CA1246054A - Synthetic st toxin, process for its preparation and its use as a vaccinating agent - Google Patents

Synthetic st toxin, process for its preparation and its use as a vaccinating agent

Info

Publication number
CA1246054A
CA1246054A CA000426666A CA426666A CA1246054A CA 1246054 A CA1246054 A CA 1246054A CA 000426666 A CA000426666 A CA 000426666A CA 426666 A CA426666 A CA 426666A CA 1246054 A CA1246054 A CA 1246054A
Authority
CA
Canada
Prior art keywords
cys
asn
tyr
gly
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000426666A
Other languages
English (en)
French (fr)
Inventor
Anabela Duflot
Patrice Boquet
Edith Duflot
Helene Gras
Andre Tartar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Application granted granted Critical
Publication of CA1246054A publication Critical patent/CA1246054A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/832—Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA000426666A 1982-04-26 1983-04-25 Synthetic st toxin, process for its preparation and its use as a vaccinating agent Expired CA1246054A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8207179A FR2525592B1 (https=) 1982-04-26 1982-04-26
FR8207179 1982-04-26

Publications (1)

Publication Number Publication Date
CA1246054A true CA1246054A (en) 1988-12-06

Family

ID=9273400

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000426666A Expired CA1246054A (en) 1982-04-26 1983-04-25 Synthetic st toxin, process for its preparation and its use as a vaccinating agent

Country Status (6)

Country Link
US (1) US4499080A (https=)
EP (1) EP0093652B1 (https=)
JP (1) JPS58201754A (https=)
CA (1) CA1246054A (https=)
DE (1) DE3368387D1 (https=)
FR (1) FR2525592B1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526716A (en) * 1981-11-20 1985-07-02 The Ohio State University Antigenic modification of polypeptides
US5698201A (en) * 1973-05-07 1997-12-16 The Ohio State University Method for treatment of antigenically modified polypeptides
US4767842A (en) * 1973-05-07 1988-08-30 The Ohio State University Antigenic modification of polypeptides
US4762913A (en) * 1973-05-07 1988-08-09 The Ohio State University Antigenic modification of polypeptides
US6143305A (en) * 1973-05-07 2000-11-07 The Ohio State University Antigenically modified polypeptides composition
US6039948A (en) * 1973-05-07 2000-03-21 The Ohio State University Method for treatment of antigenically modified polypeptides
US5006334A (en) * 1973-05-07 1991-04-09 The Ohio State University Antigenic modification of polypeptides
US6096318A (en) * 1973-05-07 2000-08-01 The Ohio State University Antigenically modified HCG polypeptides
US4886663A (en) * 1983-01-03 1989-12-12 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof
US4575495A (en) * 1983-05-12 1986-03-11 New York Blood Center, Inc. Synthetic antigenic peptide derived from Hepatitis B surface antigen
US4578217A (en) * 1983-05-12 1986-03-25 New York Blood Center, Inc. Synthetic antigenic peptide derived from hepatitis B surface antigen
IL69558A (en) * 1983-08-23 1988-06-30 Yeda Res & Dev Synthetic cholera vaccine
FR2551088B1 (https=) * 1983-08-29 1985-12-06 Pasteur Institut
US4740585A (en) * 1984-07-30 1988-04-26 The Board Of Trustees Of The Leland Stanford Junior University Synthetic vaccine against urinary infections
US4855285A (en) * 1985-12-04 1989-08-08 The Ohio State University Research Foundation Antigenic modification of polypeptides
US5817753A (en) 1985-12-04 1998-10-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
US4929718A (en) * 1987-12-14 1990-05-29 Universidad Nacional Autonoma De Mexico Synthetic noxiustoxin related peptides
US5439792A (en) * 1989-06-02 1995-08-08 Genetic Systems Corporation Cysteine thiol-protected peptides for use in immunoassays
CA2056381C (en) * 1989-06-02 2000-08-22 James Blake Cysteine thiol-protected peptides for use in immunoassays
EP0438332B1 (fr) * 1990-01-16 1998-04-08 Orgenics Ltd. Peptides dérivant de la glycoprotéine d'enveloppe de virus HIV, leurs applications à la détection d'une infection due à ces virus et à la vaccination contre le SIDA
HU206372B (en) * 1990-09-03 1992-10-28 Richter Gedeon Vegyeszet Process for producing new oligopeptides which selectively inhibit proliferation of haemopoietic cells and pharmaceutical compositions comprising same
TW227004B (https=) * 1990-12-19 1994-07-21 Hoechst Ag
JP2955082B2 (ja) * 1991-10-11 1999-10-04 大阪瓦斯株式会社 ヒトカルシトニンのｎ末端部分を特異的に認識するモノクローナル抗体
US7097839B1 (en) * 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
AUPO427596A0 (en) * 1996-12-20 1997-01-23 Cooperative Research Centre For Tropical Plant Pathology Anti-microbial protein
JP4037933B2 (ja) * 1996-12-24 2008-01-23 大阪瓦斯株式会社 抗ヒトカルシトニンモノクローナル抗体
US6008378A (en) * 1997-10-21 1999-12-28 The Regents Of The University Of California Synthetic molecules that specifically react with target sequences
CA2321961A1 (en) 1998-02-24 1999-08-26 Dovetail Technologies Inc. Novel disulfides and thiol compounds
EP2355846A4 (en) 2008-09-03 2013-06-19 Univ Michigan State IMMUNOGENIC HEAT STABILIZER ESCHERICHIA COLI-ENTEROTOXIN

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5836308B2 (ja) * 1977-02-10 1983-08-08 大塚製薬株式会社 抗体の製造方法
CA1138773A (en) * 1979-04-18 1983-01-04 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4314993A (en) * 1980-04-04 1982-02-09 Smithkline-Rit Immunogenic E. coli ST enterotoxin derivatives and compositions containing them
US4290944A (en) * 1980-07-31 1981-09-22 Northwestern University Antigenic peptide compound

Also Published As

Publication number Publication date
FR2525592A1 (https=) 1983-10-28
EP0093652B1 (fr) 1986-12-17
DE3368387D1 (en) 1987-01-29
EP0093652A1 (fr) 1983-11-09
FR2525592B1 (https=) 1984-09-14
JPS58201754A (ja) 1983-11-24
US4499080A (en) 1985-02-12

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