CA1239585A - Medicament microencapsule dans une matrice sucree - Google Patents
Medicament microencapsule dans une matrice sucreeInfo
- Publication number
- CA1239585A CA1239585A CA000464346A CA464346A CA1239585A CA 1239585 A CA1239585 A CA 1239585A CA 000464346 A CA000464346 A CA 000464346A CA 464346 A CA464346 A CA 464346A CA 1239585 A CA1239585 A CA 1239585A
- Authority
- CA
- Canada
- Prior art keywords
- matrix
- active principle
- chocolate
- dosage form
- accordance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 239000003814 drug Substances 0.000 title abstract description 60
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- 239000003094 microcapsule Substances 0.000 claims abstract description 57
- 239000002552 dosage form Substances 0.000 claims abstract 14
- 244000299461 Theobroma cacao Species 0.000 claims description 58
- 238000000034 method Methods 0.000 claims description 14
- 238000005538 encapsulation Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 2
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- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 description 1
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- 229940125722 laxative agent Drugs 0.000 description 1
- 229960005287 lincomycin Drugs 0.000 description 1
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000001035 marshmallow Nutrition 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960000564 nitrofurantoin Drugs 0.000 description 1
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 1
- 229960002950 novobiocin Drugs 0.000 description 1
- YJQPYGGHQPGBLI-KGSXXDOSSA-N novobiocin Chemical compound O1C(C)(C)[C@H](OC)[C@@H](OC(N)=O)[C@@H](O)[C@@H]1OC1=CC=C(C(O)=C(NC(=O)C=2C=C(CC=C(C)C)C(O)=CC=2)C(=O)O2)C2=C1C YJQPYGGHQPGBLI-KGSXXDOSSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 235000019371 penicillin G benzathine Nutrition 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 229940056367 penicillin v Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229960001190 pheniramine Drugs 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 229960002305 phenylpropanolamine hydrochloride Drugs 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- DGMKFQYCZXERLX-UHFFFAOYSA-N proglumide Chemical compound CCCN(CCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC=CC=C1 DGMKFQYCZXERLX-UHFFFAOYSA-N 0.000 description 1
- 229960003857 proglumide Drugs 0.000 description 1
- HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
- 229960003672 propicillin Drugs 0.000 description 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 description 1
- 230000000506 psychotropic effect Effects 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 238000007391 self-medication Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 229960001294 spiramycin Drugs 0.000 description 1
- 235000019372 spiramycin Nutrition 0.000 description 1
- 229930191512 spiramycin Natural products 0.000 description 1
- 229940041022 streptomycins Drugs 0.000 description 1
- 229940089453 sudafed Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- ASWVTGNCAZCNNR-UHFFFAOYSA-N sulfamethazine Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ASWVTGNCAZCNNR-UHFFFAOYSA-N 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- QWCJHSGMANYXCW-UHFFFAOYSA-N sulfaphenazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CC=NN1C1=CC=CC=C1 QWCJHSGMANYXCW-UHFFFAOYSA-N 0.000 description 1
- 229960004818 sulfaphenazole Drugs 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/42—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G1/426—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53880183A | 1983-10-03 | 1983-10-03 | |
| US538,801 | 1990-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1239585A true CA1239585A (fr) | 1988-07-26 |
Family
ID=24148464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000464346A Expired CA1239585A (fr) | 1983-10-03 | 1984-09-28 | Medicament microencapsule dans une matrice sucree |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS60105612A (fr) |
| AU (1) | AU3379984A (fr) |
| BE (1) | BE900749A (fr) |
| CA (1) | CA1239585A (fr) |
| CH (1) | CH661663A5 (fr) |
| DE (1) | DE3435747A1 (fr) |
| DK (1) | DK472584A (fr) |
| FR (1) | FR2552665B1 (fr) |
| GB (1) | GB2147501B (fr) |
| IL (1) | IL73157A (fr) |
| IT (1) | IT1178019B (fr) |
| NL (1) | NL8403003A (fr) |
| SE (1) | SE8404808L (fr) |
| ZA (1) | ZA847743B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4749575A (en) * | 1983-10-03 | 1988-06-07 | Bio-Dar Ltd. | Microencapsulated medicament in sweet matrix |
| US4937076A (en) * | 1984-08-10 | 1990-06-26 | Combe Incorporated | Chewable aspirin and buffering material tablet and method for producing same |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| SE8605515D0 (sv) * | 1986-12-22 | 1986-12-22 | Astra Laekemedel Ab | A liquid dosage form for oral administration of a pharmaceutically active substance |
