CA1261261A - Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation - Google Patents
Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparationInfo
- Publication number
- CA1261261A CA1261261A CA000502076A CA502076A CA1261261A CA 1261261 A CA1261261 A CA 1261261A CA 000502076 A CA000502076 A CA 000502076A CA 502076 A CA502076 A CA 502076A CA 1261261 A CA1261261 A CA 1261261A
- Authority
- CA
- Canada
- Prior art keywords
- particulate
- calcium carbonate
- microcrystalline cellulose
- coprocessed
- slurry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 129
- 235000019813 microcrystalline cellulose Nutrition 0.000 title claims abstract description 84
- 239000008108 microcrystalline cellulose Substances 0.000 title claims abstract description 83
- 229940016286 microcrystalline cellulose Drugs 0.000 title claims abstract description 83
- 229920000168 Microcrystalline cellulose Polymers 0.000 title claims abstract description 65
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 239000002002 slurry Substances 0.000 claims abstract description 61
- 238000001035 drying Methods 0.000 claims abstract description 23
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000001694 spray drying Methods 0.000 claims abstract description 17
- 229940124531 pharmaceutical excipient Drugs 0.000 claims abstract description 9
- 235000010216 calcium carbonate Nutrition 0.000 claims description 58
- 229960003563 calcium carbonate Drugs 0.000 claims description 58
- 239000000047 product Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 28
- 239000002245 particle Substances 0.000 claims description 26
- 239000007787 solid Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000012736 aqueous medium Substances 0.000 claims description 7
- 239000011236 particulate material Substances 0.000 claims description 5
- 239000000306 component Substances 0.000 description 26
- 239000000314 lubricant Substances 0.000 description 9
- 235000010980 cellulose Nutrition 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 8
- 239000001913 cellulose Substances 0.000 description 8
- 238000007906 compression Methods 0.000 description 7
- 230000006835 compression Effects 0.000 description 7
- 238000007907 direct compression Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000004513 sizing Methods 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229940095672 calcium sulfate Drugs 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 150000002646 long chain fatty acid esters Chemical class 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70974885A | 1985-03-08 | 1985-03-08 | |
| US709,748 | 1985-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1261261A true CA1261261A (en) | 1989-09-26 |
Family
ID=24851174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000502076A Expired CA1261261A (en) | 1985-03-08 | 1986-02-18 | Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0193984B1 (OSRAM) |
| JP (1) | JPS61207343A (OSRAM) |
| AR (1) | AR242499A1 (OSRAM) |
| AU (1) | AU561604B2 (OSRAM) |
| CA (1) | CA1261261A (OSRAM) |
| DE (1) | DE3677028D1 (OSRAM) |
| ES (1) | ES8704977A1 (OSRAM) |
| MX (1) | MX168133B (OSRAM) |
| NO (1) | NO170056C (OSRAM) |
| ZA (1) | ZA861728B (OSRAM) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5725883A (en) * | 1995-01-09 | 1998-03-10 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US5733578A (en) * | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5741524A (en) * | 1995-01-09 | 1998-04-21 | Edward Mendell Co., Inc. | Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility |
| US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| US6391337B2 (en) | 1995-11-15 | 2002-05-21 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
| US6471994B1 (en) | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6852336B2 (en) | 1995-11-15 | 2005-02-08 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Directly compressible high load acetaminophen formulations |
| US6936277B2 (en) | 1995-01-09 | 2005-08-30 | J. Rettenmaier & Soehne Gmbh & Co. Kg | Pharmaceutical excipient having improved compressibility |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU206824B (en) * | 1990-08-24 | 1993-01-28 | Biogal Gyogyszergyar | Process for the production of a table crystallizing in the monoclinic system, which contains light-, heat-, and moisture- sensitive active agents |
| DE4318577A1 (de) * | 1993-06-04 | 1994-12-08 | Merck Patent Gmbh | Schmiermittelfreie, arzneimittelhaltige Tabletten |
| US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
| US5747067A (en) * | 1996-12-06 | 1998-05-05 | Fmc Corporation | Co-processed products |
| CA2275929C (en) * | 1996-12-24 | 2003-04-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Aqueous suspension composition and water-dispersible dry composition |
| JPH10237220A (ja) * | 1996-12-24 | 1998-09-08 | Asahi Chem Ind Co Ltd | 水性懸濁状組成物及び水分散性乾燥組成物 |
