CA1241641A - Osteogenic factors - Google Patents

Osteogenic factors

Info

Publication number
CA1241641A
CA1241641A CA000471370A CA471370A CA1241641A CA 1241641 A CA1241641 A CA 1241641A CA 000471370 A CA000471370 A CA 000471370A CA 471370 A CA471370 A CA 471370A CA 1241641 A CA1241641 A CA 1241641A
Authority
CA
Canada
Prior art keywords
protein
bone
proteins
osteogenic
calf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000471370A
Other languages
English (en)
French (fr)
Inventor
Arup Sen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Genetic Engineering Inc
Original Assignee
International Genetic Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Genetic Engineering Inc filed Critical International Genetic Engineering Inc
Application granted granted Critical
Publication of CA1241641A publication Critical patent/CA1241641A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA000471370A 1984-01-04 1985-01-03 Osteogenic factors Expired CA1241641A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56816784A 1984-01-04 1984-01-04
US568,167 1984-01-04

Publications (1)

Publication Number Publication Date
CA1241641A true CA1241641A (en) 1988-09-06

Family

ID=24270176

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000471370A Expired CA1241641A (en) 1984-01-04 1985-01-03 Osteogenic factors

Country Status (11)

Country Link
EP (1) EP0148155B1 (cs)
JP (1) JPS60226814A (cs)
AT (1) ATE42309T1 (cs)
AU (1) AU580975B2 (cs)
CA (1) CA1241641A (cs)
DE (1) DE3569542D1 (cs)
DK (1) DK161524C (cs)
GR (1) GR850006B (cs)
IE (1) IE57966B1 (cs)
NZ (1) NZ210699A (cs)
ZA (1) ZA8547B (cs)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
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US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
JPH0723322B2 (ja) * 1985-12-07 1995-03-15 克之 藤井 液状骨形成剤からなる注射液
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
DE3626414C2 (de) * 1986-08-05 1994-11-10 Robapharm Ag Präparat zur Stimulierung von Chondrocyten und Osteoblasten (Ossein-Hydroxyapatit-Komplex), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
US5154931A (en) * 1986-10-22 1992-10-13 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) Growth-stimulating material derived from porcine bone therefor and a manufacturing process
JPH04505607A (ja) * 1988-04-06 1992-10-01 セルトリックス　ファーマシューティカルズ　インコーポレイテッド 骨誘導タンパク
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
DE68929453T2 (de) * 1988-04-08 2003-11-20 Stryker Corp., Kalamazoo Osteogene Vorrichtungen
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
IL90683A0 (en) * 1988-06-27 1990-01-18 Yissum Res Dev Co Osteogenic growth factors derived from regenerating bone marrow
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
US5645591A (en) * 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
WO1994026892A1 (en) 1993-05-12 1994-11-24 Genetics Institute, Inc. Bmp-11 compositions
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ATE319823T1 (de) 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
AU774427B2 (en) 1999-10-15 2004-06-24 Fidia Advanced Biopolymers S.R.L. Formulations of hyaluronic acid for delivery of osteogenic proteins
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
AU2003240196A1 (en) 2002-06-20 2004-01-23 Nicolaas Duneas Osteoinductive biomaterials
PT1675608E (pt) 2003-09-12 2007-05-31 Etex Corp Barras sólidas e pastas de fosfato de cálcio injectável para a libertação de proteínas osteogénicas.
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
PT1771470E (pt) 2004-07-23 2013-08-27 Acceleron Pharma Inc Polipéptidos do receptor actrii, métodos e composições
EP1942960B1 (en) 2005-11-01 2012-08-29 Warsaw Orthopedic, Inc. Methods for producing bone matrix composition
TW202104248A (zh) 2007-02-02 2021-02-01 美商艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US8357384B2 (en) 2007-06-15 2013-01-22 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US8202539B2 (en) 2007-10-19 2012-06-19 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
AU2010322011B2 (en) 2009-11-17 2016-03-31 Acceleron Pharma Inc. ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
JP7280182B2 (ja) 2016-10-05 2023-05-23 アクセルロン ファーマ インコーポレイテッド バリアントＡｃｔＲＩＩＢタンパク質およびその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process

Also Published As

Publication number Publication date
DE3569542D1 (en) 1989-05-24
EP0148155A3 (en) 1986-08-13
JPS60226814A (ja) 1985-11-12
DK2285D0 (da) 1985-01-02
DK2285A (da) 1985-07-05
EP0148155A2 (en) 1985-07-10
GR850006B (cs) 1985-05-03
NZ210699A (en) 1989-06-28
DK161524C (da) 1991-12-23
AU3722184A (en) 1985-07-11
ZA8547B (en) 1986-09-24
DK161524B (da) 1991-07-15
EP0148155B1 (en) 1989-04-19
ATE42309T1 (de) 1989-05-15
IE850010L (en) 1985-07-04
AU580975B2 (en) 1989-02-09
IE57966B1 (en) 1993-06-02

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