| US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
| GR1001437B (el) * | 1992-11-05 | 1993-12-30 | Aggelos Kontos | Ζαχαροπλαστικό σύστημα χορηγήσεως φαρμακολογικώς δραστικών ουσιών. |
| US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
| AU5135898A (en) * | 1996-12-03 | 1998-06-29 | Schering-Plough Kabushiki Kaisha | Controlled release matrix tablet and method for its preparation |
| US6328994B1 (en) * | 1998-05-18 | 2001-12-11 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
| TWI257311B (en) | 1998-07-28 | 2006-07-01 | Takeda Chemical Industries Ltd | Rapidly disintegrable solid preparation |
| GB2356346A (en) * | 1999-11-19 | 2001-05-23 | Mars Uk Ltd | Food product for oral delivery of a pharmaceutical agent to a non-human animal comprising encapsulated particles of said agent distributed within the product |
| US6541025B1 (en) * | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
| SE0103210D0 (sv) * | 2001-09-27 | 2001-09-27 | Pharmacia Ab | New formulations and use thereof |
| US7371405B2 (en) * | 2003-12-22 | 2008-05-13 | Mcneil-Ppc, Inc. | Consumer customized dosage forms |
| EP2542096B1 (fr) * | 2010-03-05 | 2015-07-15 | Ophthalmopharma AG | Complement alimentaire sous forme de chocolat ou produit derive |
| UA120715C2 (uk) | 2015-03-31 | 2020-01-27 | Лабораторіос Баго С.А. | Пелети, вкриті ентеросолюбільною оболонкою, які містять інгібітор протонної помпи |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB490001A (en) * | 1936-12-03 | 1938-08-02 | Atlantic Coast Fisheries Co | Improvements in or relating to a vitamin product |
| GB543309A (en) * | 1940-12-04 | 1942-02-19 | John David Evans | Improvements in or relating to drugs |
| US3265629A (en) * | 1958-12-22 | 1966-08-09 | Ncr Co | Coating by phase separation |
| US3697641A (en) * | 1970-01-02 | 1972-10-10 | Gerhard W Ahrens | Nonhygroscopic non-sugarbase noncariogenic-vitamin c releasable base material for use in the preparation of suckable tablets,lozenges and chocolate |
| CH519858A (fr) * | 1971-05-04 | 1972-03-15 | Interfood S A | Procédé de préparation de denrées alimentaires thermo-résistantes à base de matières grasses |
| GB1403584A (en) * | 1972-05-19 | 1975-08-28 | Beecham Group Ltd | Control medicaments |
| BE791458A (fr) * | 1972-07-31 | 1973-05-16 | Merck & Co Inc | Produit microencapsule |
| DE2347713C3 (de) * | 1972-09-25 | 1980-03-06 | Warner-Lambert Co., Morris Plains, N.J. (V.St.A.) | Acetylsalicylsäurekautablette |
| US4288460A (en) * | 1979-05-24 | 1981-09-08 | Balchem Corporation | Non-caking, water-soluble, granular coated food ingredient |
| US4271142A (en) * | 1979-06-18 | 1981-06-02 | Life Savers, Inc. | Portable liquid antacids |
| GB2075818B (en) * | 1980-05-21 | 1984-09-05 | Farm Feed Holdings Ltd | Torrefied cereals for use in the feeding and veterinary treatment of ruminant animals |
| US4327077A (en) * | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
| EP0083372B1 (fr) * | 1981-07-15 | 1988-05-18 | Key Pharmaceuticals, Inc. | Theophylline a liberation prolongee |
-
1984
- 1984-09-26 SE SE8404808A patent/SE8404808L/ unknown
- 1984-09-28 DE DE19843435747 patent/DE3435747A1/de not_active Ceased
- 1984-09-28 CA CA000464346A patent/CA1239585A/fr not_active Expired
- 1984-10-02 CH CH4740/84A patent/CH661663A5/de not_active IP Right Cessation
- 1984-10-02 DK DK472584A patent/DK472584A/da not_active Application Discontinuation
- 1984-10-02 ZA ZA847743A patent/ZA847743B/xx unknown
- 1984-10-02 GB GB08424833A patent/GB2147501B/en not_active Expired
- 1984-10-02 NL NL8403003A patent/NL8403003A/nl active Search and Examination
- 1984-10-02 JP JP59205710A patent/JPS60105612A/ja active Pending
- 1984-10-02 FR FR8415090A patent/FR2552665B1/fr not_active Expired
- 1984-10-03 AU AU33799/84A patent/AU3379984A/en not_active Abandoned
- 1984-10-03 IL IL73157A patent/IL73157A/xx not_active IP Right Cessation
- 1984-10-03 IT IT48945/84A patent/IT1178019B/it active
- 1984-10-03 BE BE0/213776A patent/BE900749A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2552665B1 (fr) | 1988-09-09 |
| NL8403003A (nl) | 1985-05-01 |
| IT8448945A0 (it) | 1984-10-03 |
| GB8424833D0 (en) | 1984-11-07 |
| ZA847743B (en) | 1985-06-26 |
| DK472584D0 (da) | 1984-10-02 |
| DE3435747A1 (de) | 1985-04-11 |
| CH661663A5 (de) | 1987-08-14 |
| GB2147501A (en) | 1985-05-15 |
| SE8404808L (sv) | 1985-04-04 |
| BE900749A (fr) | 1985-02-01 |
| SE8404808D0 (sv) | 1984-09-26 |
| JPS60105612A (ja) | 1985-06-11 |
| IT8448945A1 (it) | 1986-04-03 |
| DK472584A (da) | 1985-04-04 |
| FR2552665A1 (fr) | 1985-04-05 |
| AU3379984A (en) | 1985-04-18 |
| IL73157A (en) | 1988-10-31 |
| GB2147501B (en) | 1988-01-27 |
| IL73157A0 (en) | 1985-01-31 |
| IT1178019B (it) | 1987-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20050726 |