CA1252461A - Bicyclooctane derivatives and their production and use - Google Patents

Bicyclooctane derivatives and their production and use

Info

Publication number
CA1252461A
CA1252461A CA000446010A CA446010A CA1252461A CA 1252461 A CA1252461 A CA 1252461A CA 000446010 A CA000446010 A CA 000446010A CA 446010 A CA446010 A CA 446010A CA 1252461 A CA1252461 A CA 1252461A
Authority
CA
Canada
Prior art keywords
group
hydroxy
bicyclo
cis
octane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000446010A
Other languages
English (en)
French (fr)
Inventor
Masami Muraoka
Toshio Nakamura
Akihiko Sugie
Keiichi Ono
Michihiro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of CA1252461A publication Critical patent/CA1252461A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
CA000446010A 1983-02-01 1984-01-25 Bicyclooctane derivatives and their production and use Expired CA1252461A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58015837A JPS59141536A (ja) 1983-02-01 1983-02-01 新規ビシクロオクタン誘導体
JP15837/83 1983-02-01

Publications (1)

Publication Number Publication Date
CA1252461A true CA1252461A (en) 1989-04-11

Family

ID=11899945

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000446010A Expired CA1252461A (en) 1983-02-01 1984-01-25 Bicyclooctane derivatives and their production and use

Country Status (9)

Country Link
US (1) US4680307A (en, 2012)
EP (1) EP0115954B1 (en, 2012)
JP (1) JPS59141536A (en, 2012)
AT (1) ATE29024T1 (en, 2012)
AU (1) AU567911B2 (en, 2012)
CA (1) CA1252461A (en, 2012)
DE (1) DE3465470D1 (en, 2012)
DK (1) DK171295B1 (en, 2012)
ES (1) ES8600196A1 (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3428266A1 (de) * 1984-07-27 1986-01-30 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5523321A (en) * 1985-07-19 1996-06-04 Schering Aktiengeselleschaft Prostacyclins, their analogs or prostaglandins and thromboxane antagonists for treatment of thrombotic and thromboembolic syndromes
JPS62153259A (ja) * 1985-12-26 1987-07-08 Sagami Chem Res Center （２−クロロ−３−オキソ−１−アルケニル）−ビシクロ〔３．３．０〕オクテン誘導体及びその製法
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives
JPH01110644A (ja) * 1986-12-04 1989-04-27 Sagami Chem Res Center ホモイソカルバサイクリン類縁体並びにそれを有効成分とする循環改善剤及び抗潰瘍剤
ATE306256T1 (de) 1999-08-05 2005-10-15 Teijin Ltd Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
CA2780683A1 (en) 2009-11-13 2011-05-19 Toray Industries, Inc. Therapeutic or prophylactic combination of a prostaglandin i2 and a thiazolidine for diabetes

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923861A (en) * 1969-07-29 1975-12-02 Upjohn Co 3-Oxa prostaglandin F{331 -type compounds
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation
DE2912409A1 (de) * 1978-03-31 1979-10-11 Ono Pharmaceutical Co 6,9-methano-pgi tief 2 -analoge
DE3168001D1 (en) * 1980-03-21 1985-02-14 Sumitomo Chemical Co Bicyclooctane derivatives, processes for producing them, pharmaceutical compositions containing them, their use as pharmaceuticals and precursors thereof
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58110539A (ja) * 1981-12-25 1983-07-01 Sankyo Co Ltd カルバプロスタサイクリン類
GR77976B (en, 2012) * 1982-03-12 1984-09-25 Schering Ag
DE3225288A1 (de) * 1982-07-02 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3226550A1 (de) * 1982-07-13 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS5913747A (ja) * 1982-07-14 1984-01-24 Ota Seiyaku Kk シス−ビシクロ〔３，３，０〕オクタン化合物及びその製造法
JPS5916852A (ja) * 1982-07-19 1984-01-28 Ota Seiyaku Kk シス−ビシクロ〔３，３，０〕オクタン化合物

Also Published As

Publication number Publication date
AU567911B2 (en) 1987-12-10
DK43384D0 (da) 1984-01-31
DK43384A (da) 1984-08-02
EP0115954A2 (en) 1984-08-15
DE3465470D1 (en) 1987-09-24
EP0115954A3 (en) 1984-11-07
DK171295B1 (da) 1996-08-26
EP0115954B1 (en) 1987-08-19
ES529281A0 (es) 1985-10-01
JPS59141536A (ja) 1984-08-14
ATE29024T1 (de) 1987-09-15
AU2372684A (en) 1984-08-02
US4680307A (en) 1987-07-14
JPH0414091B2 (en, 2012) 1992-03-11
ES8600196A1 (es) 1985-10-01

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Legal Events

Date Code Title Description
MKEX Expiry