| US6037380A (en) * | 1997-04-11 | 2000-03-14 | Fmc Corporation | Ultra-fine microcrystalline cellulose compositions and process |
| NZ501383A (en) * | 1997-06-12 | 2001-02-23 | Fmc Corp | Ultra-fine microcrystalline cellulose compositions and process for their manufacture |
| CN1086189C (zh) * | 1997-06-12 | 2002-06-12 | 食品机械和化工公司 | 超细微晶纤维素组合物及其制备方法 |
| JP4484992B2 (ja) * | 1999-12-24 | 2010-06-16 | 丸尾カルシウム株式会社 | 食品添加剤スラリー組成物及びパウダー組成物、並びにこれらを含有する食品組成物 |
| JP2005232260A (ja) * | 2004-02-18 | 2005-09-02 | Asahi Kasei Chemicals Corp | セルロース無機化合物多孔質複合粒子 |
| US7998505B2 (en) * | 2006-10-27 | 2011-08-16 | Fmc Corporation | Dry granulation binders, products, and use thereof |
| TWI461213B (zh) * | 2009-11-05 | 2014-11-21 | Fmc Corp | 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物 |
| EP2515943A4 (en) * | 2009-12-22 | 2014-04-30 | Fmc Corp | MICROCRYSTALLINE CELLULOSE AND CALCIUM CARBONATE COMPOSITIONS USEFUL AS RECOMPACTABLE PHARMACEUTICAL EXCIPIENTS |
| KR101727174B1 (ko) * | 2015-06-16 | 2017-04-14 | (주)다이나텍 | 토크 측정을 위한 등속 조인트 및 등속 조인트를 위한 무선 토크 측정 장치 |
| KR102659626B1 (ko) * | 2023-05-19 | 2024-04-23 | 코스맥스 주식회사 | 분무건조 공정을 이용한 구형 탄산칼슘-셀룰로오스 복합입자의 제조방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0047734A1 (en) * | 1980-03-10 | 1982-03-24 | Edward Mendell Co., Inc. | Pharmaceutical vehicle composition and process of producing same |
-
1986
- 1986-02-18 CA CA000502076A patent/CA1261261A/en not_active Expired
- 1986-02-19 DE DE8686200256T patent/DE3677028D1/de not_active Expired - Lifetime
- 1986-02-19 EP EP86200256A patent/EP0193984B1/en not_active Expired - Lifetime
- 1986-03-07 JP JP61050250A patent/JPS61207343A/ja active Granted
- 1986-03-07 MX MX001787A patent/MX168133B/es unknown
- 1986-03-07 AU AU54422/86A patent/AU561604B2/en not_active Ceased
- 1986-03-07 AR AR86303317A patent/AR242499A1/es active
- 1986-03-07 NO NO860867A patent/NO170056C/no unknown
- 1986-03-07 ES ES552800A patent/ES8704977A1/es not_active Expired
- 1986-03-07 ZA ZA861728A patent/ZA861728B/xx unknown
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6471994B1 (en) | 1995-01-09 | 2002-10-29 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6746693B2 (en) | 1995-01-09 | 2004-06-08 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Pharmaceutical excipient having improved compressibility |
| US5741524A (en) * | 1995-01-09 | 1998-04-21 | Edward Mendell Co., Inc. | Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility |
| US5858412A (en) * | 1995-01-09 | 1999-01-12 | Edward Mendell Co., Inc. | Sustained release formulations utilizing pharmaceutical excipient having improved compressibility with modified microcrystalline |
| US5866166A (en) * | 1995-01-09 | 1999-02-02 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US5948438A (en) * | 1995-01-09 | 1999-09-07 | Edward Mendell Co., Inc. | Pharmaceutical formulations having improved disintegration and/or absorptivity |
| US6936277B2 (en) | 1995-01-09 | 2005-08-30 | J. Rettenmaier & Soehne Gmbh & Co. Kg | Pharmaceutical excipient having improved compressibility |
| US6217909B1 (en) | 1995-01-09 | 2001-04-17 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6858231B2 (en) | 1995-01-09 | 2005-02-22 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Pharmaceutical excipient having improved compressibility |
| US5725883A (en) * | 1995-01-09 | 1998-03-10 | Edward Mendell Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6358533B2 (en) | 1995-01-09 | 2002-03-19 | Edward Mendell, Co., Inc. | Pharmaceutical excipient having improved compressibility |
| US6391337B2 (en) | 1995-11-15 | 2002-05-21 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US6217907B1 (en) | 1995-11-15 | 2001-04-17 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US6852336B2 (en) | 1995-11-15 | 2005-02-08 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Directly compressible high load acetaminophen formulations |
| US5733578A (en) * | 1995-11-15 | 1998-03-31 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US5965166A (en) * | 1995-11-15 | 1999-10-12 | Edward Mendell Co., Inc. | Directly compressible high load acetaminophen formulations |
| US6395303B1 (en) | 1996-06-10 | 2002-05-28 | Edward Mendell Co., Inc. | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
| US6866867B2 (en) | 1996-06-10 | 2005-03-15 | J. Rettenmaier & Soehne Gmbh + Co. Kg | Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5442286A (en) | 1986-09-11 |
| NO170056B (no) | 1992-06-01 |
| JPH0440331B2 (OSRAM) | 1992-07-02 |
| JPS61207343A (ja) | 1986-09-13 |
| ES8704977A1 (es) | 1987-04-16 |
| AR242499A1 (es) | 1993-04-30 |
| MX168133B (es) | 1993-05-06 |
| NO170056C (no) | 1992-09-09 |
| ZA861728B (en) | 1986-10-29 |
| NO860867L (no) | 1986-09-09 |
| AU561604B2 (en) | 1987-05-14 |
| EP0193984A3 (en) | 1987-08-19 |
| DE3677028D1 (de) | 1991-02-28 |
| EP0193984B1 (en) | 1991-01-23 |
| ES552800A0 (es) | 1987-04-16 |
| EP0193984A2 (en) | 1986-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20060926 |