP0224794A3 (en) 1988-10-19
IE59487B1 (en) 1994-03-09
ATE56447T1 (de) 1990-09-15
KR870004973A (ko) 1987-06-02
DK568386A (da) 1987-05-28
MX9202813A (es) 1992-06-30
FI864785A (fi) 1987-05-28
JPH0625128B2 (ja) 1994-04-06

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Legal Events

Date Code Title Description
MKEX Expiry

Effective date: 20100810