CA1291123C - Heavy metal salts of hyaluronic acid useful as antimicrobial agents - Google Patents

Heavy metal salts of hyaluronic acid useful as antimicrobial agents

Info

Publication number
CA1291123C
CA1291123C CA000531936A CA531936A CA1291123C CA 1291123 C CA1291123 C CA 1291123C CA 000531936 A CA000531936 A CA 000531936A CA 531936 A CA531936 A CA 531936A CA 1291123 C CA1291123 C CA 1291123C
Authority
CA
Canada
Prior art keywords
silver
hyaluronate
hyaluronic acid
compound
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000531936A
Other languages
English (en)
French (fr)
Inventor
Abraham Nimrod
Benjamin Greenman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/840,419 external-priority patent/US4746504A/en
Priority claimed from US07/023,666 external-priority patent/US4784991A/en
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Application granted granted Critical
Publication of CA1291123C publication Critical patent/CA1291123C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000531936A 1986-03-14 1987-03-13 Heavy metal salts of hyaluronic acid useful as antimicrobial agents Expired - Fee Related CA1291123C (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US06/840,419 US4746504A (en) 1986-03-14 1986-03-14 Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
US840,419 1986-03-14
US1947487A 1987-02-26 1987-02-26
US019,474 1987-02-26
US023,666 1987-03-09
US07/023,666 US4784991A (en) 1986-03-14 1987-03-09 Heavy metal salts of hyaluronic acid and their use as antimicrobial agents

Publications (1)

Publication Number Publication Date
CA1291123C true CA1291123C (en) 1991-10-22

Family

ID=27361231

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000531936A Expired - Fee Related CA1291123C (en) 1986-03-14 1987-03-13 Heavy metal salts of hyaluronic acid useful as antimicrobial agents

Country Status (4)

Country Link
EP (1) EP0259485A4 (de)
AU (1) AU600483B2 (de)
CA (1) CA1291123C (de)
WO (1) WO1987005517A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145841A (en) * 1987-03-19 1992-09-08 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions
HU203372B (en) * 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
DE4115454A1 (de) * 1991-05-11 1992-11-12 Basf Ag Eisen-(iii)-hyaluronate
EP0852501B1 (de) * 1995-09-28 2004-12-01 Sangstat Medical Corporation Verwendung von hyaluronsäure als immunsuppessor
HU225991B1 (en) * 1997-04-29 2008-02-28 Richter Gedeon Nyrt Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
JP2003089647A (ja) * 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
NZ524076A (en) * 2000-07-31 2004-07-30 Dermal Res Lab Inc Preventing or treating diseases associated with allergies, autoimmunity and adhesion, metastatic and coronary cascades using complex carbohydrates, in particular hyaluronic acid
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
CA2495541C (en) 2002-09-11 2011-07-12 Johnson & Johnson Medical Limited Wound dressing materials comprising complexes of anionic polysaccharides with silver
CA2529413C (en) * 2003-06-20 2014-05-27 Johnson & Johnson Medical Limited Antioxidant wound dressing materials
GB2408206B (en) 2003-11-18 2007-11-28 Johnson & Johnson Medical Ltd Antioxidant and antimicrobial wound dressing materials
GB2402880B (en) * 2003-06-20 2008-01-23 Johnson & Johnson Medical Ltd Antimicrobial compositions comprising silver
US8425926B2 (en) 2003-07-16 2013-04-23 Yongxing Qiu Antimicrobial medical devices
ES2622834T3 (es) * 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos
TWI516269B (zh) 2009-08-14 2016-01-11 禾伸堂生技股份有限公司 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
TWI383796B (zh) 2009-08-14 2013-02-01 Holy Stone Healthcare Co Ltd Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
US8575130B2 (en) 2010-01-04 2013-11-05 Holy Stone Healthcare Co., Ltd. Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease
US8722644B2 (en) 2010-01-04 2014-05-13 Holy Stone Healthcare Co., Ltd. Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
US9029347B2 (en) 2010-08-05 2015-05-12 Holy Stone Healthcare Co., Ltd. Method and mixture for treating and preventing inflammatory bowel disease
IT1402786B1 (it) * 2010-11-19 2013-09-18 Fidia Farmaceutici Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante
CN102552309B (zh) * 2010-12-15 2013-06-05 北京理工大学 一种透明质酸金的用途及其制备方法
HUE037474T2 (hu) 2011-07-07 2018-08-28 Holy Stone Healthcare Co Ltd Készítmény gyulladással kapcsolatban rendellenesség kezelésében és megelõzésében történõ alkalmazásra
EP2545925B1 (de) 2011-07-12 2018-02-14 Holy Stone Healthcare Co.,Ltd. Zusammensetzung enthaltend Hyaluronsäure zur Behandlung und Verhinderung von Schleimhauterkrankungen
FR2978664B1 (fr) 2011-08-04 2014-01-10 Petcare Innovation Composition antiseptique
CZ303722B6 (cs) * 2012-01-16 2013-04-03 Contipro Biotech S.R.O. Kyselina hyaluronová znacená tritiem, zpusob znacení kyseliny hyaluronové tritiem a její pouzití
BR112014019795A8 (pt) * 2012-02-17 2017-07-11 Kimflexor S L Sal metálico de glicosaminoglicano parcialmente despolimerizado, seu processo de preparação, seus usos e composição farmacêutica ou cosmética
FR3002452B1 (fr) 2013-02-28 2016-02-12 Dermaconcept Jmc Composition dermatologique antimicrobienne topique
CN112500505A (zh) * 2020-11-19 2021-03-16 徐州医科大学 一种高分子银复合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172128A (en) * 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4211769A (en) * 1977-08-24 1980-07-08 Takeda Chemical Industries, Ltd. Preparations for vaginal administration
IT1229075B (it) * 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4605691A (en) * 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels

Also Published As

Publication number Publication date
AU600483B2 (en) 1990-08-16
WO1987005517A1 (en) 1987-09-24
EP0259485A1 (de) 1988-03-16
AU7206887A (en) 1987-10-09
EP0259485A4 (de) 1988-07-29

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Legal Events

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