CA1267145A - Octahydroindolo ¬2,3-a| quinolizin-1-yl- alkanecarboxylic acid amides and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same - Google Patents

Octahydroindolo ¬2,3-a| quinolizin-1-yl- alkanecarboxylic acid amides and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same

Info

Publication number
CA1267145A
CA1267145A CA000492294A CA492294A CA1267145A CA 1267145 A CA1267145 A CA 1267145A CA 000492294 A CA000492294 A CA 000492294A CA 492294 A CA492294 A CA 492294A CA 1267145 A CA1267145 A CA 1267145A
Authority
CA
Canada
Prior art keywords
group
general formula
octahydroindolo
alkyl group
quinolizin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000492294A
Other languages
English (en)
French (fr)
Inventor
Csaba Szantay
Ferenc Soti
Gyorgy Hajos
Elemer Ezer
Judit Matuz
Laszlo Szporny
Csaba Kuthi
Maria Incze
Zsuzsanna Nee Kardos Balogh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of CA1267145A publication Critical patent/CA1267145A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000492294A 1984-10-05 1985-10-04 Octahydroindolo ¬2,3-a| quinolizin-1-yl- alkanecarboxylic acid amides and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same Expired - Lifetime CA1267145A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU843776A HU191454B (en) 1984-10-05 1984-10-05 Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU3776/84 1984-10-05

Publications (1)

Publication Number Publication Date
CA1267145A true CA1267145A (en) 1990-03-27

Family

ID=10965440

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000492294A Expired - Lifetime CA1267145A (en) 1984-10-05 1985-10-04 Octahydroindolo ¬2,3-a| quinolizin-1-yl- alkanecarboxylic acid amides and their therapeutically useful acid addition salts, pharmaceutical compositions containing them and process for preparing same

Country Status (23)

Country Link
US (1) US4782052A (h)
EP (1) EP0177361A3 (h)
JP (1) JPS61126086A (h)
KR (1) KR860003254A (h)
CN (1) CN85109716A (h)
AU (1) AU578314B2 (h)
CA (1) CA1267145A (h)
DD (1) DD237659A5 (h)
DK (1) DK453485A (h)
ES (1) ES8701176A1 (h)
FI (1) FI853867A7 (h)
GR (1) GR852410B (h)
HU (1) HU191454B (h)
IL (1) IL76579A0 (h)
IN (1) IN162609B (h)
NO (1) NO161857B (h)
NZ (1) NZ213710A (h)
PH (1) PH23265A (h)
PL (1) PL145678B1 (h)
PT (1) PT81256B (h)
SU (1) SU1470193A3 (h)
YU (1) YU159085A (h)
ZA (1) ZA857687B (h)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582663B2 (en) * 1985-08-10 1989-04-06 John Wyeth & Brother Limited Sulphonamides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565804A (en) * 1975-10-28 1980-04-23 Inverni Della Beffa Spa Alkaloid derivatives
ZA786426B (en) * 1977-11-25 1979-10-31 Scras New indulo(2,3-a)quinolizidines,preparation and therapeutic use
HU178700B (en) * 1978-02-10 1982-06-28 Richter Gedeon Vegyeszet Process for preparing 1,1-disubstituted octahydro-indolo/2,3-a/-quinolizines
US4353911A (en) * 1979-07-20 1982-10-12 Andre Buzas Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
HU186891B (en) * 1981-06-12 1985-10-28 Richter Gedeon Vegyeszet Process for producing esters of apovincaminic acid
EP0079411B1 (fr) * 1981-11-18 1987-02-04 Thal, Claude Dérivés d'indoloquinolizine, leur procédé de préparation et leur application en thérapeutique
DE3204960A1 (de) * 1982-02-12 1983-08-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Corynanthein-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HU194221B (en) * 1985-04-19 1988-01-28 Richter Gedeon Vegyeszet Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU195214B (en) * 1985-04-19 1988-04-28 Richter Gedeon Vegyeszet Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds

Also Published As

Publication number Publication date
NO853936L (no) 1986-04-07
NZ213710A (en) 1988-08-30
FI853867A0 (fi) 1985-10-04
ES8701176A1 (es) 1986-11-16
PL255646A1 (en) 1986-10-21
PH23265A (en) 1989-06-23
PT81256A (en) 1985-11-01
NO161857B (no) 1989-06-26
PT81256B (pt) 1987-10-20
GR852410B (h) 1986-02-04
ES547605A0 (es) 1986-11-16
FI853867L (fi) 1986-04-06
KR860003254A (ko) 1986-05-21
DD237659A5 (de) 1986-07-23
IL76579A0 (en) 1986-02-28
CN85109716A (zh) 1986-10-08
AU4832985A (en) 1986-04-10
DK453485A (da) 1986-04-06
JPS61126086A (ja) 1986-06-13
IN162609B (h) 1988-06-18
SU1470193A3 (ru) 1989-03-30
FI853867A7 (fi) 1986-04-06
EP0177361A3 (en) 1987-09-02
DK453485D0 (da) 1985-10-04
US4782052A (en) 1988-11-01
AU578314B2 (en) 1988-10-20
ZA857687B (en) 1986-05-28
PL145678B1 (en) 1988-10-31
YU159085A (en) 1988-04-30
HU191454B (en) 1987-02-27
EP0177361A2 (en) 1986-04-09

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